Bi/ond

𝗡𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻𝘁𝗼 𝗗𝘂𝗰𝗵𝗲𝗻𝗻𝗲 𝗠𝘂𝘀𝗰𝘂𝗹𝗮𝗿 𝗗𝘆𝘀𝘁𝗿𝗼𝗽𝗵𝘆 (𝗗𝗠𝗗) 𝗮𝗿𝗲 𝗽𝗼𝘀𝘀𝗶𝗯𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗼𝗻 𝟯𝗗 𝘀𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗺𝘂𝘀𝗰𝗹𝗲 𝗺𝗼𝗱𝗲𝗹𝘀! In our latest research study, in collaboration with bit.bio, Bi/ond scientists have discovered how 𝗶𝗼𝗦𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗠𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝗰𝗮𝗻 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝟯𝗗 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗺𝗶𝗰𝗿𝗼𝘁𝗶𝘀𝘀𝘂𝗲𝘀, 𝗲𝘅𝗵𝗶𝗯𝗶𝘁𝗶𝗻𝗴 𝘁𝘄𝗶𝘁𝗰𝗵 & 𝘁𝗲𝘁𝗮𝗻𝗶𝗰 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗵𝗮𝘁 𝘀𝘁𝗿𝗲𝗻𝗴𝘁𝗵𝗲𝗻 𝗼𝘃𝗲𝗿 𝘁𝗶𝗺𝗲. This poster highlights the results of their work. What you'll learn: ✅ How iPSC-derived cells were used in the Bi/ond OoC culture system ✅ Functional & phenotypic readouts using the MUSbit™ chip ✅ Real-world applications for disease model research Key Findings: 🔬 Impaired 𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗶𝗼𝗻 profiles in DMD models 🔬Functional activity restored through 𝗲𝘅𝗼𝗻 𝗱𝗲𝗹𝗲𝘁𝗶𝗼𝗻𝘀 🔬Advanced in vitro tools for 𝗗𝗠𝗗 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 & 𝗱𝗿𝘂𝗴 𝘀𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 Dive into the full poster for inspiration for your own research!  📥 𝗗𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗡𝗼𝘄! https://lnkd.in/eW-fAJmi #DMD #DrugDevelopment #iPSC #OrganOnChip #3DBiology #PharmaResearch #biotech #MUSbit

Wishing you a Happy New Year filled with innovation, success, and a pinch of magic! Tell us in the comments: what are your 2025 business resolutions? #gobiond #HNY #resolutions

Did 2024 fly by as quickly for you as it did for us? 💫 It wasn’t all a walk in the park—this year was busy and challenging, but that’s where we thrive! As we celebrate the end of another successful year, we want to express our gratitude for our team's tireless efforts and dedication. We are incredibly proud of their work in improving existing products, expanding our product range, and achieving remarkable scientific results through collaborations with industry partners and research institutions. We’re proud to see how our team’s strong cohesion, combined with our partnerships and global client involvement, is blending diverse skills and capabilities into a shared vision for the future of biotech. Looking ahead, we’re confident we’ll have even greater accomplishments to share with you. Thank you for walking alongside us in 2024. Best wishes for the holidays! #gobiond #endofyear #2024inreview

Would you like to have the opportunity to 𝘀𝗵𝗮𝗽𝗲 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁-𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗢𝗿𝗴𝗮𝗻-𝗼𝗻-𝗮-𝗖𝗵𝗶𝗽 𝗽𝗹𝗮𝘁𝗲 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 with your input and suggestions?? Look no further! ⬇️ Soon, we will be releasing a survey that delves into key aspects of OoC plate design such as, 𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁, 𝗲𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝗮𝗻𝗱 𝗳𝗹𝘂𝗶𝗱𝗶𝗰 𝘀𝘁𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻, 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝘀𝗲𝗻𝘀𝗼𝗿 𝗶𝗻𝘁𝗲𝗴𝗿𝗮𝘁𝗶𝗼𝗻. Your ideas will help us in the design of our future platforms. What better way to influence the field of microfluidics and 3D culture than to share your thoughts with a company at the forefront of these technologies. 𝗜𝗳 𝘆𝗼𝘂 𝘄𝗮𝗻𝘁 𝘁𝗼 𝗯𝗲 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱 𝗮𝗻𝗱 𝗺𝗮𝗸𝗲 𝘀𝘂𝗿𝗲 𝘆𝗼𝘂𝗿 𝘃𝗼𝗶𝗰𝗲 𝗶𝘀 𝗵𝗲𝗮𝗿𝗱, 𝗹𝗲𝘁 𝘂𝘀 𝗸𝗻𝗼𝘄 𝗶𝗻 𝘁𝗵𝗲 𝗰𝗼𝗺𝗺𝗲𝗻𝘁𝘀 ⬇️⬇️⬇️ 𝗮𝗻𝗱 𝘄𝗲 𝘄𝗶𝗹𝗹 𝘀𝗲𝗻𝗱 𝘆𝗼𝘂 𝘁𝗵𝗲 𝗹𝗶𝗻𝗸 𝗶𝗻 𝘁𝗵𝗲 𝗻𝗲𝘄 𝘆𝗲𝗮𝗿! #RandD #newproductdevelopment #OoC #survey #voc #nextgeneration #gobiond #3Dculture

