Beitrag von MiBioLab (Microbial Bioprocess Lab)

#postdoc #postdocposition Postdoctoral researcher at the Smart Nano-Bio-Devices Research Group Requirements for candidates: PhD in the field of pharmacy, chemistry, biotechnology, nanomedicine, biochemistry, or similar. Experience in nanoparticle synthesis and functionalization of biocompatible and biodegradable inorganic and organic nanocarriers. Experience in drug loading and drug delivery studies with therapeutic small molecules. Knowledge on common characterization techniques (NMR, FTIR, DLS, Z-potential, GPC, HPLC chromatography, SEM, TEM, AFM, spectroscopy equipments, etc) Experience in cell culture and biological assays (viability and metabolic studies, immunostaining and confocal microscopy, RT-PCR and WesternBlot) High level of English. Communication, Teamwork, Proactivity, Commitment, Collegiality, Integrity, Critical and Analytical thinking. https://lnkd.in/dKfTHEhy

Suchst Du eine spannende Stelle als Doktorand:in in der Mikrobiologie/Biochemie? Gemeinsame mit Prof Dieter Jahn von der Technische Universität Braunschweig suche ich eine:n begeisterte:n Forscher:in für das Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH-Labor am BRICS zu molekularen Anpassungsstragien von Pathogen: https://lnkd.in/ehJi_Gjb #BRICS #PhDposition

This is mind-blowing! Revolutionary Breakthrough in Synthetic Biology! 🧬 💫 Scientists at the University of Basel have taken a giant leap in synthetic biology by creating synthetic cells that can communicate with each other using light signals. This groundbreaking discovery opens up new possibilities for advanced therapies, enabling communication networks between synthetic and natural cells and paving the way for synthetic tissue development. The idea of creating synthetic cells that can communicate with each other, and potentially with our own cells, opens up a world of possibilities. We can't wait to see how this technology will revolutionize medicine and other fields! 🔗 Read the full article here: https://lnkd.in/dSw2JJbW #syntheticbiology #biotechnology #science #innovation #futureofmedicine #scienceinnovation #sciencediscoveries #cells #scienceresearch

Was ich heute zum Thema #Technologie und #Innovation lese. Ein Beitrag von #: Universitätsprofessur (W3) "Lebensmittelchemie und Toxikologie" - Academics Bestimmt relevant für einige Kollegen bei #Schattdecor und #MyMineralMix !

Nach dem Info-Anlass ist vor dem Info-Anlass! Hast du den letzten Info-Anlass zum Bachelor in Life Sciences verpasst? Am 15. April hast du nochmals die Gelegenheit, mehr über unsere acht Studienrichtungen zu erfahren, den FHNW Campus Muttenz und unsere Labore zu besichtigen und dich mit Studiengangleitenden, Dozierenden und Studierenden auszutauschen. Melde dich jetzt an 👇 #lifesciencesfhnw #fhnwcampusmuttenz #bachelor #bachelorstudium #bachelorinlifesciences #bioanalytik #zellbiologie #biotechnologie #chemie #chemicalengineering #medizininformatik #medizintechnik #pharmatechnologie #umwelttechnologie

#Industrial #PhD #student #position available in #Lund, #Sweden We are looking for outstanding graduates from all over the world and are delighted to provide them with the best possible conditions for their scientific careers. The graduate program Lund University at faculty of medicine provides an interdisciplinary education for doctoral candidates at the interface of #molecular #life #sciences and #clinical #science. In addition, the candidate will be employed and strongly connected to the scientific activities at a small biotech company Apoglyx AB. If you have a passion for #structural #biology, molecular biology, cell biology, protein biochemistry and drug discovery and want to work in an interdisciplinary setting at Lund University at faculty of medicine- this is the doctoral program for you! Application: Please prepare your CV and motivation letter, your academic record and the name of two referees willing to provide references, then apply by the 1st of January 2025 by email to: Prof. Karin Lindkvist (karin.lindkvist@med.lu.se) Short summary of the project with a few references from Lindkvist laboratory. Maintaining a balance between activation and suppression of immune response is critical for the immune system. Systemic Inflammatory Response Syndrome (SIRS) is an exaggerated response of the immune system and is a potentially life-threatening medical condition that is characterized by a self-harming immune response. SIRS can be initiated by an infection (then called sepsis), or by sterile causes of cell damage, such as trauma. A hallmark of both sepsis and SIRS is the massive recruitment neutrophils from the bone marrow into the circulation. Together with academic collaborators, ApoGlyx AB has demonstrated that genetic ablation of AQP9 is an effective way for interfering with SIRS, by preventing tissue infiltration of neutrophils. Based on these promising results, the aim is to decipher the structural-functional activity of AQP9 and develop a series of compounds blocking its activity. The 3D structure of AQP9 will be determined with and without inhibitors by single particle cryo-EM to augment structure-based drug design. Molecular basis for human aquaporin inhibition. Huang P, Åbacka H, Wilson CJ, Wind ML, Rützler M, Hagström-Andersson A, Gourdon P, de Groot BL, Venskutonytė R, Lindkvist-Petersson K. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2319682121. SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia Åbacka H, Masoni S, Poli G, Huang P, Gusso F, Granchi C, Minutolo F, Tuccinardi T, Hagström-Andersson AK, Lindkvist-Petersson K. Sci Rep. 2024 Apr 20;14(1):9104. Cryo-EM structure supports a role of AQP7 as a junction protein. Huang P, Venskutonytė R Prasad RB, Ardalani H, de Maré SW, Fan X, Li P, Spégel P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K. Nature Commun. 2023 Feb 3;14(1):600.

The advancement of the highly multidisciplinary field of lipid nanoparticle (LNP) research hinges largely on detailed scientific discussions. For this reason, I highly appreciate article formats that facilitate scientific discussions. In a recent Matters Arising article, I discuss some technical aspects related to a very interesting study on the biomolecular corona on LNPs. Notably, the study revealed that rats’ individual health state (obese vs. lean) significantly impacts the composition of the biomolecular corona, and consequently, the transfection potency of LNPs. Perhaps we should consider using disease-specific plasma/serum sources for in vitro LNP studies, if possible, and when relevant - especially in cases where significant alterations in the lipoprotein profile are expected. The comprehensive study presents many interesting findings, but as with many multidisciplinary-based research articles, it may be associated with some unintended limitations. In my Matters Arising article, I highlight potential technical challenges associated with this study. The beauty of this article format lies in its allowance for authors of the original article to respond to the concerns raised, fostering a rich and detailed scientific discussion. If you want to learn more about this article format and potential technical challenges related to the isolation of LNPs from plasma (or serum), you should take a look at this one: https://lnkd.in/dBRDj2Hi Best, Jens (Independent Scientific Consultant seeking temporary assignments or permanent positions)

#hiring Research Associate: UMass Chan Medical School The post-doctoral scholar will lead a project focusing on understanding the complex interactions between the effector proteins of the Shigella bacteria and the host cell proteins related to the phagocytosis vacuole. This study will use in vitro models of epithelial cell cultures infected with bacteria, bacterial extracts, or purified compounds. Using chemical bridging methods to stabilize the formed complexes, the scholar will employ mass spectrometry to analyze and identify the components involved. Additionally, the post-doc will explore the impacts of these interactions on the intracellular replication of bacteria using fluorescence microscopy. This in-depth examination will offer valuable insights into the mechanisms governing the survival and growth of Shigella bacteria within host cells. By illuminating the molecular interactions at play, this research aims to enhance understanding of bacterial pathogenesis and potentially open avenues for new therapeutic approaches to combat bacterial infections.