BASE Facility

The BASE mRNA Facility builds #mRNA #vaccines and #therapies for Australian researchers. We offer end-to-end services; from initial #design, #manufacture, and #formulation of mRNA. We have a successful track record of making hundreds of mRNA vaccines and therapies for a wide range of #applications. We are a team of passionate #scientists with expertise in mRNA #biology, #vaccine and #drug development, #biomanufacture and #clinical research. The BASE mRNA Facility is a non-profit facility supported by The University of Queensland and Therapeutic Innovation Australia and it is located at Australian Institute for Bioengineering and Nanotechnology AIBN. Our Services: 🔹 mRNA Design 🔹 mRNA Production (100ug to >5mg scale) 🔹 mRNA Formulation We understand that every research project is unique, which is why we offer two distinct options: 1️⃣ #Off-the-shelf #reporter #mRNA - Featuring a diverse selection, including eGFP, luciferase, nanoluc, mCherry, CRISPR Cas9, and ovalbumin, to name a few. 2️⃣ #Custom #mRNA #Production - Tailored to your precise specifications, this encompassing service includes: ✓ Optimization of sequences of interest ✓ Sequence synthesis and cloning into our BASE mRNA vector (which includes T7 promoter, optimised UTRs and polyA) ✓ Template Amplification and Purification for in vitro transcription (IVT) process. ✓ IVT and purification yielding capped or uncapped mRNA, with the option of unmodified or modified nucleotides, such as N1-Methylpseudouridine or Methoxyuridine. ✓ Comprehensive mRNA analysis and detailed reporting. Our Standard mRNA Production #Amounts: ✓ Small Scale: ~80-100ug ✓ Large Scale: ~1mg, ~2mg, ~5mg ✓ For quantities exceeding 5mg, we are delighted to discuss your specific requirements. Embark on your research journey with us! To initiate the process, simply click the link below to complete our #enquiryform. We are eager to learn more about your research goals and collaborate on groundbreaking scientific endeavors, driven by our cutting-edge mRNA solutions. 👉 [Enquiry Form Link]: https://lnkd.in/eWpHDK2E If you prefer direct communication, feel free to reach us via #email at base@uq.edu.au. #BASEmRNA #mRNAresearch #ScienceAdvancements #ResearchSolutions #Biotechnology #Genetics #mRNA #CustommRNA #AustraliaResearch #ScientificBreakthroughs #Innovation #ScienceCommunity #ResearchGoals

🎄✨ Merry Christmas and a Happy New Year ✨🎄 The BASE Facility thanks all our partners, colleagues, Therapeutic Innovation Australia, Australian Institute for Bioengineering and Nanotechnology AIBN, The University of Queensland, our incredible scientists and stakeholders for an impactful 2024. We’re grateful for a year of collaboration and innovation, and we look forward to bringing more #mRNA breakthroughs in the new year. Wishing everyone a joyful holiday season! - From the BASE team -

We are #hiring! We are seeking a motivated Scientific Sales Manager to join the BASE Facility and help drive the adoption of #mRNA technologies. This role offers an excellent opportunity to establish sales and business development operations to support mRNA research.

If you missed Seth's TEDxUQ talk on personalised mRNA cancer vaccine, you can now watch it on YouTube! Ideas Worth Spreading!💡 #mRNA #Personalised #CancerVaccine

BASE end of year celebration 🎄 As we approach the end of 2024, the BASE team took some time to celebrate the progress we’ve achieved this year. From a delicious team lunch to an epic round of laser tag! 💥🔫 it was a fantastic way to bond, recharge, and have fun. A huge shoutout to our amazing team—your hard work and dedication make all the difference. We look forward to 2025! #TeamWork #WeLOVEmRNA #EOYcelebration

mRNA design software 🌟 We are excited to introduce #mRNArchitect - a software toolkit for designing and optimising mRNA sequences. https://lnkd.in/gbxZmjZy   This freely available software enables users to generate mRNA candidates optimised for expression, stability, and immunogenicity. Simply input your coding sequence of interest, and mRNArchitect will provide multiple candidate mRNA sequences, each accompanied by comprehensive statistics for evaluation.   At BASE, we have successfully used mRNArchitect to design hundreds of mRNAs for diverse applications, including vaccines, gene therapies, and cell therapies. We are now making this powerful toolkit freely available to scientists for the development of mRNA medicines. 🧬   The webpage includes helpful resources, such as tutorials and case studies, to guide you in using mRNArchitect for mRNA design. If you have any questions or ideas, please don’t hesitate to reach out to our design team at basedesign@uq.edu.au. Learn more here (BioRxiv): https://lnkd.in/gHReXCPw #mRNArchitect #mRNAdesign #software #mRNA

BASE Facility is #hiring! We're looking for an mRNA Production Scientist, a Software Developer, and a Bioinformatician. Join our mRNA Production and mRNA Design teams and be part of the vibrant mRNA space 🧬

We are further expanding and hiring! We currently have 3️⃣ positions available at BASE across our #mRNA production and mRNA design teams. 👇 mRNA Production Team: 🌟 mRNA production scientist (https://lnkd.in/gaVMxV-N) mRNA Design Team: 🌟 Software Developer (https://lnkd.in/gd8RFVUa): 🌟 Bioinformatician (https://lnkd.in/grDJ9JVv) If you have a passion for mRNA production and design, we look forward to hearing from you!

Tune into Episode 4 of VAXXED! BASE Deputy Director Dr Seth Cheetham was interviewed by Rachel Williamson about our #mRNA manufacturing services and the mRNA Cancer Vaccine Centre at the Australian Institute for Bioengineering and Nanotechnology AIBN, The University of Queensland. ▶ https://lnkd.in/gQanfJxQ

There is more to building an mRNA cancer vaccine than just making one work outside the lab. You've also got to be able to make them and be able to do so quickly, perhaps using an individual patient's own biological material depending on the therapeutic.   Dr Seth Cheetham from the The University of Queensland's BASE Facility mRNA manufacturing hub is heading up the effort to make mRNA for research and clinical trial use. But they are going deep on cancer - why? Because the data is showing that this time, the investment is worth it. Tune in to episode 4 of VAXXED on Wednesday. Like all independent media, we survive and thrive on your support. So please – listen, follow, engage, and if you can, donate ❤️ >> Listen https://bit.ly/4fzc32a >> Watch Phase III on YouTube https://lnkd.in/gWs57mzy >> Follow Phase III on LinkedIn and subscribe to our email newsletter https://bit.ly/3WUBgwZ >> Donate (via the ‘Support’ button) and/or subscribe to Phase III https://bit.ly/4cnfwhO #biotech #vaccine #health #cancer #podcast #media #australia