Sadashiva Pai, PhD, MBA’s Post

Controlling inflammation helps in lifespan extension and aging The therapeutic drug rapamycin, which is normally used in cancer therapy and after organ transplants, can extend the lifespan and health span of laboratory animals. Understanding how rapamycin extend lifespan is important, as it helps to prevent unwanted side effects. "We know that rapamycin extends lifespan via two mechanisms: increased autophagy and decreased activity of a protein called S6K. It has been shown that mice with altered S6K live longer. But the mechanism by which S6K extends lifespan is unclear," says a co-author of the study. The researchers were able to show that an altered activity of S6K influences the endolysosomes. These break down material in the cells and play an important role in regulating various cellular processes, such as inflammatory reactions. The researchers also identified an important link between the endolysosomal system and age-related inflammation: the protein syntaxin 13. This protein is increased in the liver of rapamycin-treated mice, suggesting that the regulation of the endolysosomal system and the control of inflammatory pathways during ageing is similar between flies and mice. #ScienceMission #sciencenewshighlights https://lnkd.in/gGJV-VVa