PLVAP

PLVAP
Identifikatori
Aliasi	PLVAP, FELS, PV-1, PV1, gp68, protein povezan s veziklom plazmaleme, DIAR10
Vanjski ID-jevi	OMIM: 607647 MGI: 1890497 HomoloGene: 10578 GeneCards: PLVAP
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19p13.11 Početak 17,351,450 bp Kraj 17,377,342 bp
Lokacija gena (miš) Hrom. Hromosom 8 (miš) Bend 8 B3.3|8 34.43 cM Početak 71,950,409 bp Kraj 71,964,396 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • protein homodimerization activity Ćelijska komponenta • citoplazma • perinuklearno područje citoplazme • Kaveole • integral component of membrane • cell surface • ćelijska membrana • Egzosom • membrana Biološki proces • tumor necrosis factor-mediated signaling pathway • protein kinase C signaling • MAPK cascade • positive regulation of cellular extravasation • GO:0007571 developmental process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	83483	84094
Ensembl	ENSG00000130300	ENSMUSG00000034845
UniProt	Q9BX97	Q91VC4
RefSeq (mRNK)	NM_031310	NM_032398
RefSeq (bjelančevina)	NP_112600	NP_115774
Lokacija (UCSC)	Chr 19: 17.35 – 17.38 Mb	Chr 8: 71.95 – 71.96 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein plazmalemske vezikule je protein koji je kod ljudi kodiran genom PLVAP.

Tkivna specifičnost

Gen PLVAP eksprimira se u plućima, bubrezima, srcu, aorti, posteljici, mišićima, hipofizi, nadbubrežnim i mliječnim žlijezdama, bešici, limfnim čvorovima, koštanoj srži, dušniku, gastrointestinalnom traktu, jetri i tumorskom endotelu.

Struktura

Ovaj glikoprotein sastoji se od 442 aminokiseline, uključujuči malu N-terminalnu regiju, jedan transmembranski fragment i C-terminalni vanćelijski domen. Vanćelijski domen sadrži četiri N-glikozilacijska mjesta i dva velika super namotana alfa-heliksna domena, što ukazuje na štapičastu strukturu proteina. Veličina proteina je, ovisno o nivou glikozilacije, od 50 do 60 kDa.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MGLAMEHGGS		YARAGGSSRG		CWYYLRYFFL		FVSLIQFLII		LGLVLFMVYG
NVHVSTESNL		QATERRAEGL		YSQLLGLTAS		QSNLTKELNF		TTRAKDAIMQ
MWLNARRDLD		RINASFRQCQ		GDRVIYTNNQ		RYMAAIILSE		KQCRDQFKDM
NKSCDALLFM		LNQKVKTLEV		EIAKEKTICT		KDKESVLLNK		RVAEEQLVEC
VKTRELQHQE		RQLAKEQLQK		VQALCLPLDK		DKFEMDLRNL		WRDSIIPRSL
DNLGYNLYHP		LGSELASIRR		ACDHMPSLMS		SKVEELARSL		RADIERVARE
NSDLQRQKLE		AQQGLRASQE		AKQKVEKEAQ		AREAKLQAEC		SRQTQLALEE
KAVLRKERDN		LAKELEEKKR		EAEQLRMELA		IRNSALDTCI		KTKSQPMMPV
SRPMGPVPNP		QPIDPASLEE		FKRKILESQR		PPAGIPVAPS		SG

Dopunska literatura

• Stan RV, Ghitescu L, Jacobson BS, Palade GE (1999). "Isolation, Cloning, and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein". J. Cell Biol. 145 (6): 1189–98. doi:10.1083/jcb.145.6.1189. PMC 2133139. PMID 10366592.
• Hnasko R, McFarland M, Ben-Jonathan N (2003). "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands". J. Endocrinol. 175 (3): 649–61. CiteSeerX 10.1.1.322.5434. doi:10.1677/joe.0.1750649. PMID 12475376.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Stan RV, Tkachenko E, Niesman IR (2005). "PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms". Mol. Biol. Cell. 15 (8): 3615–30. doi:10.1091/mbc.E03-08-0593. PMC 491823. PMID 15155804.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strickland LA, Jubb AM, Hongo JA, et al. (2005). "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)". J. Pathol. 206 (4): 466–75. doi:10.1002/path.1805. PMID 15971170. S2CID 45045679.
• Carson-Walter EB, Hampton J, Shue E, et al. (2006). "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis". Clin. Cancer Res. 11 (21): 7643–50. doi:10.1158/1078-0432.CCR-05-1099. PMID 16278383.