Have you experienced bubbling during flow experiments? This could be related to your tubing. Here are a few tips from Anish Ballal to help you troubleshoot in these circumstances. PS: ask away in the comments if you have other questions! #ooc #flow #gobiond #tips #ooctips #troubleshoot

Vandria SA is a biopharmaceutical company that develops 𝗯𝗲𝘀𝘁-𝗶𝗻-𝗰𝗹𝗮𝘀𝘀 𝘀𝗺𝗮𝗹𝗹 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗲 𝗺𝗶𝘁𝗼𝗽𝗵𝗮𝗴𝘆 𝗶𝗻𝗱𝘂𝗰𝗲𝗿𝘀 𝘁𝗼 𝘁𝗿𝗲𝗮𝘁 𝗮𝗴𝗲-𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝗮𝗻𝗱 𝗰𝗵𝗿𝗼𝗻𝗶𝗰 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗲𝗹𝗱𝘀 𝗼𝗳 𝗠𝘂𝘀𝗰𝗹𝗲- 𝗮𝗻𝗱 𝗖𝗡𝗦 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀 with large unmet medical need. Vandria patented a range of small molecules that specifically target muscle, the brain, and other tissues. Their age related and chronic disease focus covers conditions such as ALS or Sarcopenia, amongst others. The Swiss company recently received grants worth 3.8M from Innosuisse and Eurostars which allows them to advance their innovative drug programs. Bi/ond is proud to work together with Vandria (and other consortium partners *) to generate 𝗽𝗿𝗲-𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗱𝗮𝘁𝗮 𝘁𝗵𝗮𝘁 𝘄𝗶𝗹𝗹 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘁𝗵𝗲𝗶𝗿 𝗺𝗶𝘁𝗼𝗽𝗵𝗮𝗴𝘆 𝗱𝗿𝘂𝗴 𝗰𝗮𝗻𝗱𝗶𝗱𝗮𝘁𝗲 𝗩𝗡𝗔-𝟬𝟱𝟮. The drug candidate is expected to 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝗺𝘂𝘀𝗰𝗹𝗲 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗶𝗻 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗶𝘁𝗵 𝗺𝘂𝘀𝗰𝗹𝗲 𝗽𝗮𝘁𝗵𝗼𝗹𝗼𝗴𝗶𝗲𝘀 𝗼𝗳 𝗵𝗶𝗴𝗵 𝘂𝗻𝗺𝗲𝘁 𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗻𝗲𝗲𝗱𝘀. The work is performed under the umbrella of the 𝗘𝘂𝗿𝗼𝘀𝘁𝗮𝗿𝘀 𝗠-𝗣𝗟𝗨𝗦 (𝟰𝟵𝟭𝟯) 𝗽𝗿𝗼𝗷𝗲𝗰𝘁. Read more about Vandria's pipeline and the science behind it in their website: https://www.vandria.com/ #chronicdisease #musclepathology #agerelated #collaboration #eurostars #gobiond * Biomeostasis and Greater Paris University Hospitals - AP-HP are, together with Vandria and Bi/ond, the members of the consortium that received Eurostars funding. 

