Oncology and Cancer Research Group Journals’ Post

https://lnkd.in/eEeagAnm Article title: Radiation Recall Masquerading as an Infectious Process Author(s): Santhosshi Narayanan; Bilal Mujtaba; John Eugene Koay; Mohamed Elshikh; John E Madewell; Gauri R Varadhachary Journal: International Journal of Radiology and Radiation Oncology Journal ISSN: 2640-7566 Abstract: Cellulitis and other infections are common in cancer patients, especially patients who are immunosuppressed following chemotherapy. When patients do not respond to antimicrobial therapy as expected, it is imperative for clinicians to consider other treatment-related conditions in the differential diagnosis. One such condition unique to cancer patients who have received radiation therapy is radiation recall, which may masquerade as an infectious phenomenon and can be a recurrent issue in a previously irradiated area. We report a case of radiation recall cellulitis and myositis during treatment with gemcitabine, cisplatin, and nab-paclitaxel after radiation therapy. Upfront identification of radiation recall facilitates its timely diagnosis and management.   #Radiation #Cellulitis #Myositis #Infection #Radiationrecall   #XRayRadiography #Ultrasound #ComputedTomography #NuclearMedicine #Peertechz #PeertechzPublications #MagneticResonanceImagingMRI #PositronEmissionTomographyPET #RadiationOncology #ImagingSciences #BreastImaging #CardiovascularImaging #ChestRadiology #DiagnosticImaging #GastrointestinalImaging #GenitourinaryRadiology #Head #Neck #MusculoskeletalRadiology #NeuroimagingAndHeadAndNeck #NeuroRadiology #PediatricImaging #DiagnosticRadiology #InterventionalRadiology #RadiationPhysics #RadiationBiology #CardiopulmonaryImaging #GastrointestinalImaging #GenitourinaryImaging #MusculoskeletalImaging #Neuroradiology #HeadAndNeckImaging #NuclearMedicineAndMolecularImaging #PediatricImaging #VascularAndInterventionalRadiology #WomensImaging #ExternalBeamIrradiation #Brachytherapy #ParticleRadiationTherapy #IntraoperativeRadiationTherapy #StereotacticRadiosurgery #Radiotherapy #ExperimentalWorkInRadiobiology #TumorBiology #RadiationPhysics #Dosimetry #RadiationTreatmentPlanning

https://lnkd.in/ecZZTwnd Article title: Combination of Thrombolysis and Glycoprotein IIb/IIIa Inhibition in Chronic Peripheral Thrombosis: A Case Report Author(s): Mubin I Syed; Ryan Gallagher; Zeshan Hussain; Azim Shaikh; Philip J Cain; Kamal Morar; Matthew Sebastian; Robert Tyrrell; Allen Guehl; Ronald Erdelyi Journal: International Journal of Radiology and Radiation Oncology Journal ISSN: 2640-7566 Abstract: Currently, many interventionalists employ either tissue plasminogen activator (alteplase, Genentech, San Francisco, CA), or recombinant plasminogen activator (reteplase, Chiesi USA, Inc., Cary, NC), for peripheral thrombolysis. Further, combination therapy utilizing a thrombolytic agent and a glycoprotein IIb/IIIa receptor antagonist has been proposed as a way to overcome the limitations of thrombolytic therapy alone by reducing the duration of infusion, preventing rethrombosis, and improving the efficacy of thrombolysis. The following report discusses a patient with stenoses in the distal right posterior tibial artery. The patient underwent percutaneous transluminal angioplasty along with tissue plasminogen activator infusion therapy. Initially, the tissue plasminogen activator infusion reduced pain. However, an embolic occlusion to the distal right lateral plantar artery led to recurrence of pain. #Combinationthrombolysis #tPA #Eptifibatide #Retaplase #Alteplase #Abciximab #GPIIbIIIaantagonists #Tirofiban #Peripheralarterialdisease   #XRayRadiography #Ultrasound #ComputedTomography #NuclearMedicine #Peertechz #PeertechzPublications #MagneticResonanceImagingMRI #PositronEmissionTomographyPET #RadiationOncology #ImagingSciences #BreastImaging #CardiovascularImaging #ChestRadiology #DiagnosticImaging #GastrointestinalImaging #GenitourinaryRadiology #Head #Neck #MusculoskeletalRadiology #NeuroimagingAndHeadAndNeck #NeuroRadiology #PediatricImaging #DiagnosticRadiology #InterventionalRadiology #RadiationPhysics #RadiationBiology #CardiopulmonaryImaging #GastrointestinalImaging #GenitourinaryImaging #MusculoskeletalImaging #Neuroradiology #HeadAndNeckImaging #NuclearMedicineAndMolecularImaging #PediatricImaging #VascularAndInterventionalRadiology #WomensImaging #ExternalBeamIrradiation #Brachytherapy #ParticleRadiationTherapy #IntraoperativeRadiationTherapy #StereotacticRadiosurgery #Radiotherapy #ExperimentalWorkInRadiobiology #TumorBiology #RadiationPhysics #Dosimetry #RadiationTreatmentPlanning

