Blaise Aguera y Arcas
Blaise leads Cerebra, a Google Research organization working on both basic research and new products. Among the team’s public contributions are MobileNets, Federated Learning, Coral, and many Android and Pixel AI features; they also founded the Artists and Machine Intelligence program. Until 2014 Blaise was a Distinguished Engineer at Microsoft, where he worked in a variety of roles, from inventor to strategist, and led teams with strengths in experience design, prototyping, machine vision, augmented reality, wearable computing and mapping. Blaise has given TED talks on Seadragon and Photosynth (2007, 2012), Bing Maps (2010), and machine creativity (2016). In 2008, he was awarded MIT’s TR35 prize.
Authored Publications
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Towards Generalist Biomedical AI
Danny Driess
Andrew Carroll
Chuck Lau
Ryutaro Tanno
Ira Ktena
Anil Palepu
Basil Mustafa
Aakanksha Chowdhery
Simon Kornblith
Philip Mansfield
Sushant Prakash
Renee Wong
Sunny Virmani
Sara Mahdavi
Bradley Green
Ewa Dominowska
Joelle Barral
Karan Singhal
Pete Florence
NEJM AI (2024)
Preview abstract
BACKGROUND: Medicine is inherently multimodal, requiring the simultaneous interpretation and integration of insights between many data modalities spanning text, imaging, genomics, and more. Generalist biomedical artificial intelligence systems that flexibly encode, integrate, and interpret these data might better enable impactful applications ranging from scientific discovery to care delivery.
METHODS: To catalyze development of these models, we curated MultiMedBench, a new multimodal biomedical benchmark. MultiMedBench encompasses 14 diverse tasks, such as medical question answering, mammography and dermatology image interpretation, radiology report generation and summarization, and genomic variant calling. We then introduced Med-PaLM Multimodal (Med-PaLM M), our proof of concept for a generalist biomedical AI system that flexibly encodes and interprets biomedical data including clinical language, imaging, and genomics with the same set of model weights. To further probe the capabilities and limitations of Med-PaLM M, we conducted a radiologist evaluation of model-generated (and human) chest x-ray reports.
RESULTS: We observed encouraging performance across model scales. Med-PaLM M reached performance competitive with or exceeding the state of the art on all MultiMedBench tasks, often surpassing specialist models by a wide margin. In a side-by-side ranking on 246 retrospective chest x-rays, clinicians expressed a pairwise preference for Med-PaLM Multimodal reports over those produced by radiologists in up to 40.50% of cases, suggesting potential clinical utility.
CONCLUSIONS: Although considerable work is needed to validate these models in real-world cases and understand if cross-modality generalization is possible, our results represent a milestone toward the development of generalist biomedical artificial intelligence systems.
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Large Language Models Encode Clinical Knowledge
Karan Singhal
Sara Mahdavi
Jason Wei
Hyung Won Chung
Nathan Scales
Ajay Tanwani
Heather Cole-Lewis
Perry Payne
Martin Seneviratne
Paul Gamble
Christopher Kelly
Abubakr Abdelrazig Hassan Babiker
Nathanael Schaerli
Aakanksha Chowdhery
Philip Mansfield
Dina Demner-Fushman
Katherine Chou
Juraj Gottweis
Nenad Tomašev
Alvin Rajkomar
Joelle Barral
Nature (2023)
Preview abstract
Large language models (LLMs) have demonstrated impressive capabilities, but the bar for clinical applications is high. Attempts to assess the clinical knowledge of models typically rely on automated evaluations based on limited benchmarks. Here, to address these limitations, we present MultiMedQA, a benchmark combining six existing medical question answering datasets spanning professional medicine, research and consumer queries and a new dataset of medical questions searched online, HealthSearchQA. We propose a human evaluation framework for model answers along multiple axes including factuality, comprehension, reasoning, possible harm and bias. In addition, we evaluate Pathways Language Model (PaLM, a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA, MedMCQA, PubMedQA and Measuring Massive Multitask Language Understanding (MMLU) clinical topics), including 67.6% accuracy on MedQA (US Medical Licensing Exam-style questions), surpassing the prior state of the art by more than 17%. However, human evaluation reveals key gaps. To resolve this, we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, knowledge recall and reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal limitations of today’s models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLMs for clinical applications.
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Towards Physician-Level Medical Question Answering with Large Language Models
Karan Singhal
Juro Gottweis
Le Hou
Kevin Clark
Heather Cole-Lewis
Amy Wang
Sami Lachgar
Philip Mansfield
Sushant Prakash
Bradley Green
Ewa Dominowska
Nenad Tomašev
Renee Wong
Sara Mahdavi
Joelle Barral
Arxiv (2023) (to appear)
Preview abstract
Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge.
Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach.
Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets.
We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations.
While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.
