Core Biogenesis

𝙃𝙤𝙬 𝙩𝙤 𝙢𝙖𝙞𝙣𝙩𝙖𝙞𝙣 𝙨𝙩𝙚𝙢 𝙘𝙚𝙡𝙡 𝙘𝙪𝙡𝙩𝙪𝙧𝙚𝙨 𝙢𝙤𝙧𝙚 𝙚𝙛𝙛𝙞𝙘𝙞𝙚𝙣𝙩𝙡𝙮 𝙖𝙣𝙙 𝙝𝙤𝙢𝙤𝙜𝙚𝙣𝙚𝙤𝙪𝙨𝙡𝙮? #Stemcell maintenance requires the proper activation of FGF signalling, as the growth factor FGF-2 is involved in a variety of biological processes, including embryonic development, neural differentiation, and the proliferation of cells of mesodermal origin 🧬 👉 Therefore, the addition of exogenous FGF-2 is required to sustain stem cell self-renewal, and their capacity to differentiate into a large number of somatic cell types. Still, the application of commonly commercialized FGF-2 is limited due to its rapid loss during cultivation, as extensive research studies have shown FGF-2 to be unstable at physiological conditions, with a half-life of approximately 8 h in mammalian cell culture 🧫 As such, the need for a FGF-2 product with excellent stability is essential -specially as the field of stem cell research and manufacturing continues moving towards serum-free / chemically defined cell culture media conditions 🧪 Core Biogenesis is pleased to provide one of the most advanced options in the market to integrate a highly stable FGF-2 molecule to achieve #consistency during #StemCellCultures. Our star product 𝗙𝗚𝗙-𝟮 𝗧𝗢𝗣® (𝗧𝗵𝗲𝗿𝗺𝗼𝘀𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗲𝗱), is available to satisfy all the demands and needs from the research to the clinical manufacturing stages, now being also developed in #GMPgrade in collaboration with our partner, Nucleus Biologics. ⏩ Scroll to have a glimpse of the amazing attributes and performance of FGF-2 TOP® (𝘛𝘩𝘦𝘳𝘮𝘰𝘴𝘵𝘢𝘣𝘪𝘭𝘪𝘵𝘺 𝘖𝘱𝘵𝘪𝘮𝘪𝘻𝘦𝘥) 𝚈𝚘𝚞 𝚌𝚊𝚗 𝚕𝚎𝚝 𝚞𝚜 𝚔𝚗𝚘𝚠 𝚢𝚘𝚞𝚛 𝚒𝚗𝚝𝚎𝚛𝚎𝚜𝚝 𝚏𝚘𝚛 𝚎𝚟𝚊𝚕𝚞𝚊𝚝𝚒𝚘𝚗 𝚊𝚝 𝚢𝚘𝚞𝚛 𝚍𝚎𝚜𝚒𝚛𝚎𝚍 𝚐𝚛𝚊𝚍𝚎 𝚋𝚢 𝚌𝚘𝚗𝚝𝚊𝚌𝚝 𝚞𝚜 𝚑𝚎𝚛𝚎: https://lnkd.in/eXTG3S8h #StemCells #Research #CellTherapy #GrowthFactors #SustainableSciene

𝙃𝙤𝙬 𝙩𝙤 𝙢𝙖𝙞𝙣𝙩𝙖𝙞𝙣 𝙨𝙩𝙚𝙢 𝙘𝙚𝙡𝙡 𝙘𝙪𝙡𝙩𝙪𝙧𝙚𝙨 𝙢𝙤𝙧𝙚 𝙚𝙛𝙛𝙞𝙘𝙞𝙚𝙣𝙩𝙡𝙮 𝙖𝙣𝙙 𝙝𝙤𝙢𝙤𝙜𝙚𝙣𝙚𝙤𝙪𝙨𝙡𝙮? #Stemcell maintenance requires the proper activation of FGF signalling, as the growth factor FGF-2 is involved in a variety of biological processes, including embryonic development, neural differentiation, and the proliferation of cells of mesodermal origin 🧬 👉 Therefore, the addition of exogenous FGF-2 is required to sustain stem cell self-renewal, and their capacity to differentiate into a large number of somatic cell types. Still, the application of commonly commercialized FGF-2 is limited due to its rapid loss during cultivation, as extensive research studies have shown FGF-2 to be unstable at physiological conditions, with a half-life of approximately 8 h in mammalian cell culture 🧫 As such, the need for a FGF-2 product with excellent stability is essential -specially as the field of stem cell research and manufacturing continues moving towards serum-free / chemically defined cell culture media conditions 🧪 Core Biogenesis is pleased to provide one of the most advanced options in the market to integrate a highly stable FGF-2 molecule to achieve #consistency during #StemCellCultures. Our star product 𝗙𝗚𝗙-𝟮 𝗧𝗢𝗣® (𝗧𝗵𝗲𝗿𝗺𝗼𝘀𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗲𝗱), is available to satisfy all the demands and needs from the research to the clinical manufacturing stages, now being also developed in #GMPgrade in collaboration with our partner, Nucleus Biologics. ⏩ Scroll to have a glimpse of the amazing attributes and performance of FGF-2 TOP® (𝘛𝘩𝘦𝘳𝘮𝘰𝘴𝘵𝘢𝘣𝘪𝘭𝘪𝘵𝘺 𝘖𝘱𝘵𝘪𝘮𝘪𝘻𝘦𝘥) 𝚈𝚘𝚞 𝚌𝚊𝚗 𝚕𝚎𝚝 𝚞𝚜 𝚔𝚗𝚘𝚠 𝚢𝚘𝚞𝚛 𝚒𝚗𝚝𝚎𝚛𝚎𝚜𝚝 𝚏𝚘𝚛 𝚎𝚟𝚊𝚕𝚞𝚊𝚝𝚒𝚘𝚗 𝚊𝚝 𝚢𝚘𝚞𝚛 𝚍𝚎𝚜𝚒𝚛𝚎𝚍 𝚐𝚛𝚊𝚍𝚎 𝚋𝚢 𝚌𝚘𝚗𝚝𝚊𝚌𝚝 𝚞𝚜 𝚑𝚎𝚛𝚎: https://lnkd.in/eXTG3S8h #StemCells #Research #CellTherapy #GrowthFactors #SustainableSciene

