TIDES: Oligonucleotides and Peptide Therapeutics’ Post

Scientists at the Centre for Genomic Regulation (CGR) in Barcelona, Spain, have identified bacteria’s latest strategy for maintaining antibiotic resistance: altering ribosomal RNA (rRNA). Read more: https://lnkd.in/eHkHnJcZ

Did you know that 𝐂𝐨𝐂𝐨𝐍𝐮𝐓𝐬 are enormously abundant in diverse prokaryotes and in a plethora of genomic associations? Find out more here: CoCoNuTs (𝐂𝐨iled-𝐂𝐨il 𝐍𝐮clease 𝐓andems) are a diverse subclass of Type IV restriction systems predicted to target RNA https://lnkd.in/gFuwVSBN

🚨 Research publication Alert: First-ever Co-infection of Mpox & Varicella-Zoster Virus (VZV) in Pakistan 🚨 In this study, we delve into the first reported case of co-infection between Mpox and VZV in Pakistan. Using advanced genomic sequencing, we uncovered novel mutations, offering crucial insights into the complex dynamics of viral coinfections. #Virology #GenomicSequencing #InfectiousDiseases #ViralCoinfection #Research #HealthcareInnovation https://lnkd.in/dN2mQd4g

In the paper, the authors explore key aspects of the complex ethical and legal landscape surrounding consent in the context of incorporating genomic sequencing into existing newborn bloodspot screening programs. https://lnkd.in/gj22-ahw

Join the Africa CDC PGI Webinar Series on Pathogen Genomic Surveillance in Africa. When? April 10th, 2024, 2:00-3:00 PM EAT Topic: Fully Automated Next-Generation Sequencing (NGS) Solutions #PathogenGenomics

Did you know that dbSNP contains various worldwide population allele frequency, molecular consequence, genomic and RefSeq mRNA and protein mapping, and publication information for both common variations and clinical mutations? Check it out: https://ow.ly/FsXn50RRClo

Please check out this article by Wenjing Cao et al @#KUPthology on how genetic variants in genes associated with #coagulation, #platelets, and #complement activation may modulate clinical presentation of #immune #thrombotic #thrombocytopenic #purpura, resulting from severe deficiency of plasma #ADAMTS13. https://lnkd.in/gR3BzKD3.

A new animal model is available for POLG associated mitochondrial reasearch, thank you JAX! CRISPR/Cas9 endonuclease mediated genome editing of polymerase (DNA directed), gamma (Polg) was used to introduce an amino acid substitution at position 292 altering arginine to cysteine (R292C). The mutation is homologous to human R309C. This strain may be useful for studies of Polg-associated mitochondrial disorders. This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. https://lnkd.in/eYuQJAHE #POLGFOUNDATION #POLG #mitochondrialdisease

Molecular mimicry: does it explain how EBV causes MS? EBV & host genetic predispositions increase your risk of MS by 260x and the presence of antibody responses against three or more cross-reactive peptides by up to 1,366x. #MS_Selfie research newsletter =>

More and more research shows the importance and relevance of microbiomes. To be able to get more insights in microbiomes, often complicated NGS library preps are needed. Microbiome profilling as easy as a simple PCR reaction? With our EasySeq™ 16S Microbiome Library Prep Kit, you can do your whole illumina library prep with just 1 PCR reaction: target amplification, indexing and adapter ligation. A one-tube, single reaction workflow with unmatched sensitivity, robustness and simplicity. Learn more on our website or contact me directly for more information about the next revolution in microbial NGS.