ADORA2A

ADORA2A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2YDO, 2YDV, 3EML, 3PWH, 3QAK, 3REY, 3RFM, 3UZA, 3UZC, 3VG9, 3VGA, 4EIY, 4UG2, 4UHR, 5IU4, 5IU7, 5IUA, 5IU8, 5IUB
Dynodwyr
Cyfenwau	ADORA2A, adenosine A2a receptor, A2aR, ADORA2, RDC8
Dynodwyr allanol	OMIM: 102776 HomoloGene: 20166 GeneCards: ADORA2A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled adenosine receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • enzyme binding; • alpha-actinin binding; • type 5 metabotropic glutamate receptor binding; • protein heterodimerization activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • integral component of plasma membrane; • intermediate filament; • endomembrane system; • GO:0097483, GO:0097481 postsynaptic density; • axon; • dendrite; • axolemma; • asymmetric synapse; • presynaptic membrane; • soma; • postsynaptic membrane; • presynaptic active zone; • integral component of postsynaptic membrane; • integral component of presynaptic membrane; • glutamatergic synapse; • Golgi membrane;
Prosesau biolegol	• cAMP biosynthetic process; • G protein-coupled adenosine receptor signaling pathway; • sensory perception; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • cell-cell signaling; • blood coagulation; • blood circulation; • cellular defense response; • central nervous system development; • ffagocytosis; • inflammatory response; • GO:0072468 signal transduction; • GO:0097285 apoptotic process; • synaptic transmission, dopaminergic; • response to amphetamine; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of protein kinase activity; • protein kinase C-activating G protein-coupled receptor signaling pathway; • synaptic transmission, cholinergic; • locomotory behavior; • negative regulation of cell population proliferation; • positive regulation of glutamate secretion; • positive regulation of acetylcholine secretion, neurotransmission; • regulation of norepinephrine secretion; • response to caffeine; • positive regulation of synaptic transmission, GABAergic; • synaptic transmission, glutamatergic; • positive regulation of urine volume; • positive regulation of renal sodium excretion; • negative regulation of locomotion; • vasodilation; • eating behavior; • negative regulation of vascular permeability; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to alkaloid; • GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of circadian sleep/wake cycle, sleep; • negative regulation of alpha-beta T cell activation; • astrocyte activation; • neuron projection morphogenesis; • positive regulation of protein secretion; • negative regulation of inflammatory response; • regulation of mitochondrial membrane potential; • membrane depolarization; • regulation of calcium ion transport; • positive regulation of synaptic transmission, glutamatergic; • excitatory postsynaptic potential; • inhibitory postsynaptic potential; • prepulse inhibition; • positive regulation of apoptotic signaling pathway; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of long-term synaptic potentiation; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologau
	135
	n/a
	ENSG00000128271
	n/a
	P29274
	n/a
	NM_000675; NM_001278497; NM_001278498; NM_001278499; NM_001278500
	n/a
	NP_000666; NP_001265426; NP_001265427; NP_001265428; NP_001265429
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADORA2A yw ADORA2A a elwir hefyd yn Adenosine receptor A2a , Adenosine receptor A2 ac Adenosine A2a receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q11.23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADORA2A.

A2aR
RDC8
ADORA2

Llyfryddiaeth

"Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. ". Neurobiol Aging. 2017. PMID 28941407.
"Hypoxic postconditioning attenuates apoptosis via activation of adenosine A2a receptors on dermal microvascular endothelial cells of human flaps. ". J Surg Res. 2017. PMID 28606618.
"Early tyrosine phosphorylation events following adenosine A2A receptor in human neutrophils: identification of regulated pathways. ". J Leukoc Biol. 2017. PMID 28179537.
"A3 adenosine receptor agonist, CF102, protects against hepatic ischemia/reperfusion injury following partial hepatectomy. ". Mol Med Rep. 2016. PMID 27666664.
"Structure of the adenosine A(2A) receptor bound to an engineered G protein.". Nature. 2016. PMID 27462812.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ADORA2A - Cronfa NCBI

[1]

[2]