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LaMDA: Language Models for Dialog Applications
Aaron Daniel Cohen
Alena Butryna
Alicia Jin
Apoorv Kulshreshtha
Ben Zevenbergen
Chung-ching Chang
Cosmo Du
Daniel De Freitas Adiwardana
Dehao Chen
Dmitry (Dima) Lepikhin
Erin Hoffman-John
Igor Krivokon
James Qin
Jamie Hall
Joe Fenton
Johnny Soraker
Kathy Meier-Hellstern
Maarten Paul Bosma
Marc Joseph Pickett
Marcelo Amorim Menegali
Marian Croak
Maxim Krikun
Noam Shazeer
Rachel Bernstein
Ravi Rajakumar
Ray Kurzweil
Romal Thoppilan
Steven Zheng
Taylor Bos
Toju Duke
Tulsee Doshi
Vincent Y. Zhao
Will Rusch
Yuanzhong Xu
arXiv (2022)
Preview abstract
We present LaMDA: Language Models for Dialog Applications. LaMDA is a family of Transformer-based neural language models specialized for dialog, which have up to 137B parameters and arepre-trained on 1.56T words of public dialog data and web text. While model scaling alone canimprove quality, it shows less improvements on safety and factual grounding. We demonstrate thatfine-tuning with annotated data and enabling the model to consult external knowledge sources canlead to significant improvements towards the two key challenges of safety and factual grounding.The first challenge, safety, involves ensuring that the model’s responses are consistent with a set ofhuman values, such as preventing harmful suggestions and unfair bias. We quantify safety using ametric based on an illustrative set of values, and we find that filtering candidate responses using aLaMDA classifier fine-tuned with a small amount of crowdworker-annotated data offers a promisingapproach to improving model safety. The second challenge, factual grounding, involves enabling themodel to consult external knowledge sources, such as an information retrieval system, a languagetranslator, and a calculator. We quantify factuality using a groundedness metric, and we find that ourapproach enables the model to generate responses grounded in known sources, rather than responsesthat merely sound plausible. Finally, we explore the use of LaMDA in the domains of education andcontent recommendations, and analyze their helpfulness and role consistency.
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Privacy-first Health Research with Federated Learning
Adam Sadilek
Dung Nguyen
Methun Kamruzzaman
Benjamin Rader
Stefan Mellem
Elaine O. Nsoesie
Jamie MacFarlane
Anil Vullikanti
Madhav Marathe
Paul C. Eastham
John S. Brownstein
John Hernandez
npj Digital Medicine (2021)
Preview abstract
Privacy protection is paramount in conducting health research. However, studies often rely on data stored in a centralized repository, where analysis is done with full access to the sensitive underlying content. Recent advances in federated learning enable building complex machine-learned models that are trained in a distributed fashion. These techniques facilitate the calculation of research study endpoints such that private data never leaves a given device or healthcare system. We show—on a diverse set of single and multi-site health studies—that federated models can achieve similar accuracy, precision, and generalizability, and lead to the same interpretation as standard centralized statistical models while achieving considerably stronger privacy protections and without significantly raising computational costs. This work is the first to apply modern and general federated learning methods that explicitly incorporate differential privacy to clinical and epidemiological research—across a spectrum of units of federation, model architectures, complexity of learning tasks and diseases. As a result, it enables health research participants to remain in control of their data and still contribute to advancing science—aspects that used to be at odds with each other.
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Meta-Learning Bidirectional Update Rules
Andrew Jackson
Tom Madams
ICML 2021
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In this paper, we introduce a new type of generalized neural network where neurons and synapses maintain multiple states. We show that classical gradient-based backpropagation in neural networks can be seen as a special case of a two-state network where one state is used for activations and another for gradients, with update rules derived from the chain rule. In our generalized framework, networks have neither explicit notion of nor ever receive gradients. The synapses and neurons are updated using a bidirectional Hebb-style update rule parameterized by a shared low-dimensional "genome". We show that such genomes can be meta-learned from scratch, using either conventional optimization techniques, or evolutionary strategies, such as CMA-ES. Resulting update rules generalize to unseen tasks and train faster than gradient descent based optimizers for several standard computer vision and synthetic tasks.
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UIBert: Learning Generic Multimodal Representations for UI Understanding
Chongyang Bai
Srinivas Kumar Sunkara
Xiaoxue Zang
Ying Xu
the 30th International Joint Conference on Artificial Intelligence (IJCAI-21) (2021)
Preview abstract
To improve the accessibility of smart devices and to simplify their usage, building models which understand user interfaces (UIs) and assist users to complete their tasks is critical. However, unique challenges are proposed by UI-specific characteristics, such as how to effectively leverage multimodal UI features that involve image, text, and structural metadata and how to achieve good performance when high-quality labeled data is unavailable. To address such challenges we introduce UIBert, a transformer-based joint image-text model trained through novel pre-training tasks on large-scale unlabeled UI data to learn generic feature representations for a UI and its components. Our key intuition is that the heterogeneous features in a UI are self-aligned, i.e., the image and text features of UI components, are predictive of each other. We propose five pretraining tasks utilizing this self-alignment among different features of a UI component and across various components in the same UI. We evaluate our method on nine real-world downstream UI tasks where UIBert outperforms strong multimodal baselines by up to 9.26% accuracy.