🗣️ Peer stem cell scientists 🥼 Your work from #stemcell research to #celltherapy development is changing the world of human biology and medicine 🔬 To uncover all the potential of your stem cell cultures, your 𝒊𝒏 𝒗𝒊𝒕𝒓𝒐 experiments need to be representative of the 𝒊𝒏 𝒗𝒊𝒗𝒐 effects. As such, you deserve the technologies and tools that bring you a perfect balance between accurate cell signalling, and optimized cell culture conditions 🧫 ⚡️ This is FGF-2 TOP®, the thermostable version of FGF-2 (bFGF) that enables to get your desired cell response at all times: https://lnkd.in/eWz3-qHW ➡ To keep 100% of pluripotency ➡ To improve stem cell expansion into large culture vessels ➡ To ensure consistent phenotypes during your differentiation workflows 🏅 In sum, a TOP performing growth factor for your high quality stem cell cultures. After collaborating with hundreds of scientist around the world 🌍 to optimize their culture protocols, this thermostable FGF-2 is now also developed in GMP grade, in collaboration with our partner, Nucleus Biologics. Want to use it? We have 2 special offers for you 🙌 Ｆｏｒ ｔｈｅ ＲＵＯ Ｇｒａｄｅ: Core Biogenesis will duplicate the amount you get (available for both formats 50µg and 1mg): If you get 50µg, we provide 100µg; If you get 1mg, we provide 2mg; If you get 50mg, we provide 100mg! Ｆｏｒ ｔｈｅ ＧＭＰ Ｇｒａｄｅ: you can get first access here: https://lnkd.in/eXTG3S8h Only until the end of the year! To submit your interest, request a quote or product quantity, our team will help you at: customers@corebiogenesis.com 💚 #StemCellResearch #CellTherapy

✨ So excited to be presenting at the upcoming Society of Cosmetic Chemists HQ annual meeting in December! In a session moderated by the amazing Krupa Koestline, I will be presenting a talk on using Plants as Biofactories for next-generation proteins and peptides for the Cosmetic industry 🔬 Thank you Peyton K. and the rest of the SCC team for having me #SCC78 #cosmeticchemists #biotechbeauty #skincareinnovation 🌱 Core Biogenesis | Alexandre Reeber | Chouaib MEZIADI

Cost-Effective & Ultra-Scalable FGF-2 TOP® to Unlock the Potential of iPSC Research - https://lnkd.in/g997x_vn Reduce cost, save time, and simplify scale-up while optimizing your stem cell culture conditions with FGF-2 TOP® GMP, a high-performing, thermostabilized, plant-based recombinant protein. Nucleus Biologics FGF-2 TOP® GMP protein is derived from a proprietary, plant-based production process that ensures high purity and sustainability, while our unique bioproduction process delivers significant cost savings. Additionally, by eliminating the need for repeated supplementation and daily medium changes, expenses can be further reduced and convenience enhanced, streamlining workflows for greater efficiency. With its ultra-scalable manufacturing method and ability for proteins to be stored as seeds, supply chain bottlenecks are eliminated, ensuring a reliable source of GMP-grade proteins. Explore FGF-2 TOP® GMP today! #ipscell #stemcells #research David De Leonardis Brad Taylor David Sheehan

