Welala’s Post

Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism Recent studies on heterochronic parabiosis have revealed that small extracellular vesicles (sEVs) from young blood can rejuvenate aged tissues. 🔍 The latest research demonstrates: 💉 Intravenous injections of young sEVs extend the lifespan of aged mice. 🧬 These sEVs counter aging at molecular, mitochondrial, cellular, and physiological levels. 📈 They enhance PGC-1α expression through miRNA cargoes, improving mitochondrial function and reducing age-related declines. 🔬 Quantitative proteomics has shown significant changes in the proteomes of aged tissues, linked to metabolic improvements after sEV treatment. 🌐 This discovery opens new doors for potential therapies targeting aging and its associated diseases. From Nature aging: https://lnkd.in/gX9BeM4N #AgingResearch #Biotech #MitochondrialHealth #MedicalInnovation #ScienceNews

🧠🎉Our paper is now available online in Cell Reports by Cell Press and will be featured in the November issue (Vol 43, Issue 11) In this paper, titled “Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization”, we show that highly activated inflammatory microglia mediate remyelination in a cortical demyelination model and identify microglia sensing of solTNF through TNFR1 as an immune checkpoint in the polarization between reparative and damaging microglia with potential therapeutic relevance for CNS demyelination. A big thank you to all the co-authors from Dr. Lesley Probert lab, Laboratory of Molecular Genetics, Hellenic Pasteur Institute Athens, Greece and our collaborators from Imperial College London, UK; DIANA lab, Greece ; Center for Brain Research, Medical University of Vienna, Austria & INmune Bio Inc., USA. https://lnkd.in/d5tsM3YV Cell Reports by Cell Press Cell Press #CellReports #CellPress #microglia #remyelination #CNS

Explore the intersection of cardiometabolic diseases and mitochondria! This week could be called #lipids and #heart, given the cool papers focused on this topic!! Check it the full list below 👇 👇 👇 https://lnkd.in/g39stSA2 My highlights: -> Dapagliflozin treatment does not alter metabolites in patients with heart failure with preserved ejection fraction. Although the paper found several interesting metabolites that could be used in the future for diagnostic/treatment purposes. -> A mouse model of lipotoxicity and HFpEF. Pretty interesting time course and functional alterations. -> Mitochondrial cyclophilin D acetylation contributes to endothelial dysfunction and hypertension. Acetylation as a post-translational mechanism is becoming more solid every year and this paper is a must if you like this PTM. As always, the list was pre-sorted by Biomed News #science #technology #machinelearning #metabolism #mitochondria #obesity

"The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the mitochondrial information processing system (MIPS). In a three-step process, mitochondria (1) sense and respond to both endogenous and environmental inputs through morphological and functional remodeling; (2) integrate information through dynamic, network-based physical interactions and diffusion mechanisms; and (3) produce output signals that tune the functions of other organelles and systemically regulate physiology. This input-to-output transformation allows mitochondria to transduce metabolic, biochemical, neuroendocrine, and other local or systemic signals that enhance organismal adaptation. An explicit focus on mitochondrial signal transduction emphasizes the role of communication in mitochondrial biology. This framework also opens new avenues to understand how mitochondria mediate inter-organ processes underlying human health."

Dr. Yeran Bai and colleagues have recently published a groundbreaking paper titled "Single-cell mapping of lipid metabolites using an infrared probe in human-derived model systems" in Nature Communications, addressing the pressing need for advanced techniques in metabolic imaging, particularly at the single-cell level. The study introduces a novel approach by employing an azide-tagged infrared probe combined with Optical Photothermal Infrared Spectroscopy (O-PTIR) to enhance the understanding of lipid metabolism in cells. This innovative method offers improved specificity and efficiency in lipid detection compared to traditional methods. The study highlights the unique advantages of O-PTIR over other vibrational spectroscopy techniques, such as its immunity to fluorescence background and cost-effectiveness. The findings deepen our understanding of lipid-related metabolic diseases and pave the way for new therapeutic strategies. Bai et al.'s research marks a significant advancement in metabolic imaging, offering detailed, cell-type-specific insights into lipid metabolism and its role in health and disease. #OPTIR #azide #lipiddetection #naturecommunications

