British Society for Immunology’s Post

With articles delving into diverse topics under the new ‘Treatment of…’ series, Clinical & Experimental Immunology provides a comprehensive overview of immunopathology, treatment options, and future developments in immune-mediated diseases. Read the articles and learn how to submit your work: https://oxford.ly/4bVDeC8

Our latest study, "Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19", is now published in Frontiers in Immunology! This work provides critical insights into the immune and metabolic alterations in kidney transplant recipients with COVID-19, highlighting pathways like glycolysis, glucose metabolism, and neutrophil degranulation, especially in patients with acute kidney injury (AKI).

Schematic structure of the T-cell receptor (TCR)👇 📎The schematic structure of the T-cell receptor (TCR) typically consists of an α chain and a β chain. Each chain comprises two immunoglobulin (Ig) domains and includes a C-terminal transmembrane domain at the bottom. 📎The N-terminal Ig domains of both chains (Vα and Vβ) are highly variable, particularly the three hypervariable regions known as complementary determining regions (CDRs), which form the binding site for peptide-MHC complexes. #tcellreceptor #immunology #cancerbiologyresearch Credit: Carsten Carlberg, Eunike Velleuer - Molecular Immunology_ How Science Works-Springer (2022)

Inflammatory changes can be found in the bone marrow of a whole range of hematological malignancies 🔥 But why are the downstream effects so different? Tom Cupedo and I explore this question in our new review out in Nature Reviews Immunology, with brilliant help of Lanpeng Chen and Marc Raaijmakers sharing their expertise in MDS/AML We hope you enjoy! https://rdcu.be/dBkF2

Check out our latest episode! Dr. Gail Bishop from the University of Iowa talks about her research on TRAF signaling and her work as Editor-in-Chief of The Journal of Immunology! 📚 Listen now: https://bit.ly/3ZGdo0a

A/Prof Joshua Ooi will be giving a seminar on 16 September, where he will share on his development of genetically-engineered antigen-specific Treg to suppress pathogenic autoreactivity in lupus. The NUSMED ITRP Seminar Series aims to highlight the latest research in immunology and immunity in Asia and around the world. #lupus #Tregs #autoimmunity

📄 Our poster titled, "Efficacy Evaluation of B Cell-Targeting Drug Candidates Using Humanized BAFF Transgenic SLE Mouse Model" from the American Association of Immunologists annual meeting, Immunology 24, is also now available for download! ▶️ Head on over to our event page now to view: https://buff.ly/3LM0WoZ 👩🔬 Read the intro: GemPharmatech developed a transgenic mouse model, B6-hBAFF, with human B-cell-activating factor (BAFF) overexpression to study Systemic Lupus Erythematosus (SLE). Elevated BAFF levels in these mice increased immunoglobulin (Ig) and anti-dsDNA levels from early ages, accompanied by an expanded B cell population and reduced T cell ratio. #BAFF #SLE #lupus #preclinicalresearch #AAI24

Dr. Owen Witte, presidential chair in developmental immunology at UCLA Health, details how the California Institute for Immunology and Immunotherapy (CIII) is slated to become an epicenter for innovation. Through streamlined collaboration, research at this site will usher a new future for patient treatment options.

Talk to me about the use of #transcriptomics in immunology? I’d like to learn more. In this post-hoc analysis from the TN10 trial in #TrialNet, a randomized placebo-controlled trial using #Teplizumab vs. placebo in stage 2 #T1D, the investigators Ana Lledo Delgado Kevan Herold and colleagues aimed to understand the underlying mechanisms of persistence of response in responders to teplizumab. They describe what they call an ‘operational tolerance’ in responders with a pattern of initial increase in transcriptomic signatures of CD8+ T cell activation followed by a decline at 18 months with features of immune regulation and exhaustion. The numbers are small, though the authors validated and confirmed findings in a second sub-cohort as well as compared to data from healthy controls from published data. Now go read it! https://lnkd.in/efKXu6YH

🔍 ASHI Insights: Dive into the complexities of DPB epitopes and their interpretation within G/P groups. Discover how these subtle variations can have a significant impact on immunogenetics. Stay informed and explore the latest research in human immunology.