AlBaraa Tayallah’s Post

UNC1999 is an effective, selective, and SAM-competitive EZH2 and EZH1 inhibitor with IC50 values of<10 nM and 45 nM,respectively.UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation,and apoptosis. #UNC1999 #proliferation #SAM #competitive #EZH2 #leukemia https://lnkd.in/gf82Gbfn

Living with carcinoid syndrome means managing daily challenges that impact quality of life, from persistent flushing and diarrhea to serious heart complications. The current standard of care is burdensome, involving depot injections of somatostatin peptide analogs that are associated with injection pain, inconsistent exposure, and breakthrough symptoms. At Crinetics, we are advancing research on an investigational, once-daily, nonpeptide, oral selective SST2 agonist, which is being studied for its potential to address the needs of patients with #CarcinoidSyndrome. Learn more: https://bit.ly/4cTcdzP  

1)Defensive Factor Enhancers ( Mucosal protective agents) These agents protect and support healing of the stomach lining without directly reducing acid.They include sucralfate, which forms a protective gel on damaged areas;misoprostol,which boosts mucus and bicarbonate production; and bismuth containing compounds, which create a Barrier and offer antibacterial effects against H.pylori. 2)Aggressive Factor Inhibitors(Acid suppressants).      These inhibitors work by reducing stomach acid production, which helps minimize irritation to the stomach lining. Common medications in this category include proton pump inhibitors(PPI's),H2 receptor anatgonist,P-CABs(Potassium-competitive acid blockers) and antacids.

Treatment of antibody-Mediated Rejection (AMR) : Depends on hemodynamic impact, presence of DSAs, and grade of AMR. 1-Remove circulating alloantibodies → PLEX. 2-Neutralize circulating alloantibodies → IVIg. 3-Suppress T-cell responses → steroids, MMF, ATG. 4-Suppress or deplete B-cells → Steroids, rituximab, splenectomy. 5-Suppress or deplete plasma B-cells → Bortezomib. 6-Inhibition of complement → Eculizumab, IVIg.

ORAL GLYCOPROTEIN IIb/IIIa ANTAGONISTS ::   The development of prodrugs with RGD specificity has provided oral agents including xemilofiban orbofiban and sibrafiban demonstrating longer half -lives (approximately 2 to 4 hrs) and predominantly renal excretion However the P1A2 genotype of the GP IIb/IIIa receptor appears to be associated with adverse outcome in patients treated with oral GP IIb /IIIa antagonist Thus P1A2 https://lnkd.in/d48Fvpka

Part 3/3 Why is an ANGIOTENSIN 2 RECEPTOR BLOCKER combined with a NEPRILYSIN INHIBITOR for Heart failure GDMT? Sacubitril inhibits the enzyme Neprilysin, which degrades vasoactive peptides, including Bradykinin, Natriuretic peptides & Angiotensin 2. This inhibition leads to increased plasma concentrations of these peptides: ↑ Bradykinin & Natriuretic peptides→ Vasodilation & Natriuresis/ Diuresis ↑ Angiotensin 2 augments the Angiotensin− Aldosterone system, opposing the above effects via vasoconstriction w/ renal NaCl & water retention Attempts to treat Heart failure w/ a Neprilysin inhibitor alone were unsuccessful in reducing morbidity/ mortality, thought likely due to the inhibition of Angiotensin 2 breakdown, antagonizing their beneficial effects due to the accumulation of Angiotensin 2 & Aldosterone Subsequent combination w/ an ACEi ↑ the risk of Angioedema due to the dual inhibition of Bradykinin metabolism The current combination w/ an ARB (Valsartan) produces greater vasodilation & natriuresis/ diuresis, while avoiding the unintended augmentation of Angiotensin−Aldosterone system Visit our Website/ Medical wards app knowmedicine.net #medicalstudent #medicalresident #meded #medicalschool #internalmedicine #medicaleducation #medstudent #imresidency #medicalapp #foamed #hospitalist #hospitalmedicine #gdmt

Acccording to Co pilot - Insulin resistance Insulin Resistance and NO: Insulin resistance is associated with reduced NO bioavailability and endothelial dysfunction. But maybe the reduced nitic oxide (seen in diabetes) is due to so much being bound to hemoglobin and the insulin receptors NO is there but unavailable due to being bound to the insulin receptor and or hemoglobin And then again - the insulin receptor - has too much NO bound to it to operate correctly. availability of NO - unbound and mitochondrial respiration increases Again red light therapy dislodges nitric oxide from hemoglobin for better cellar respiration and glycogen storage and it my dislodge nitric oxide from insulin receptors

Assess the effectiveness of pancreatic enzyme replacement therapy (PERT) in patients with pancreatic exocrine insufficiency (PEI) through a comprehensive review as part of this mini-audit. Unlock 4.5 CPD hours upon completion: https://bit.ly/47QX2nq #pert #cpd #cme #meded #gp

1- We suggest using acid suppression prophylaxis for people with higher risk of gastrointestinal bleeding (4% or higher) --- 2- In critically ill patients who are going to receive prophylaxis against gastrointestinal bleeding, we suggest a proton pump inhibitor. A histamine-2 receptor antagonist is also a reasonable choice. We recommend not using sucralfate

Ophthopedia Update:Evaluating the Efficacy and Safety of Aflibercept Biosimilar (P041) Compared to Originator Product in Patients with Neovascular Age-related Macular Degeneration: To assess the non-inferiority of biosimilar aflibercept (CinnaGen Company, Iran) (P041) to the originator aflibercept (Regeneron, US) (AFL) in terms of efficacy, safety, and immunogenicity. #Ophthalmology #Retina #Ophthotwitter