OMAPiX

We are excited to welcome OMAPiX to our Certified Service Provider (CSP) Program. “The launch of our Certified Service Provider Program is a key step in enabling more researchers to have access to our single-cell multiomic technology without establishing the protocols in their own laboratories. With OMAPiX now a member of our CSP program, researchers now have another trusted partner for their single-cell multiomics projects," said Don Trapolsi, AVP of Genomic Services at BioSkryb Genomics. For more details on our CSP Program and partners announced to date, visit https://lnkd.in/gbjCA2N3 For more details on OMAPiX's offerings, visit https://omapix.com/

We are excited to welcome OMAPiX to our Certified Service Provider (CSP) Program. “The launch of our Certified Service Provider Program is a key step in enabling more researchers to have access to our single-cell multiomic technology without establishing the protocols in their own laboratories. With OMAPiX now a member of our CSP program, researchers now have another trusted partner for their single-cell multiomics projects," said Don Trapolsi, AVP of Genomic Services at BioSkryb Genomics. For more details on our CSP Program and partners announced to date, visit https://lnkd.in/gbjCA2N3 For more details on OMAPiX's offerings, visit https://omapix.com/

Great to see our scTrends review of commercial single-cell and spatial solutions out in Cell Genomics today, massive thank you to Jake P. Taylor-King Adam Cribbs James Opzoomer, Amaia, Benedikt and everyone else from the consortium for turning this into such an insightful piece, link: https://lnkd.in/g-a_UnP7

This project has been a dream come true. We are proud to present the first comprehensive atlas of the adult oral cavity, created using cutting-edge single-cell and spatial multiomic technologies, “The Immunoregulatory Architecture of the Adult Oral Cavity.” This foundational work provides an in-depth exploration of healthy mucosal and glandular tissues, offering key insights into structural immunity, its role in tissue homeostasis, and its potential as a therapeutic target in disease. Link: https://lnkd.in/etpRka-u Key takeaways: 1. Integrated analysis of >250,000 single cells from 70 healthy human oral tissue samples, spanning 13 niches, including salivary glands, mucosae, and pulp. 2. Spatial proteomics (CODEX/Phenocycler2.0) and transcriptomics (MERSCOPE) atlases, comprised of >2 million cells and through integrated, deep learning analysis, identifying 8 Tissue Cellular Neighborhoods (TCNs) and 17 Multicellular Interaction Modules (like neighborhoods for cell-cell communication; MCIMs) in gland and mucosae 3. We introduce AstroSuite, our advanced AI-assisted bioinformatics toolkit. This suite has transformed workflows with tools like TACIT, Constellation, and STARComm, enabling scalable spatial analysis, interactive visualization, and spatial receptor-ligand exploration. This atlas is part of the Human Cell Atlas initiative led by the Oral & Craniofacial Bionetwork and paving the way for next versions focusing on disease states like chronic inflammation and cancer. Future plans also include integrating findings into a comprehensive pan-airway spatial multiomics. We believe this is just the beginning of a transformative journey in oral and systemic health research. This would not have been possible without generous time, talent, and effort of lead authors Bruno Matuck, Khoa Huynh, and Diana Pereira and senior authors Ines Sequeira, Jinze Liu (Virginia Commonwealth University and Queen Mary University of London). More than that leadership team, however, was an incredible team of scientists XiuYu Zhang, Meik Kunz, Quinn Easter, Alexandre Fernandes, Alex Predeus, Paola Perez Riveros Ph.D., Adam Kimple, Sarah Pringle, Blake M. Warner, DDS, PhD, MPH, DABOMP, and many others across American Dental Association, OMAPiX, University of North Carolina at Chapel Hill, @Mildred-Scheel Early Career Centre for Cancer Research, The National Institutes of Health, University of Pennsylvania, University of Groningen. As always, we are grateful to Sarah Teichmann FMedSci FRS for her support, creativity, and guidance. Finally, collaborations with 10x Genomics, Vizgen, Akoya Biosciences, Inc. has made this possible; we remakn grateful for the trust and opportunity. Join us in celebrating this milestone, and stay tuned for updates as we expand this into diseased tissue contexts and therapeutic applications. #OralBiology #SpatialBiology #HumanCellAtlas #AstroSuite #PrecisionMedicine #CellCommunication