𝗠𝘂𝘀𝗰𝗹𝗲 𝗿𝗲𝗽𝗮𝗶𝗿 𝘄𝗶𝘁𝗵𝗼𝘂𝘁 𝘀𝘁𝗲𝗺 𝗰𝗲𝗹𝗹𝘀? Contrary to the current paradigm that indicates that muscle repair and regeneration is driven by satellite cells, this group (*see authors below) showed that 𝗺𝘂𝘀𝗰𝗹𝗲 𝗳𝗶𝗯𝗲𝗿𝘀 𝗮𝗹𝘀𝗼 𝗵𝗮𝘃𝗲 𝗮 𝘀𝗲𝗹𝗳-𝗿𝗲𝗽𝗮𝗶𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺. The team of scientists studied 𝗵𝗼𝘄 𝘁𝗵𝗲 𝗺𝘂𝘀𝗰𝗹𝗲𝘀 𝗮𝗿𝗲 𝗿𝗲𝗽𝗮𝗶𝗿𝗲𝗱 𝗮𝗳𝘁𝗲𝗿 𝗶𝗻𝗷𝘂𝗿𝘆. They did this by either isolating muscle fibers from a mouse after exercise, or by artificially damaging muscle fibers in vitro with a laser. Additionally, they studied 𝗵𝗼𝘄 𝘁𝗵𝗲 𝗱𝗮𝗺𝗮𝗴𝗲 𝗴𝗲𝘁𝘀 𝗿𝗲𝗽𝗮𝗶𝗿𝗲𝗱 𝘂𝘀𝗶𝗻𝗴 𝗹𝗶𝘃𝗲-𝗰𝗲𝗹𝗹 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘁𝗲𝗰𝗵𝗻𝗶𝗾𝘂𝗲𝘀 𝘀𝘂𝗰𝗵 𝗮𝘀 𝘁𝗿𝗮𝗰𝗸𝗶𝗻𝗴 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁𝗹𝘆-𝗹𝗮𝗯𝗲𝗹𝗲𝗱 𝗺𝘆𝗼𝗳𝗶𝗯𝗲𝗿 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗲𝘀. This very elegant way to visualize the injury and track how the nucleus moves along the muscle fiber for the repair, lead to the discovery that the cell nucleus moves to the site of injury to deliver various repair factors. 𝗧𝗵𝗶𝘀 𝗳𝗶𝗻𝗱𝗶𝗻𝗴 𝗺𝗮𝘆 𝗵𝗮𝘃𝗲 𝗮 𝗯𝗶𝗴 𝗶𝗺𝗽𝗮𝗰𝘁 𝗼𝗻 𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗺𝘂𝘀𝗰𝗹𝗲 𝗿𝗲𝗽𝗮𝗶𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗶𝗻 𝗵𝗲𝗮𝗹𝘁𝗵 𝗮𝗻𝗱 𝗱𝗶𝘀𝗲𝗮𝘀𝗲. Read the paper for a deeper understanding of this groundbreaking discovery. https://lnkd.in/dRDEg3tq #musclerepair #invitro #diseaserecovery #health #stemcells (*) William Roman , Helena Pinheiro, Mafalda R. Pimentel, Jessica Segalés, Luis M. Oliveira, Esther García-Domínguez ,Mari Carmen Gómez-Cabrera , Antonio L. Serrano, Edgar Gomes , and Pura Munoz-Canovesñoz-Cánoves

𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝗼𝘂𝗿 𝗼𝗿𝗴𝗮𝗻-𝗼𝗻-𝗰𝗵𝗶𝗽 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺 𝗳𝗮𝗰𝗶𝗹𝗶𝘁𝗮𝘁𝗲 𝗼𝗿𝗴𝗮𝗻𝗼𝗶𝗱 𝗰𝘂𝗹𝘁𝘂𝗿𝗲? 🧫 The short answer is due to its 𝘃𝗲𝗿𝘀𝗮𝘁𝗶𝗹𝗶𝘁𝘆. But you probably want more detail😊 : - The open well design accommodates 𝗲𝗮𝘀𝘆 𝘀𝗮𝗺𝗽𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝗼𝗻-𝗱𝗲𝗺𝗮𝗻𝗱 𝗮𝗰𝗰𝗲𝘀𝘀 of your organoid - The optically transparent window allows for 𝗿𝗲𝗮𝗹 𝘁𝗶𝗺𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 - Perfusable fluidic channels ensures that your cultures receive a c𝗼𝗻𝘁𝗶𝗻𝘂𝗼𝘂𝘀 𝘀𝘂𝗽𝗽𝗹𝘆 𝗼𝗳 𝗲𝘀𝘀𝗲𝗻𝘁𝗶𝗮𝗹 𝗼𝘅𝘆𝗴𝗲𝗻 𝗮𝗻𝗱 𝗻𝘂𝘁𝗿𝗶𝗲𝗻𝘁𝘀, prolonging their viability - Microfluidic channels can also be lined with endothelial cells to𝗰𝗿𝗲𝗮𝘁𝗲 𝗮 𝟯𝗗 𝗯𝗹𝗼𝗼𝗱 𝘃𝗲𝘀𝘀𝗲𝗹 𝗰𝗼-𝗰𝘂𝗹𝘁𝘂𝗿𝗲 with your tissue type of interest Read more about the research at Erasmus MC, who used the Bi/ond comPLATE™ to vascularise their #iPSC-derived kidney organoids using non-host endothelial cells. Download the PDF to find out more #gobiond #organoids #ooc #vascularization #kidney #research #erasmusmc

We are continuing our #OoC Tips series with some wise advice from our Principal Scientist, Marieke Aarts. Ever wondered how to best tackle a transfer from a 2D to a 3D model? Do you have other ideas for scientists going through this process? Let us know in the comments! #gobiond #3dmodel #research #cellchoice

