Axoft

Today, we’re sharing some momentous news: Our first-in-human clinical study has been approved and will take place in early 2025 at The Panama Clinic. The study will demonstrate the usability of our novel, brain-like materials and marks the first time this type of bio-inspired material is authorized for use in humans. Our goal with this study is to generate initial safety data and show that our implantable Brain-Computer Interface (iBCI) can be used to decode neural signals in humans, while minimizing disruption to the brain and integrating with existing surgical workflows. Participants will include patients undergoing existing brain resection surgery, during which we intend to decode volitional brain activity. We’re proud of our team’s relentless dedication to making iBCIs safer and more effective, while also ensuring they’re user-friendly and not overengineered. This clinical translation is a big milestone that brings us closer to helping the millions of patients suffering from untreatable chronic neurological disorders. Thank you to our partners in this study, Dr. Ricardo Bermudez, his team at The Panama Clinic, and bioaccess® LATAM MEDTECH CRO®. If you’d like to learn more about today’s news, view our press release here: https://lnkd.in/gCi4znTh

Our co-founder and CEO Paul Le Floch represented Axoft at the 70th annual IEDM Conference in San Francisco, where he spoke about the need to develop novel, soft materials to improve the stability and performance of implantable brain-computer interfaces (iBCIs). His presentation included results on the long-term stability of soft neural interfaces and their ability to track single-neuron activity over multiple years in preclinical models, as illustrated in this video, and a newly published technical paper that outlined: - How current, state-of-the-art, thin-film electronics rely on rigid materials with limited biocompatibility, which hinders the design of scalable neural interfaces. - Why building high-density, chronically stable probes for tissue-wide neural interfaces is key for improving the efficacy of implantable BCIs, discovering neural biomarkers for diagnostics and developing patient-specific neuromodulation therapies. - How Axoft’s soft, biocompatible, high-performance dielectric materials are specifically designed to overcome the typical trade-off between bandwidth and stability in implantable neural interfaces. We’re proud to share more about the new class of materials Axoft is developing to overcome the long-standing limitations of BCIs – for both physicians and patients suffering from chronic neurological disorders. The full technical paper will soon be available on https://lnkd.in/ekyezCa. To learn more about our novel materials or to inquire about open development partnership opportunities, visit https://axoft.us/.

Axoft's Paul Le Floch joined the #BCI panel discussion at #CRANIAconf2024 organized by The CenteR for Advancing Neurotechnological Innovation to Application in Toronto last week where he spoke alongside key opinion leaders Angelique Christine Paulk, Dejan Markovic, IEEE, AIMBE Fellow, Jose Zariffa and Sridevi Sarma on the state and future of implantable Brain-Computer Interfaces in clinical applications. Thank you to Alfonso Fasano for moderating this discussion with such energy! While the technological innovations and first use cases enabling the #BCI revolution are generally agreed upon, the key message to remember will be "It all starts and ends in the clinic", emphasizing the importance of adopting a user-centric design in #neurotechnology. The conference also brought together Axoft's clinical collaborators, the Krembil Research Institute with Taufik Valiante and Homeira Moradi Chameh's N2BL team, as well as the Massachusetts General Hospital with Angelique Christine Paulk, illustrating the advantages of #bioinspired #soft neural probe for high-resolution depth neural recordings during both presentation and poster sessions. #CRANIAconf2024 #BCI #neuromodulation #neuroscience #brain

We are absolutely thrilled to have Rongchen Huang joining us as Neuroscientist! Prior to Axoft, Rongchen was a Postdoctoral Researcher and Ph.D. graduate in #neuroscience from University of Colorado Anschutz Medical Campus, where she investigated the effect of vagus nerve stimulation on axonal selection for myelin repair and other neuronal functions with high channel count implantable neural interfaces and modern imaging techniques.

🚨 Short-term job alert in Cambridge, MA! 🚨 Looking for an extra pair of hands to package devices for 1-2 weeks starting TOMORROW! If you're in the Boston area and available, reach out to me or Andrew Spencer via DM. Requirements: - Location: Cambridge, MA - Duration: 1-2 weeks - Start Date: Tomorrow! - Experience required: Ability to follow a protocol and being dexterous #JobOpening #ShortTermJob #CambridgeMA #BostonArea #HiringNow

We are thrilled to have Julian Bär joining the ranks of our #microfabrication division lead by Hyunsu Park, to further develop Axoft's high channel count #soft neural interface. Julian holds a Bachelor of Science in micro-engineering from EPFL and is currently completing is Master of Science in the Neuro-X program. Welcome to the #Team!

Wishing a warm #welcome to Anika Parekh, Polymer Chemist Co-Op at Axoft, joining the group of Foad Vashahi! Anika is currently completing her bachelor's degree with a major in Chemistry at Northeastern University.

A beautiful venue for a great conference! Find us a Neuromodec 2024 at the The City College of New York today, and tomorrow for the poster session, where we present Axoft's progress toward its deep brain neural interface. It includes a glimpse on our first high-resolution recordings from #human #brain tissues and #neurons, using our #ultrasoft probes, in collaboration with the fantastic team of Dr. Taufik Valiante and support of Homeira Moradi Chameh at the Krembil Research Institute!

Happy Birthday to Axoft! Many thanks to all #team members, supporters, and investors who have contributed to our #success over the years. We are excited to bring our #soft neural interface a little bit closer to the clinic every day, to develop better ways to diagnose and treat chronic neurological disorders. What's even better than a birthday cake? Our long-term stable, high-resolution brain recordings in preclinical models!