Vegan Low-Fat Daily Soy Diet: Foods Beneficial for Postmenopausal Women | Latest news for doctors, nurses and pharmacists

A dietary intervention consisting of a plant-based diet, minimal oils, and daily soybeans appears to have favorable effects on vasomotor symptoms and menopause-related quality of life, as reported in one study.

“Dietary intervention resulted in clinically significant reductions in menopausal symptoms. Of particular note was the 88% reduction in moderate to severe vasomotor events among participants in the intervention group, accompanied by weight loss and improvements in physical, psychosocial and sexual domains,” according to the investigators. .

The way diet can prevent vasomotor symptoms can be explained by “the fact that in premenopausal women, increased dietary fat increases circulating concentrations of estradiol, while dietary fiber reduces these concentrations, suggesting the possibility that chronic elevations in estrogen levels during childbearing years may increase vulnerability”. to vasomotor symptoms at menopause,” they pointed out. [Am J Clin Nutr 1991;54:520-525;
Cancer 1995;76:2491-2496]

In the study, investigators randomized 84 postmenopausal women who reported at least two moderate-to-severe hot flashes per day to undergo dietary intervention (mean age 53.2 years) or to make no dietary change (control; n = 42, mean age 55.2 years). years) for 12 weeks.

Participants in the intervention group were instructed to avoid foods of animal origin, minimize the use of oils and fatty foods (eg, nuts and avocados), and consume 1/2 cup (86 g) of cooked non-genetically modified whole soybeans. Both the intervention group and the control group were asked to use a mobile app to record hot flashes (frequency and severity). They also completed the Menopause-Specific Quality of Life Questionnaire (MENQOL) to provide information on vasomotor, psychosocial, physical, and sexual symptoms.

At week 12, moderate to severe hot flashes in the intervention group decreased by 88% from baseline (pMenopause 2022;doi:10.1097/GME.0000000000002080]

Half of the graduates who followed the diet reported a complete absence of moderate to severe hot flashes at the end of the intervention. In contrast, no member of the control group achieved this result.

The researchers noted that the degree of improvement in hot flashes was not associated with seasonality – so cooler temperatures did not appear to induce symptomatic improvement – ​​or with equol production. Rather, correlations were observed between the evolution of hot flushes and that of body weight (p=0.002).

Finally, the intervention group experienced greater changes in the vasomotor (p=0.004), physical (p=0.01), and sexual (p=0.03) domains of MENQOL compared to the control group.

“The present study extends the results of the original study cohort by providing a larger sample size, ruling out seasonality in the reduction of vasomotor symptoms, and providing initial data regarding equol,” the investigators said. [Menopause 2021;28:1150-1156]

However, they admitted that the inclusion criteria required at least two moderate to severe vasomotor events per day, fewer than the seven to eight events recommended by the US Food and Drug Administration for therapeutic trials.

“The present study may therefore be more informative for women with less frequent events and less informative for those with more frequent events. robust in this subpopulation,” the researchers said.