Metergolin

Metergolin
(IUPAC) ime
	[(8β)-1,6-dimethylergolin-8-yl]methyl}carbamate
Klinički podaci
Identifikatori
CAS broj	17692-51-2
ATC kod	?
PubChem	28693
ChemSpider	26687
UNII	1501393LY5
ChEMBL	CHEMBL19215
Hemijski podaci
Formula	C25H29N3O2
Mol. masa	403.52 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1 ; Key: WZHJKEUHNJHDLS-QTGUNEKASA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Metergolin je psihoaktivni lek iz ergolinske hemijske klase koji deluje kao ligand na raznim serotoninskim i dopaminskim receptorima.^[5]^[6]

Povezano

Mesulergin

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Hamon M, Mallat M, Herbet A, et al. (February 1981). „[3H]Metergoline: a new ligand of serotonin receptors in the rat brain”. Journal of Neurochemistry 36 (2): 613–26. DOI:10.1111/j.1471-4159.1981.tb01634.x. PMID 7463079.
↑ Miller KJ, King A, Demchyshyn L, Niznik H, Teitler M (1992). „Agonist activity of sumatriptan and metergoline at the human 5-HT_1D beta receptor: further evidence for a role of the 5-HT_1D receptor in the action of sumatriptan”. Eur. J. Pharmacol. 227 (1): 99–102. DOI:10.1016/0922-4106(92)90149-P. PMID 1330643.

Vanjske veze

	Portal Medicina
	Portal Hemija

MeSH Metergoline

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid7463079-5] Hamon M, Mallat M, Herbet A, et al. (February 1981). „[3H]Metergoline: a new ligand of serotonin receptors in the rat brain”. Journal of Neurochemistry 36 (2): 613–26. DOI:10.1111/j.1471-4159.1981.tb01634.x. PMID 7463079.

[pmid1330643-6] Miller KJ, King A, Demchyshyn L, Niznik H, Teitler M (1992). „Agonist activity of sumatriptan and metergoline at the human 5-HT_1D beta receptor: further evidence for a role of the 5-HT_1D receptor in the action of sumatriptan”. Eur. J. Pharmacol. 227 (1): 99–102. DOI:10.1016/0922-4106(92)90149-P. PMID 1330643.

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