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A Field Guide to Federated Optimization
Jianyu Wang
Gauri Joshi
Maruan Al-Shedivat
Galen Andrew
A. Salman Avestimehr
Katharine Daly
Deepesh Data
Suhas Diggavi
Hubert Eichner
Advait Gadhikar
Antonious M. Girgis
Filip Hanzely
Chaoyang He
Samuel Horvath
Martin Jaggi
Tara Javidi
Satyen Chandrakant Kale
Sai Praneeth Karimireddy
Jakub Konečný
Sanmi Koyejo
Tian Li
Peter Richtarik
Karan Singhal
Virginia Smith
Mahdi Soltanolkotabi
Weikang Song
Sebastian Stich
Ameet Talwalkar
Hongyi Wang
Blake Woodworth
Honglin Yuan
Mi Zhang
Tong Zhang
Chunxiang (Jake) Zheng
Chen Zhu
arxiv (2021)
Preview abstract
Federated learning and analytics are a distributed approach for collaboratively learning models (or statistics) from decentralized data, motivated by and designed for privacy protection. The distributed learning process can be formulated as solving federated optimization problems, which emphasize communication efficiency, data heterogeneity, compatibility with privacy and system requirements, and other constraints that are not primary considerations in other problem settings. This paper provides recommendations and guidelines on formulating, designing, evaluating and analyzing federated optimization algorithms through concrete examples and practical implementation, with a focus on conducting effective simulations to infer real-world performance. The goal of this work is not to survey the current literature, but to inspire researchers and practitioners to design federated learning algorithms that can be used in various practical applications.
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ActionBert: Leveraging User Actions for Semantic Understanding of User Interfaces
Zecheng He
Srinivas Sunkara
Xiaoxue Zang
Ying Xu
Lijuan Liu
Gabriel Schubiner
Ruby Lee
AAAI-21 (2020)
Preview abstract
As mobile devices are becoming ubiquitous, regularly interacting with a variety of user interfaces (UIs) is a common
aspect of daily life for many people. To improve the accessibility of these devices and to enable their usage in a variety
of settings, building models that can assist users and accomplish tasks through the UI is vitally important. However, there
are several challenges to achieve this. First, UI components of
similar appearance can have different functionalities, making
understanding their function more important than just analyzing their appearance. Second, domain-specific features like
Document Object Model (DOM) in web pages and View Hierarchy (VH) in mobile applications provide important signals about the semantics of UI elements, but these features
are not in a natural language format. Third, owing to a large
diversity in UIs and absence of standard DOM or VH representations, building a UI understanding model with high coverage requires large amounts of training data.
Inspired by the success of pre-training based approaches in
NLP for tackling a variety of problems in a data-efficient
way, we introduce a new pre-trained UI representation model
called ActionBert. Our methodology is designed to leverage
visual, linguistic and domain-specific features in user interaction traces to pre-train generic feature representations of UIs
and their components. Our key intuition is that user actions,
e.g., a sequence of clicks on different UI components, reveals
important information about their functionality. We evaluate
the proposed model on a wide variety of downstream tasks,
ranging from icon classification to UI component retrieval
based on its natural language description. Experiments show
that the proposed ActionBert model outperforms multi-modal
baselines across all downstream tasks by up to 15.5%.
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Generative Models for Effective ML on Private, Decentralized Datasets
8th International Conference on Learning Representations, ICLR 2020, Addis Ababa, Ethiopia, April 26-30, 2020, OpenReview.net
Preview abstract
To improve real-world applications of machine learning, experienced modelers develop intuition about their datasets, their models, and how the two interact. Manual inspection of raw data—of representative samples, of outliers, of misclassifications—is an essential tool in a) identifying and fixing problems in the data, b) generating new modeling hypotheses, and c) assigning or refining human-provided labels. However, manual data inspection is risky for privacy-sensitive datasets, such as those representing the behavior of real-world individuals. Furthermore, manual data inspection is impossible in the increasingly important setting of federated learning, where raw examples are stored at the edge and the modeler may only access aggregated outputs such as metrics or model parameters. This paper demonstrates that generative models—trained using federated methods and with formal differential privacy guarantees—can be used effectively to debug data issues even when the data cannot be directly inspected. We explore these methods in applications to text with differentially private federated RNNs and to images using a novel algorithm for differentially private federated GANs.
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