NUSMED Immunology TRP’s Post

For World Primary Immunodeficiency Week #WorldPIWeek, recap the latest developments in #InbornErrors research in this great Review Series published in our official journal Clinical & Experimental Immunology: https://bit.ly/442dnoL Understanding more about #PrimaryImmunodeficiency will not only help us diagnose & treat these conditions but also further our understanding of the immune system.

📄 Our poster titled, "Efficacy Evaluation of B Cell-Targeting Drug Candidates Using Humanized BAFF Transgenic SLE Mouse Model" from the American Association of Immunologists annual meeting, Immunology 24, is also now available for download! ▶️ Head on over to our event page now to view: https://buff.ly/3LM0WoZ 👩🔬 Read the intro: GemPharmatech developed a transgenic mouse model, B6-hBAFF, with human B-cell-activating factor (BAFF) overexpression to study Systemic Lupus Erythematosus (SLE). Elevated BAFF levels in these mice increased immunoglobulin (Ig) and anti-dsDNA levels from early ages, accompanied by an expanded B cell population and reduced T cell ratio. #BAFF #SLE #lupus #preclinicalresearch #AAI24

Schematic structure of the T-cell receptor (TCR)👇 📎The schematic structure of the T-cell receptor (TCR) typically consists of an α chain and a β chain. Each chain comprises two immunoglobulin (Ig) domains and includes a C-terminal transmembrane domain at the bottom. 📎The N-terminal Ig domains of both chains (Vα and Vβ) are highly variable, particularly the three hypervariable regions known as complementary determining regions (CDRs), which form the binding site for peptide-MHC complexes. #tcellreceptor #immunology #cancerbiologyresearch Credit: Carsten Carlberg, Eunike Velleuer - Molecular Immunology_ How Science Works-Springer (2022)

Check out our latest episode! Dr. Gail Bishop from the University of Iowa talks about her research on TRAF signaling and her work as Editor-in-Chief of The Journal of Immunology! 📚 Listen now: https://bit.ly/3ZGdo0a

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We are breaking new ground in immunology and inflammation, targeting the previously undruggable VAV1 protein, a key regulator of T- and B-cell receptor activity. Sharon Townson, Chief Scientific Officer, and Marisa P., Director of Target and Discovery Biology, discuss MRT-6160 - Monte Rosa’s potent, highly selective, and orally bioavailable, investigational VAV1-targeted molecular glue degrader - and its potential in diseases like IBD and rheumatoid arthritis. Watch the full video: https://bit.ly/4eBqjXi #immunology #inflammation #biotech

With articles delving into diverse topics under the new ‘Treatment of…’ series, Clinical & Experimental Immunology provides a comprehensive overview of immunopathology, treatment options, and future developments in immune-mediated diseases. Read the articles and learn how to submit your work: https://oxford.ly/4bVDeC8

Professor Thomas Rademacher sits down with the host of Progress, Potential, and Possibilities, Ira S Pastor, and describes how Emergex's innovative vaccine technology is setting a new standard in immunology, offering a groundbreaking approach to combatting highly mutagenic viruses such as flu and COVID-19 through T cell-priming. Professor Rademacher also gives some insight on his background including some of the biotech enterprises he founded and key advances in our understanding of molecular medicine and vaccine development. Tune into the interview to explore how Emergex’s strategy can potentially change the way we prepare for viral outbreaks: https://bit.ly/3JAVeVY #Emergex #RNA #Tcell

Join the University of Nairobi and the Univeristy of Colorado for a Symposium on Inborn Errors of Immunity, hosted by the Federation of Clinical Immunology Societies (FOCIS) 📅 Date: 25th October 2024 ⏰️Time: 6.00 - 9.00 pm EAT Register here: ow.ly/Onq950Tes0G Topics to be covered: Immune Diagnostics Based on Flow Cytometry - Phenotype & Functional Assays Immune Diagnostics Based on Genetics - Panels vs WES, Types of Results T Cell Development/Differentiation - SCID (incl Congenital Athymia) B Cell Development/Differentiation - Antibody Deficiencies, CVID Autoinflammatory Disorders - Inflammasome & Beyond Phagocyte Defects incl Neutropaenias

Inflammatory changes can be found in the bone marrow of a whole range of hematological malignancies 🔥 But why are the downstream effects so different? Tom Cupedo and I explore this question in our new review out in Nature Reviews Immunology, with brilliant help of Lanpeng Chen and Marc Raaijmakers sharing their expertise in MDS/AML We hope you enjoy! https://rdcu.be/dBkF2