🌟 Celebrating a Decade of Innovation at the The International Scientific Conference on Cultured Meat (ISCCM) 🍔 This year marks the 10th anniversary of the #ISCCM —and the event was truly epic! All the topics covered during the sessions were the perfect blend to bring the flavor of the current state of the industry 💡😋 Some of the key messages served: 🥣 As cell processes in #cellularagriculture continue to be optimized… Ellen Parker explained how improving biomass yields at small scale bioreactors first, to then automate, make continuous production and transfer the technology into large scale, is the best path to success. 🥣 During the integration of advanced #bioprocessing technologies… Sissel Beate Rønning shared a perfect example of how this allows to get in-line controls of critical components and metabolites during production. 🥣 From studies on materials and media development for cultivated meat… Anirvan Guha explained how automation and their Bayesian-based optimisation process revealed the top-performing formulations for cell line production. Michael Saad also showed how the source of vital ingredients such as FGF-2 has a strong impact on cell proliferation - highlighting that species-matched proteins are not always the most effective! The last day left us truly inspired from the emotional bites of the tasting experiences shared by Ira van Eelen, and encouraged to contribute on lowering the environmental impacts of #cultivatedmeat from the lessons shared by Hanna Tuomisto. Cheers to the next decade of innovation, collaboration, and impact! 🙌 #ISCCM10 #CULTIVATEDMEAT #FOODFORALL #SUSTAINABILITY

🚀 Unlocking the Potential of PSC-derived therapies with Thermostable FGF-2 TOP® in cGMP Grade 🧫 💡 Why FGF-2 TOP® (Thermostability Optimized)? This groundbreaking recombinant protein is redefining #pluripotentstemcell culture by combining exceptional performance with cost efficiency. Developed by Core Biogenesis in collaboration with Nucleus Biologics to meet GMP-compliant quality attributes, this product brings several Key Benefits: ✔️ Supports Pluripotency: Maintains high-quality iPSC cultures with robust expression of pluripotency markers, even under various media feeding regimes and concentrations. ✔️ Enables Cost Reduction: Achieve equivalent results with every-other-day (EOD) feeding compared to daily supplementation with traditional FGF-2, reducing media costs without compromising quality. ✔️ Scales with Ease: Its thermostable nature ensures stability and consistency, making it ideal for large-scale manufacturing processes. ✔️ GMP Integration: Start integrating GMP-grade materials early in discovery and manufacturing to streamline the pathway toward cell therapies. 🫴 Explore the benefits of FGF-2 TOP® in your cell manufacturing process requesting your product offer here: https://lnkd.in/eXTG3S8h #celltherapy #pluripotentstemcells #rawmaterials #costreduction #patientaccess

🚀 Unlocking the Potential of PSC-derived therapies with Thermostable FGF-2 TOP® in cGMP Grade 🧫 💡 Why FGF-2 TOP® (Thermostability Optimized)? This groundbreaking recombinant protein is redefining #pluripotentstemcell culture by combining exceptional performance with cost efficiency. Developed by Core Biogenesis in collaboration with Nucleus Biologics to meet GMP-compliant quality attributes, this product brings several Key Benefits: ✔️ Supports Pluripotency: Maintains high-quality iPSC cultures with robust expression of pluripotency markers, even under various media feeding regimes and concentrations. ✔️ Enables Cost Reduction: Achieve equivalent results with every-other-day (EOD) feeding compared to daily supplementation with traditional FGF-2, reducing media costs without compromising quality. ✔️ Scales with Ease: Its thermostable nature ensures stability and consistency, making it ideal for large-scale manufacturing processes. ✔️ GMP Integration: Start integrating GMP-grade materials early in discovery and manufacturing to streamline the pathway toward cell therapies. 🫴 Explore the benefits of FGF-2 TOP® in your cell manufacturing process requesting your product offer here: https://lnkd.in/eXTG3S8h #celltherapy #pluripotentstemcells #rawmaterials #costreduction #patientaccess

🌟 Unlocking the Potential of iPSC Culture with FGF-2 TOP 🌟 💡 Why FGF-2 TOP? This innovative protein maintains high-quality #iPSC cultures, supporting #pluripotency and stemness across various concentrations and media feeding regimes. Recent data from Core Biogenesis and TreeFrog Therapeutics demonstrates its effectiveness: ✔️Flow cytometry data shows high expression of pluripotency markers under both 50 and 100 ng/mL FGF-2 TOP, in daily and every-other-day (EOD) feeding schedules. ✔️Impressively, EOD feeding with FGF-2 TOP achieves equivalent results to daily supplementation with traditional FGF-2, underscoring FGF-2 TOP's superior bioactivity and stability. Explore the full whitepaper for an in-depth look at how FGF-2 TOP can drive consistency in your iPSC cultures. https://hubs.ly/Q02X_6KG0 #StemCellResearch #iPSCCulture #BiotechInnovation #FGF2TOP #RegenerativeMedicine #celltherapy #cellandgenetherapy

Congratulations to all the team at Nucleus Biologics 👏 We couldn´t ask for a better partnership to deliver this game changer solution for #celltherapy with FGF-2 TOP® GMP 🌟 Our shared vision for promoting #sustainability in the field, while providing manufacturers with the flexibility and robustness for developing high-performance media formulations, already started to help building the future of #LifeSavingMedicines 💚 💙