The No Tobacco unit (TFI) is part of the Department of Health Promotion at WHO headquarters in Geneva, Switzerland. The headquarters staff, regional and country advisers (the TFI network) work closely to plan and implement tobacco control activities in countries.

Tobacco control advisers are based in WHO's regional offices for Africa, the Americas, the Eastern Mediterranean, Europe, South-East Asia and the Western Pacific. In a handful of countries where the tobacco epidemic is particularly grave, designated tobacco control staff work in WHO country offices. The regional and country colleagues, in turn, collaborate with WHO's country representatives and liaison officers to facilitate and advance WHO's tobacco control agenda.

WHO works with the WHO FCTC Secretariat and governments in Member States to implement the tobacco control measures in the WHO Framework Convention on Tobacco Control (WHO FCTC) on the ground, to reduce the prevalence of tobacco use and exposure to tobacco smoke. By implementing these measures, governments can reduce the heavy burden of disease and death that is attributable to tobacco use or exposure.

The WHO FCTC's tobacco control measures are usually expressed as laws, regulations, administrative decisions and such actions as surveillance or enforcement measures. Some of these decisions and actions involve health systems and professionals. Governments and civil society can also engage in programmes and population-based interventions.

To help countries implement the treaty, WHO introduced MPOWER in 2007, a package of technical measures and resources, each of which corresponds to at least one demand-reduction provision of the WHO FCTC. MPOWER builds the capacity of countries to implement certain provisions of the WHO FCTC.

Tobacco control is based upon an underlying ethical framework that recognizes the rights of persons to life, health and freedom. The WHO FCTC recognizes the importance of the human rights regimens embodied in the International Covenant on Economic, Social, and Cultural Rights; the Convention on the Elimination of All Forms of Discrimination Against Women; and the Convention on the Rights of the Child.