Live-cell imaging has shown that lysosomes near mitochondria participate in engulfing the herniating IMM, leading to VDIM formation through a process similar to microautophagy. This selective formation of VDIMs seems to be enhanced during oxidative stress, indicating a potential role in maintaining mitochondrial function and homeostasis. Moreover, the study highlights the importance of inter-organelle communication pathways, demonstrating that VDIM formation is dependent on calcium release by lysosomal calcium channels. This discovery sheds light on a novel intra-mitochondrial quality control pathway, allowing for the selective removal of damaged IMM sections, ultimately safeguarding mitochondria from localised injury. Mitochondrial membranes play a crucial role in defining distinct structural and functional compartments within cells. Recent research using super-resolution microscopy has revealed an intriguing process within mitochondria. During resting states, cytosolic inner mitochondrial membrane (IMM) vesicles, known as VDIMs, are formed through a unique mechanism involving IMM herniation through pores in the outer mitochondrial membrane. Overall, these findings contribute to our understanding of mitochondrial quality control mechanisms, which involve various pathways such as mitophagy, mitocytosis, and membrane-sorting pathways for the removal of specific cargo. This research underscores the intricate and coordinated activities that maintain mitochondrial homeostasis and functional integrity. Congratualtions to Akriti Prashar, PhD, Claudio Bussi, Antony Fearns, Mariana Capurro, Xiaodong Gao, Hiromi Sesaki, Maximiliano Gutierrez & Nicola Jones, at The Hospital for Sick Children, The Francis Crick Institute, Johns Hopkins Medicine Link to Nature paper: https://lnkd.in/ecFQ35Rj #electronmicroscopy #subsampling #imaging #cryoelectronmicroscopy #livecellimaging #DrugDiscovery #cryoelectronmicroscopy #Crystallography #structuralchemistry #structuralbiology #mitochondria #lysosomes #autophagy

A groundbreaking study published in Aging reveals six key chemical compounds that can partially reverse cellular ageing, restoring youthful functions in human cells within seven days! This exciting research from Harvard Medical School explores chemical reprogramming, a non-genetic approach to rejuvenate cells. This could be a game-changer, offering powerful alternatives to current gene-based therapies. The implications are vast, promising exciting possibilities for regenerative medicine and the treatment of age-related diseases. https://lnkd.in/dy3_MAr2 #Aging #RegenerativeMedicine #CellularRejuvenation #HarvardMedicalSchool #Biotechnology #HealthcareInnovation

🎉Researchers there have made a breakthrough in understanding the causes of spina bifida, a common disorder affecting the nervous system. 👶Spina bifida, also known as meningomyelocele, impacts 1 in every 3,000 newborns. 🧬But thanks to the work led by Keng Ioi Vong, Ph.D., and Sangmoon Lee, M.D. Ph.D., along with their team at UC San Diego, we're gaining new insights into this condition. 🔍Their study, recently published in the journal Science, unveils a significant connection between spina bifida and a specific chromosomal microdeletion found in humans. This microdeletion, known as 22q11.2del, is more common than previously thought and increases the risk of spina bifida by over 10 times! 🔬But here's the exciting part: the researchers also discovered a potential solution. They found that folic acid, a common food supplement, could reduce both the risk and severity of spina bifida. 💊 This research opens doors for better understanding and potentially preventing spina bifida and other neural tube defects.🚪 📙Read more about this study here: https://lnkd.in/dqMsx9iM . . . . . . . . . . . . . . . . #SpinaBifida #MedicalResearch #Neuroscience #FolicAcid #Healthcare #Science #UCSanDiego #BreakthroughDiscovery MedBound Times NewsGram M Subha M. Sonali Pradhan Jyoti Shukla Dr Anjali K V Susmita Bhandary Munish Kumar Raizada, MD, FAAP Dr.Vineesha Vasudevan Himani Negi Nirainila Joseph Aniket Bakare Akashita Panjla Dr Pragati Priya Aditi Anup Madathingal Arpit sharma

Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or human's life. Past studies have shed light on some chemical alterations to histones occurring after these proteins have been translated in a cell that could increase people's susceptibility to specific disorders or diseases. Researchers at Icahn School of Medicine at Mount Sinai recently identified a particular histone post-translational modification that is linked to a greater susceptibility to different types of stress in mice. This modification, outlined in a paper published in Neuron, is the mono-methylation (the addition of a methyl group) of the 27th lysine amino acid in the histone H3 protein, also referred to as H3K27me1. https://lnkd.in/g8BWBxUz

📢Discover the Latest Research on the HPA Axis in Health and Disease – Submit Your Manuscript Now!🌟 Join us as we delve into the intricate world of the hypothalamic-pituitary-adrenal (HPA) axis and its crucial role in both health and disease. 📚Submission Deadline: March 02, 2025🔍Research Keywords: HPA axis, hypothalamus, pituitary, adrenal, stress, epigenetics, signaling 👩🏫Guest Editor: Prof. Charlotte Steenblock, Research group leader at the Dept. of Internal Medicine III, University Clinic Carl Gustav Carus, TU Dresden, Germany. 👀What You'll Find Inside: 🌱Review: Hypothetical involvement of stress hormones-induced reprograming of adult stem/progenitor cells in tumorigenesis Read more: https://lnkd.in/g3eyNWFY 🌱Review: Genome editing in the adrenal gland: a novel strategy for treating congenital adrenal hyperplasia Read more: https://lnkd.in/gvUwr8nm 🌱Original Article: Epigenetics in etiopathology of hyperprolactinemia Read more: https://lnkd.in/gZVNFJeZ 🌱Commentary: Unique original endocrine findings: the endoplasmic reticulum-mitochondrial unit in steroid producing cells Read more: https://lnkd.in/gFnFfpge 🎯Learn more and submit: https://lnkd.in/gKgSBzwS #HPAAxis #Endocrinology #Metabolism #Stress #Epigenetics #Signaling ✨Share this with your colleagues and join the conversation!✨