ApconiX

https://lnkd.in/eKUM83uq We are seeking an enthusiastic early career Data Scientist. This role offers an exciting opportunity to apply your data science skills to critical aspects of early drug discovery and development to support our target and drug modality safety offerings and will also include collaborating with other business areas including marketing and business development and our laboratory scientists. This role will sit within our Data Science Team and will be primarily located in Alderley Edge, Cheshire, UK but allows for some hybrid working. Qualifications: ·  Minimum of a Bachelor's or master’s degree in Data Science, Computer Science, Statistics, or a related field ·  Fluent English with excellent communication skills ·  Evidence of professional experience a bonus ·  The successful candidate must, by the start of the employment, have permission to work in the UK Character attributes: ·   Curiosity and eagerness to learn new skills and technologies ·   Excellent problem solving and critical thinking abilities ·   Ability to work independently and collaboratively to work on diverse projects across different business areas ·   Good time management skills to handle multiple tasks efficiently ·   Ethical awareness regarding data privacy and security Technical requirements: ·   Strong proficiency in programming languages such as R’ or Python for backend development and creation of automated processing pipelines ·   Ability to identify, wrangle and transform data in multiple formats for integration and interpretation ·   Create data visualisations and reports to communicate complex safety insights to project teams ·   Experience with using frameworks and creating databases (e.g., SQL, GraphQL, SPARK, MongoDB) ·   Experience with cloud computing platforms and big data (e.g., AWS, Google Cloud) for scalable deployment and API integration ·   Experience with natural language processing for literature mining a bonus How to Apply: Please submit a CV with a one page covering letter demonstrating how you meet the candidate requirements to careers@apconix.com by Friday 17th January. For more information, contact Nicholas James Coltman, PhD nicholas.coltman@apconix.com.  #drugdiscovery #drugsafety #careers

Excellent Christmas Do and as always lots of photos 😁 🎄 🎁 https://lnkd.in/eyS6gi4G Have a lovely holiday everyone and a Happy New Year to you too #drugsafety #drugdiscovery

Sophie Grice, Katy Saide, Liam Farrell, Georgia Wells, Catherine Betts, Sean Hammond, Dean J Naisbitt, Immune checkpoint blockade lowers the threshold of naïve T-cell priming to drug-associated antigens in a dose-dependent fashion, Toxicological Sciences, Volume 202, Issue 1, November 2024, Pages 13–18, https://lnkd.in/ekukrfzx Abstract: A growing body of clinical and experimental evidence indicates that immune checkpoint blockade enhances patient susceptibility to hypersensitivity reactions to co-administered medications. In this study, we utilized an in vitro T-cell priming assay to demonstrate one of the mechanistic hypotheses on how this occurs; through lowering of the threshold in patients to elicit aberrant T-cell responses. We outline the dependency of de novo T-cell priming responses to drug-associated antigens on dose at initial exposure. Findings support the aforementioned hypothesis and offer an experimental representation of fundamental parameters at play in hypersensitivity reactions to low molecular weight compounds #drugsafety #drugdiscovery

Beautiful singing from Emily Johnson, Joeley Hatch, Magali-Anne Maizières, Andrew Walker, Jess Ferguson, Ruth Roberts, Sophia Tomlinson and Hannah Jennings at Alderley Park 🎄 Christmas Market 🎄 yesterday in aid of Visyon If you didn't manage to donate and would still like to here is the link: https://lnkd.in/eaqdPRMC Many thanks 😊 #drugsafety #drugdiscovery

https://lnkd.in/eYpNqE9F The placement will involve training in cell culture, cell line generation, automated patch-clamp, micro-electrode array, and data analysis. There is also the opportunity to undertake a significant period of research. The ideal candidate will be enthusiastic about science and keen to learn. The position is salaried and will be based at Alderley Park in Cheshire (the UKs biggest life science campus). Applications by CV and covering email, please, to Dr Michael Morton. michael.morton@apconix.com. Closing date for this opportunity is the 31st of January 2025. Interviews will take place during February 2025. Previous placement students include Bethan Kelly: https://lnkd.in/eJVWNM5Y and Isabelle Heys: https://lnkd.in/eeP-gtd5. Our current placement student is Sophia Tomlinson (pictured). Bethan thoroughly enjoyed her time with us, adding, “This is the best thing I’ve ever done!” Alderley Park is in the heart of the beautiful Cheshire countryside, close to Manchester and its International Airport (10 miles). #careers #drugsafety #drugdiscovery

Last day of the American College of Toxicology Annual Meeting 2024. Simon Craige, Helen Garside, Ruth Roberts, Claire Sadler and Laurence Bishop thank everyone for making it a great meeting again this year. Looking forward to ACT2025. The winners of the Chestnut (cutest squirrel in town 😀) draws were Hilary Sheevers from Akkeri, Inc., Joske Millecam from CureVac and Rachel Goldsmith from Beam Therapeutics (pictured top). The winner of the whiskey draw was Haojing Rong, also pictured. Congratulations everyone 👏 #drugsafety #drugdiscovery #ACT2024

Don't forget this Thursday at 12:30, Philip Burridge from Morula Health will be presenting From Discovery to IND: The Critical Role of Medical Writing at Alderley Park https://lnkd.in/ewenVg2w Sponsored by Bruntwood, Gentronix, Part of Scantox Group and Redx Pharma #drugsafety #drugdiscovery

Kimberly Louise Rockley presented her poster at the American College of Toxicology. Seen here with Richard Knight. The poster "Benefits of early in vitro screening for seizure liability in problem solving and decision making" is co-authored by Ruth Roberts and Michael Morton. Click here https://lnkd.in/ekN7x3tf to find out more about our seizure liability assay ISLA or visit us on Booth 516 #drugsafety #drugdiscovery #ACT2024

Having just got back from Houston, Chestnut is off to Austin for the American College of Toxicology Annual Meeting. Two trips to Texas in the same month. Chestnuts are becoming one of our favourite exports 😀 Visit Booth 516 for a chance to take Chestnut (or a bottle of whiskey 😀 ) home. #drugsafety #drugdiscovery #ACT2024

Richard Knight, Ruth Roberts, Laurence Bishop, Helen Garside, Kimberly Rockley, Susan Tantawi, DABT, Peggy Guzzie-Peck, Claire Sadler, Jane Stewart, Simon Craige and Andrew Winkley will attending the American College of Toxicology Annual Meeting next week. Come a visit us at Booth 516. A busy conference for us this year. Ruth will be a Symposium Chair for Seizure Liability: New Approaches to Detection (S04) along with Simon Authier from Charles River Laboratories. Monday 18th at 2pm. Ruth will also be presenting An Integrated Approach for Early In Vitro Seizure Prediction Utilizing Human Derived Induced Pluripotent Stem Cells and Human Ion Channel Assays (S04-5) at that symposium at 4:10pm. Jane is presenting Developmental Toxicity Risk Assessment of Pharmaceuticals: Current Use of NHP’s and Alternatives (S11-2) at the Informing Risk of Infertility and Adverse Pregnancy Outcome: Are Nonhuman Primates Really Needed? Symposium (S11). Tuesday Nov 19th at 2pm. Ruth is also Symposium Chair for Targeted Protein Degrader Therapeutics: Opportunities and Challenges (S16) along with Sule Karaman, PhD, DABT from Novartis. Wednesday 20th at 9am. Kim is presenting a poster "Benefits of early in vitro screening for seizure liability in problem solving and decision making". Look forward to meeting old colleagues and new #drugsafety #drugdiscovery #ACT2024