seqWell’s Post

Researchers Chonnam National University engineered bacteria with a gene switch system triggered by tumor colonization to treat cancer, avoiding toxicity in normal tissues. A bioluminescence-detectable gene showed a single trigger activated the bacteria's tumor-treating genes, according to work published in Molecular Imaging and Biology. Read the full article here: https://rdcu.be/dBUF3 Ngo, HTT, et al. Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy. Mol Imaging Biol 26, 148–161 (2024). #molecularimagingandbiology #MIB #genetherapy #bioluminescence #molecularimaging

🚀 Unlocking the Secrets of Cell Growth! 🚀 Ribosomes, the unsung heroes of cells, play a crucial role in gene expression. Their assembly is a meticulous and energy-intensive process, finely tuned to the cell's ever-changing needs. With recent breakthroughs, we now understand how ribosome synthesis is intrinsically connected to cell proliferation. The 5S particle, a ribosome sub-complex, emerges as a key player. It's not just about building proteins—it's about regulating critical tumor suppressors like p53 and pRB. This intricate dance influences the cellular cycle, involving pathways like p14ARF, SRSF1, and PRAS40. These insights highlight ribosome synthesis as central to cell growth and offer promising pathways for innovative cancer therapies. An exciting frontier in medicine awaits! 🌟 Read Research 👉🏻 https://lnkd.in/g2XykjPk #research #pubmed

Discover how integrating spatial transcriptomics (ST) and bulk RNA-Seq provides unprecedented insights into the tumor microenvironment of non-small cell lung cancer (NSCLC). This study reveals the power of these techniques in understanding gene expression profiles, refining target expression by cell type, and identifying variability within tumors. Download our poster to learn more about this innovative approach and its potential for personalized therapeutic strategies. https://hubs.la/Q02zQzhl0 #NSCLC #SpatialTranscriptomics #RNASeq #PersonalizedMedicine

📺 Missed our “𝑨𝑰-𝒅𝒓𝒊𝒗𝒆𝒏 𝒊𝒅𝒆𝒏𝒕𝒊𝒇𝒊𝒄𝒂𝒕𝒊𝒐𝒏 𝒂𝒏𝒅 𝒗𝒂𝒍𝒊𝒅𝒂𝒕𝒊𝒐𝒏 𝒐𝒇 𝒏𝒐𝒗𝒆𝒍 𝒔𝒚𝒏𝒕𝒉𝒆𝒕𝒊𝒄 𝒍𝒆𝒕𝒉𝒂𝒍 𝒈𝒆𝒏𝒆 𝒑𝒂𝒊𝒓𝒔” seminar? Here is what you can hear about in the recording from the event: 👉 #CRISPR advancements: Latest developments in CRISPR technology and their applications in genetic research 👉 #AI integration: How AI enhances the identification process of lethal cancer genes 👉 Practical applications: Real-world case studies showcasing high-throughput CRISPR editing and robotically enabled cell biology assays 👉 Future trends: Upcoming trends in genetic engineering and oncology targets, such as FAK Recording available here: https://lnkd.in/dthAVHdm #DrugDiscovery #DrugDevelopment #CellModels

Discover the Cutting-Edge of cancer research: Dive into our detailed poster on Spatial Transcriptomics and learn how these groundbreaking technologies are revolutionizing our understanding of NSCLC. #CancerResearch #NSCLC #SpatialTranscriptomics #RNAseq #LearnMore

If you work in #cancerresearch, understanding the function of mutations you’re interested in might just have become simpler. Cancer researchers need to accurately understand what role specific mutations play in the development, progression and treatment response of cancers. Scientists at Massachusetts Institute of Technology have developed a prime editing technique, which enables quicker and easier screening of these mutations, in their natural context. The research involved using p53 mutations to develop a tool, which works by works by editing the genome rather than by introducing a synthetic version of the mutant gene. In addition to helping researchers, it is hoped this technique could be used in the future to determine how a patient’s tumour may respond to a particular treatment. Read the full article in News Medical: https://rb.gy/0dhhpq

#HighlyCitedPapers 📝 Gene Expression Profiling in Early Breast Cancer—Patient Stratification Based on Molecular and Tumor Microenvironment Features — Munkácsy et al. In this paper, the authors aimed to evaluate the current evidence of using #gene expression signatures or profiling (GEP) in clinic and explore and discuss the increasing importance of immune parameters and the possibility to refine current tools with additional immune-GEPs that may help to refine prognosis and provide better predictive tools for early-stage breast #cancer. Full text is available 👇 https://lnkd.in/dxvmVf2x #medicine #health #research #science

💡 Dive into the cutting-edge world of cancer genomics with our latest article, where Zeynep Karagöz, our Data Engineer specialized in cBioPortal, explores a new cBioPortal feature: "orientation-aware OQL filter for gene fusion events". In cancer genomics, identifying structural variants like gene fusions is crucial. 🧬These events, often a result of chromosomal rearrangements, create hybrid genes with abnormal protein functions, impacting cancer cell growth and disease progression. Explore how this innovative feature enhances our understanding and detection of gene fusion events, advancing targeted therapies and diagnostic accuracy by reading our article: https://lnkd.in/ey2Zxb8K. #CancerGenomics #OncologyResearch #PrecisionMedicine #OncoPrint #OQL #cBioPortal

🔬 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐢𝐧 𝐂𝐚𝐧𝐜𝐞𝐫: Unveiling the Mysteries! 🎗️ - 🧬 Gene Expression Control: Epigenetic modifications can activate or silence genes without altering the DNA sequence, playing a critical role in tumor development. 🚀 - 🔍 DNA Methylation: Abnormal methylation patterns often lead to gene silencing and are key biomarkers for diagnosing various cancers. 🧩 - 🧠 Histone Modification: Changes in histone proteins affect chromatin structure and gene accessibility, influencing cancer progression. 📊 - 🌱 Therapeutic Potential: Epigenetic drugs aim at reversing harmful modifications, offering hope for more effective cancer treatments. 💊 🛠️ Streamline your research on epigenetic mechanisms in cancer with SciQst, the ultimate tool for generating comprehensive biomedical literature reviews: https://www.sciqst.com #Epigenetics #CancerResearch #BiomedicalScience #SciQst

𝐓𝐑𝐀𝐍𝐒𝐅𝐀𝐂® 𝐡𝐚𝐬 𝐛𝐞𝐞𝐧 𝐡𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐞𝐝 𝐢𝐧 𝐚 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐑𝐞𝐩𝐨𝐫𝐭𝐬 Nature Portfolio Ref: https://lnkd.in/eUENR736  The bioinformatics part of the analysis involved the TRANSFAC® database. Gene set enrichment analysis with TRANSFAC® identified several groups of transcription factors including E2F, KLF and AP-2. 𝐓𝐢𝐭𝐥𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers. Researches at the Ruđer Bošković Institute, Zagreb, Croatia aimed to reveal epigenetic biomarkers of the head and neck cancer. Integrated miRNome, methylome and transcriptome profiling was applied. #TRANSFAC #Bioinformatics #GeneSetEnrichment #HeadAndNeckCancer #Epigenetics #Methylation #TranscriptionFactors #E2F #KLF #AP2 #miRNome #Methylome #EpigeneticDrivers #CancerBiomarkers #NaturePortfolio #ScientificReports #RudjerBoskovicInstitute #CancerResearch #Oncology #SystemsBiology