Yourgene Health’s Post

CD3 and B-cell maturation antigen (BCMA)–bispecific antibody Teclistamab-Induced Remission in Refractory Systemic Lupus Erythematosus Need for long-term follow-up and controlled trial, but an encouraging signal. https://lnkd.in/etScpqdY

Understanding the immunogenicity assessment of therapeutic proteins. In this infographic, sponsored by ICON plc, we explore the current trends in immunogenicity assessment, including the assays used, the challenges involved with particular assays and guidance, and the future trends likely to emerge >>> https://hubs.ly/Q02PvB_J0

#Artice now available! #AAV process intensification using high-salt lysis and salt-tolerant endonuclease The increasing demand for recombinant adeno-associated viruses (#rAAVs) in high-dose clinical trials and therapeutic applications requires increased efficiency and scalability. In this article, studies with four commonly used detergents for #celllysis, including Triton™ X-100, which is banned in the European Union due to its endocrine and mutagenic effects, Polysorbate 20, Deviron® C16 detergent, and Deviron® 13-S9 detergent were conducted. Read below:

#Artice now available! #AAV process intensification using high-salt lysis and salt-tolerant endonuclease The increasing demand for recombinant adeno-associated viruses (#rAAVs) in high-dose clinical trials and therapeutic applications requires increased efficiency and scalability. In this article, studies with four commonly used detergents for #celllysis, including Triton™ X-100, which is banned in the European Union due to its endocrine and mutagenic effects, Polysorbate 20, Deviron® C16 detergent, and Deviron® 13-S9 detergent were conducted. Read below:

What makes our Phase 2 drug candidate NT-0796 unique amongst NLRP3 inflammasome inhibitors? It contains an ester delivery vehicle, designed to allow penetration of membranes and then be hydrolysed to the active species only in monocytic immune cells, which contain carboxylesterase-1. This results in unrivalled selectivity and picomolar cellular potency. This is detailed nicely in our latest publication by John Doedens et al. https://lnkd.in/eHgwQY6B

Our recombinant chimeric #VlsE for #Borrelia #Burgdorferi is a highly antigenic biomarker thanks to the multi-epitope presence in the molecule. We suggest a potential use of this chimera in the IVD diagnostics of Lyme disease, in both USA and especially in Europe, where the heterogeneity of the immunodominant epitopes must be considered. 🔗https://shorturl.at/Vn1CE #VlsE #lyme #multiepitope #RecombinantProteins #GetREKOMended

Clinical dataset demonstrates that inferring human leukocyte antigen (HLA) genotypes is highly concordant to dedicated HLA testing. https://ja.ma/3B5sO5I

ATTO-1310 for atopic dermatitis and other diseases associated with itching, and ATTO-002 for immune-mediated diseases. The two candidates are both bispecific antibodies – dubbed Attobodies – that have the ability to bind to two different targets on the same molecule and offer high affinity, enhanced internalisation into cells, as well as fast tissue penetration, according to the biotech. ATTO01310 targets IL31, while ATTO-002 hits both IL31 and IL13. #Biotech

Glucuronides of drugs as analytical standards : we cook them for you All DMPK scientists agree that producing glucuronides from test compounds can be challenging; Coupling and deprotecting sugar derivatives is notoriously tricky. ✨ Think of Starlight! ✨ We’ve prepared the glucuronide of hydroxy-chlorzoxazone for you!   This compound is formed by hepatocytes when incubated with chlorzoxazone, the best-known substrate of CYP 2E1. This P450 enzyme, localized exclusively in centrilobular hepatocytes, serves as an excellent marker for hepatocyte function and disorders, such as MASH disease (Metabolic Dysfunction-Associated Steatohepatitis). #MASH #Centrilobular #Hepatocytes #CYP2E1 #Glucuronide