In an exciting collaboration, Bi/ond and Axol Bioscience Ltd. are pushing the boundaries of #cardiactissue engineering with the development of a robust, physiologically relevant 3D cardiac muscle model. Using Axol’s axoCells™ Ventricular Cardiomyocytes we have successfully established protocols to 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝗮𝗻𝗱 𝗰𝗵𝗮𝗿𝗮𝗰𝘁𝗲𝗿𝗶𝘇𝗲 𝗵𝘂𝗺𝗮𝗻 𝟯𝗗 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗺𝘂𝘀𝗰𝗹𝗲 𝘁𝗶𝘀𝘀𝘂𝗲𝘀 𝘁𝗵𝗮𝘁 𝗰𝗹𝗼𝘀𝗲𝗹𝘆 𝗺𝗶𝗿𝗿𝗼𝗿 𝗵𝘂𝗺𝗮𝗻 𝗵𝗲𝗮𝗿𝘁 𝘁𝗶𝘀𝘀𝘂𝗲, within Bi/ond's MUSbit™ platform. 𝗪𝗶𝘁𝗵𝗶𝗻 𝗷𝘂𝘀𝘁 𝟳 𝗱𝗮𝘆𝘀, 𝘄𝗲 𝗺𝗮𝗻𝗮𝗴𝗲𝗱 𝘁𝗼 𝗼𝗯𝘁𝗮𝗶𝗻 𝘀𝗽𝗼𝗻𝘁𝗮𝗻𝗲𝗼𝘂𝘀𝗹𝘆 𝗯𝗲𝗮𝘁𝗶𝗻𝗴 𝗵𝗲𝗮𝗿𝘁 𝘁𝗶𝘀𝘀𝘂𝗲! How did we do it? ❤️𝗠𝗶𝘅𝗶𝗻𝗴 𝘁𝗵𝗲 𝗮𝘅𝗼𝗖𝗲𝗹𝗹𝘀™ 𝗩𝗲𝗻𝘁𝗿𝗶𝗰𝘂𝗹𝗮𝗿 𝗖𝗮𝗿𝗱𝗶𝗼𝗺𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝘄𝗶𝘁𝗵 𝗽𝗿𝗶𝗺𝗮𝗿𝘆 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗳𝗶𝗯𝗿𝗼𝗯𝗹𝗮𝘀𝘁𝘀 at different ratios we were able to more closely mimic the native state of the heart ❤️The differentiation and maturation into functional ventricular cardiomyocytes were evaluated in a 𝟯𝗗 𝘀𝗲𝘁𝘁𝗶𝗻𝗴 ❤️We studied how the 𝗳𝗶𝗯𝗿𝗼𝗯𝗹𝗮𝘀𝘁𝘀 𝗮𝗳𝗳𝗲𝗰𝘁𝗲𝗱 𝘀𝗲𝗹𝗳-𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻, 𝗮𝗻𝗱 𝗺𝗮𝗶𝗻𝘁𝗲𝗻𝗮𝗻𝗰𝗲 of the 3D tissues ❤️Through Bi/ond’s MUSbit™ platform, we could also study the 𝘁𝗶𝘀𝘀𝘂𝗲𝘀’ 𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗶𝗹𝗲 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝗲𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝗽𝘂𝗹𝘀𝗲 𝘀𝘁𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻, a technique known as "pacing" ❤️We also analyzed the 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝘀𝗲𝘃𝗲𝗿𝗮𝗹 𝗰𝗮𝗿𝗱𝗶𝗼𝘁𝗿𝗼𝗽𝗶𝗰 𝗱𝗿𝘂𝗴𝘀, a crucial step in validating the model’s 𝘂𝘁𝗶𝗹𝗶𝘁𝘆 𝗳𝗼𝗿 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗮𝗻𝗱 𝘁𝗼𝘅𝗶𝗰𝗼𝗹𝗼𝗴𝘆 𝘀𝘁𝘂𝗱𝗶𝗲𝘀 The goal of this partnership is to provide an enhanced platform for cardiac research, enabling 𝗺𝗼𝗿𝗲 𝗮𝗰𝗰𝘂𝗿𝗮𝘁𝗲 𝘀𝘁𝘂𝗱𝗶𝗲𝘀 𝗼𝗳 𝗵𝗲𝗮𝗿𝘁 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗱𝗿𝘂𝗴 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀. This model brings us closer to 𝗿𝗲𝗮𝗹𝗶𝘀𝘁𝗶𝗰 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝗻𝗱 𝘀𝗮𝗳𝗲𝗿, 𝗺𝗼𝗿𝗲 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆. Watch our video to see the heart model in action! ❤️ #gobiond #ooc #cardiacmodel #heartbeat #heartcontraction #hearttissue #electricalstimulation #pacing #drugdiscovery #toxicology Read more about our products and applications : https://lnkd.in/e869vNd9