SB-408,124

SB-408,124
(IUPAC) ime
	N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Klinički podaci
Identifikatori
CAS broj	288150-92-5
ATC kod	?
Hemijski podaci
Formula	C19H18F2N4O
Mol. masa	356.368 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26) ; Key: JTARFZSNUAGHRB-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

SB-408,124 je lek koji je ne-peptidni selektivni antagonist oreksinskog receptora, tipa OX₁. On je oko 70 puta selektivniji za OX₁ nego OX₂ receptor, ima poboljšanu oralnu biodostupnost u poređenju sa starijim OX₁ antagonistom SB-334,867. On se koristi u naučnim istraživanjima funkcije oreksinergičkih neurona u telu.^[1]^[2]

Literatura

↑ Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). „Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor”. British journal of pharmacology 141 (2): 340–6. DOI:10.1038/sj.bjp.0705610. PMC 1574197. PMID 14691055.
↑ Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH i dr.. (2008). „Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit”. American journal of physiology. Endocrinology and metabolism 295 (1): E117–29. DOI:10.1152/ajpendo.90243.2008. PMID 18477704.

Vanjske veze

	Portal Medicina
	Portal Hemija

Šablon:Neuropeptidni ligandi

[1] Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). „Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor”. British journal of pharmacology 141 (2): 340–6. DOI:10.1038/sj.bjp.0705610. PMC 1574197. PMID 14691055.

[2] Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH i dr.. (2008). „Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit”. American journal of physiology. Endocrinology and metabolism 295 (1): E117–29. DOI:10.1152/ajpendo.90243.2008. PMID 18477704.

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