CASCINATION

The anticipated moment has arrived – 10,000 patients have been treated with CAS-One IR. We are thankful for the ~200 physicians around the world in 65 hospitals who believe in our technology and the concept of Quality Ablation. Our team is hard at work with more and more plans to continue to make tumor ablation better for patients.

We loved ESIR in Innsbruck last week! Seriously interested participants spending dedicated time walking through how Quality Ablation with CAS-One IR works – our station was led by Dr. Marie Beermann who has performed close to 1,000 Quality Ablations herself as well as Dr. Philipp Wiggermann, whose experience in stereotaxy and robotics goes back many years. We were privileged to use our software in a second workshop station dedicated to image fusion (CT/CT and CT/MRI), Dr. Bruno Odisio took the lead here. We look forward to seeing Reto Bale and Cardiovascular and Interventional Radiological Society of Europe in Innsbruck again in 2 years time! Ted Farwell Thijs Stoker Stefan Weber

Welcome to Quality Ablation Ministry of National Guard Health Affairs (MNGHA) - Riyahd! The first hospital in the Arab world to start using CAS-One IR. Thanks to the whole team especially DR. SHAKER ALSHEHRI, Dr. AbdulRahman Alvi, and Dr. Abdulrahman Alqahtani. Thijs Stoker and Stijn Van Hertem supported their first 5+ cases over the last few weeks and we look forward to the future. This would not be possible without our partner IntelMed, and especially kholoud hassan. Najib HANNOUCH Stefan Weber

CAS-One IR was present at the first Medpeers event in Amsterdam last week which went smoothly with excellent video cases and discussion from the faculty. Congrats to Prof. Martijn Meijerink and Dr. Susan van der Lei for the organization and execution. Yno Prevoo is shown here celebrating for his Needle Ninja competition win, where he also recorded a best ever (tie) score on the CAS-One IR AI challenge (50+ participants!) Thijs Stoker Ted Farwell Patricia Navarro Martín

Prof. Attila Kovács at WEGE KLINIK used their new Philips 7500 Spectral CT for the first time on Tuesday, and decided the very first patient treated would be a patient with an 8cm retroperitoneal metastasis treated with a 12-needle ECT with the help of CAS-One IR. Two more patients were treated with ECT that same day, all under General Anaesthesia, and the consistency of a CAS-One IR treatment even allowed for time left for a 4th patient (liver biopsy). It is always good to see WEGE KLINIK and Prof. Kovacs utilizing new technology to improve tumor treatments for patients, and we expect many more success stories to come. A special thanks to our Head of Clinical Application, Thijs Stoker for assisting in these cases. Ahmet Gürle Ted Farwell Christian Baron Kaschuba Anja Karola Kütting Philips IGEA S.p.A.

November’s Top Case: A 57-year-old with rectal cancer with a history of surgery and chemo was scheduled for MWA of 5 remaining metastasis. 6 trajectories were planned and verified with CAS-One IR, and AblaSure showed sufficient coverage. Thanks to Dr. Ádám Zoltán Farkas at Semmelweis University Hospital. Full case report in the comments. Pál Ákos Deák Mélissa Golin Christoph Thiede ECO Microwave

Welcome to Quality Ablation Norrlands Universitetssjukhus / Umeå University! The team completed their first case today in under 1 hour, with excellent results (AI-driven AblaSure showed 97% margin coverage). The majority of their patients will now be done with the aid of CAS-One IR, and more liver and kidney patients will be able to be treated as well. Thanks to Oskar Hemmingsson, Bengt Lind, Emma Lundmark, Hanna Nystrom, Ann-Catrine Strandén, Anna Molin, and many others from radiology and anaesthesia who have invested time and effort to kick off this project. Stay tuned for a more in-depth interview with the team and how Quality Ablation with CAS-One IR will positively impact their patients and their hospital. Trine Bergwall Margrethe Kallestad Rasmussen

The team at UZA led by Prof. Thiery Chapelle has treated over 300 patients with CAS-One IR – mostly lesions in the liver. However, every year there are a few IRE Pancreas treatments done as well – like this one completed last week. The complexities of these cases (trans-hepatic approach, 4 needles, highly accuracy/parallelism dependant) would seemingly make them challenging, but with CAS-One IR they are done relatively simply, and relatively fast (2.5 hours). Maybe we will soon feature this as a top case? Bart op de Beeck bart bracke Stijn Van Hertem Mélissa Golin Thijs Stoker Sebastian Koch AngioDynamics International

Happy Halloween from all of us at CASCINATION! Patricia Navarro Martín Ted Farwell Benjamin E. Vladislav Vaduvescu

October’s Top Case: A 59-year-old with CRC initially considered a palliative patient had a good response to chemotherapy and the tumor board decided with CAS-One IR it was possible to treat the liver metastases. IRE was performed for the central lesion, and MWA for the remaining lesions, done in the same session. Both MRI fusion and ablation confirmation with AblaSure were utilized, helping the case to be successful. Thanks to Dr Marie Beermann and the team at Danderyds Sjukhus AB for performing this case. Full case report in the comments. Trine Bergwall Margrethe Kallestad Rasmussen jacob freedman AngioDynamics International Mediplast AB