Newcells Biotech Ltd

At Newcells Biotech, we accelerate drug discovery and clinical translation through advanced in vitro models and predictive testing services. 🔬Specialists in: 🔹Retinal, kidney and lung in vitro models 🔹Preclinical drug development testing 🔹Toxicology and disease modelling Trusted by leading pharma and biotech companies, we help you predict human outcomes with unmatched accuracy—saving time, costs, and lives. 🌟 Why Newcells? ✔️ Industry-leading expertise ✔️ Cutting-edge models tailored to your needs ✔️ Proven results in advancing drug discovery Ready to innovate with confidence? 👉 https://lnkd.in/d9Q35Pq #Newcells #DrugDiscovery #ClinicalTranslation #InVitroModels

🔹Light responsive retinal organoids for accurate prediction of clinical outcomes 👁 Human retinal organoids that are iPSC derived can recapitulate the complex structure of the human retina with laminar cell organisation mimicking embryonic development. Critically, they contain the outer photoreceptor segment of the retina that responds to light. These models that mimic the complex structure of the human retina, provide a powerful tool for understanding retinal diseases, drug safety, and gene therapy evaluation. Carefully designed studies using isogenic controls can provide a solid set of data to progress therapies through clinical translation. Learn more about how our cutting-edge retinal organoids can advance vision research with disease modelling, safety and efficacy testing. 👉 https://lnkd.in/eZ4eraE4 #Newcells #Retina #Organoids #VisionResearch #BiotechInnovation

The drug discovery process is being accelerated once more, and reliance on predictive in vitro models becomes even more significant with the FDA Modernisation Act 3.0 passing the US Senate. The FDA Modernization Act 3.0 is a bipartisan effort to reduce unnecessary animal testing while advancing scientific innovation. By fully implementing FDAMA 3.0, drug development can be both more humane and more efficient, ultimately leading to faster and more reliable treatments for patients. Read the full story here 👉 https://lnkd.in/ebW8ptFN The 3Rs Collaborative (3RsC) National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) FDA

At Newcells, we collaborate closely with our customers to address the strategically critical questions they want answered, ensuring that what the data we deliver for them is exactly what they need to take decisions. We're working with some of the leading companies in areas such as cell and gene therapy to providing them with in vitro complex models to demonstrate how these cutting- edge technologies impact the human body. The distinctive value that we bring to our customers is that the three platforms we use - retina, kidney, lung - are all based on the same biology. This enables us to work with customers through different stages of the drug discovery pipeline. What customers fundamentally find important is data and whether that data is predictive. Find out how Newcells ensures customer and industry requirements are met not just today, but in the future ▶️ https://lnkd.in/e-AwuYTP #Newcells #CellTherapy #GeneTherapy #DrugDiscovery

🔬Case Study: Transforming Drug Development with 3D Retina Models 👁 The CRACK IT: Retinal 3D challenge awarded us £1M to deliver 3D hiPSC (human-induced pluripotent stem cells) derived laminated retinal model as a tool for toxicology studies and that's exactly what we did..and more! The challenge was led by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), a UK-based scientific organisation dedicated to replacing, refining and reducing the use of animals in research and testing. The Ask❓ At the time, the development of drugs for eye disorders was growing expansively. However, there were no adequate in vitro models that could recapitulate the complex structure of the mature human retina. The Solution💡 We collaborated with Newcastle University and Loughborough University, Sunderland Eye Infirmary and Asymptote to generate human induce pluripotent stem cells (hiPSC) to create 3D retinal organoids that closely modelled the structure and function of the human retina, enabling the replacement of animals in the discovery of new ophthalmic drugs. This has now opened the door to even further developments and advancements in the field. Read the full case study here 👉 https://lnkd.in/e2-5yVHt #Newcells #DrugDevelopment #RetinaModels #AnimalTesting

🔬 Advancing Ocular Research with Human Neural Retina Models 🔬 Development of treatments for retinal diseases requires great precision, accuracy and personalisation. Human retina in vitro models such as Retinal pigmentum epithelium (RPE) can offer groundbreaking insights to viral vector efficacy prior to clinical trials. Validated healthy or diseases iPSC-derived RPE are highly differentiated, polarised and functional, allowing the generation of: 🔵 Predictive datasets suitable for IND submissions 🔵 Reliable results and confidence in viral vector selection Find our more here: https://lnkd.in/enEmm3dq #Newcells #DrugDiscovery #Ophthalmology #RetinaResearch #Organoids

How to best assess damage to lung airways? 🫁 Inhalation of toxic microparticles can damage lower airway epithelial cells. Sustained microinjury of the epithelium results in aberrant epithelial-fibroblast communication via the release of fibrotic stimuli, including TGF-β1. Get up to speed with the utilisation of high-content imaging for the study of lung fibrosis 👉 https://lnkd.in/ecX4vMsA #Newcells #EpithelialCells #LungFibrosis

In order to accurately predict drug efficacy and potential side effects it is important to: 💡 Understand how drugs are transported within the kidney 💡 Understand how drug-drug interactions may impact renal function 💡 Evaluate the effect of the compound on the whole physiology of the tissue Advanced nephron models therefore need to be able to accurately recapitulate the in vivo environment to accelerate the drug development processes. Using the most appropriate in vitro model has the potential to improve patient outcomes by providing more predictive results to identify more effective treatments. Through our innovative approach, researchers are able to gain a comprehensive set of data to confidently assess the impact of their compound on renal function by using our advanced complex nephron models from frersh tissue. 🟢 Benefits of our Proximal Tubule Cell model: 1. All major renal transporters are expressed at high levels , ensuring robust predictions 2. Available for different pre-clinical species enabling cross-species comparison 3. Predictive data for renal drug handling, DDI and kidney safety Our expertise in drug safety studies in nephron models can support your specific requirements. Discover how: https://lnkd.in/df_z9ZnR #NewcellsBiotech #Kidney #DrugDiscovery #BiotechInnovation

🗞 | Renal Creatinine Clearance Pathway: Pfizer - Newcells collaboration data published 🗞 The resulting publication of a collaboration between Newcells Biotech and Pfizer PDM looking at creatinine transport in vitro is set to have a significant impact for the industry. The team of scientists studied the uptake of creatinine in vitro using freshly isolated human PTCs displaying functional OCT2 and OAT2 transporter activity. 🔎Discover their findings for: -primary pathway for creatinine basolateral uptake in vitro -the pathways that mechanistic models should focus on when assessing kidney function and drug interactions #Newcells #Kidney #KidneyResearch #Pfizer #DrugInteractions

🔬Unlocking Insights into Fibrosis: The high-throughput high-sensitivity FMT Assay This assay provides critical insights into fibrotic diseases, outlining the importance of using culture conditions that promote fibroblast activation and matrix deposition for accurate protein detection and quantification results. 🔍Why Choose Newcells’ Advanced FMT Assay? ✔️High sensitivity: Accurately select which compound to progress to target idiopathic pulmonary fibrosis (IPF) and fibrosing lung disease. ✔️High-Throughput Imaging: Reliable and rapid quantification using a 384-well format. ✔️Translational Insights: 4 data otuputs. Establish a link between RNA expression and protein expression changes. Learn more here: https://lnkd.in/ePdxzcZm #Newcells #Lung #FibrosisResearch