HistoSonics, Inc. is extremely proud to announce the publication of our pivotal #HOPE4LIVER Trials data today. The prospective, international, multi-center, single arm #HOPE4LIVER Trials were designed to evaluate the safety and efficacy of histotripsy for the non-invasive destruction of primary (hepatocellular carcinoma) and metastatic liver tumors. Safety and efficacy were measured against performance goals established using real-world evidence from ablative therapies. The trials met the co-primary endpoints for technical success and safety, and this outcome is key as the investigators treated both primary and metastatic disease and represented a diverse group of liver experts with no prior experience performing histotripsy, signaling a quick learning curve. As a result of these early data, HistoSonics initiated planned commercialization of the Edison System in the first half of 2024, rapidly establishing histotripsy programs in leading academic and private institutions across the US and globally. To date, the accelerated clinical adoption of histotripsy has led to hundreds of histotripsy procedures completed by liver surgeons, interventional radiologists, and radiation oncologists with a high rate of success. These data are being prepared for publication later this year. Furthermore, longer-term 12-month efficacy data from #HOPE4LIVER is in analysis and in preparation for publication. We recognize the courage of the many patients and families who participated in these groundbreaking trials. Also, we are thankful to partner with visionary clinicians and hospital leaders who continue to champion histotripsy as a new category of care for their diverse patient populations. #Histotripsy #MinimallyInvasiveIsntMinimalEnough #HistoSonics

RADIATION DOSE REDUCTION SHOULD NEVER COME AT THE PRICE OF LOWERING THE DIAGNOSTIC STANDARDS BECAUSE THIS CAN IMPAIR THE WHOLE OUTCOME Ria et al. Optimization of abdominal CT based on a model of total risk minimization by putting radiation risk in perspective with imaging benefit. Commun Med (Lond). 2024 Dec 19;4(1):272. doi: 10.1038/s43856-024-00674-w. LINK: https://lnkd.in/d455v8KM The paper presents a mathematical framework for optimizing abdominal CT imaging by considering both radiation risk and clinical risk. The goal is to create a more balanced approach to CT optimization, which is traditionally focused primarily on minimizing radiation exposure. This study introduces a “total risk” model, where total risk (Rt) is defined as the sum of radiation risk (Rr) and clinical risk (Rc), and both are quantified using comparable units. This enables a more holistic assessment of the benefits and risks of CT imaging. Key points from the study include: 1. Model: The authors developed a model for estimating the total risk by incorporating various factors such as radiation burden, disease prevalence, the false-positive rate, the life expectancy loss due to misdiagnosis, and radiologist performance (AUC). 2. Liver Cancer: The model was applied to a simulated population of one million cases, focusing on liver cancer detection. The results indicated that, across all demographics, clinical risk significantly outweighs radiation risk by at least 400%. 3. Results: in over 90% of cases, increasing the radiation dose would reduce the total risk, especially for populations like the Asian group (24% total risk reduction with a 306% increase in radiation dose). The lowest potential for risk reduction was found in the Hispanic population. Justification, optimization and Limitation: these are the criteria to be adopted in radiation exposure and this has to be balanced with diagnostic power. The study concludes that optimizing abdominal CT imaging should consider both radiation and clinical risks, as the latter often outweighs radiation risk by a significant margin. The proposed total risk model demonstrates that, in many cases, increasing the radiation dose can reduce the overall risk, particularly when clinical risks are high, such as in cancer detection. This challenges the traditional focus on minimizing radiation alone and suggests that overly reducing radiation dose could harm patient care. The model provides a comprehensive approach to balancing risks and benefits, ultimately aiding in more informed and individualized imaging decisions. #CTOptimization #RadiationRisk #ClinicalRisk #MedicalImaging #RiskBenefitBalance #AbdominalCT #CancerDetection #Radiology #ImagingOptimization #PatientCare #RiskModel #TotalRisk #ImagingSafety

📢 Just out in CardioVascular and Interventional Radiology (CVIR): New insights on the treatment of hepatic hemangiomas (HHs) using transcatheter arterial embolization (TAE) with bleomycin-Lipiodol & gelatin sponge particles! 🩺💉 Explore the impact on HH treatment. 🧠 Study Focus: • Retrospective analysis across 3 centers from 2014 to 2021 • 102 patients with 109 HHs examined • Assessment of TAE's effectiveness and safety • Analysis of CT changes post-TAE 🔬 Core Results: • Significant tumor reduction post-TAE (diameter: 8.5 cm to 5.9 cm, volume: 412.6 cm³ to 102.0 cm³, both P < 0.001) • 80.7% (88/109) tumors achieved 50% volume reduction • Sustained Lipiodol retention noted within shrinking tumors over time 🧩 Key Predictors of TAE Response: • Atypical enhancement (tiny dots on CT): P = 0.001 • Central arterioportal shunt (APS) within tumor: P = 0.002 • Both associated with lower success rates of TAE effectivity 🛡️ Safety Profile: • Postembolization syndrome and transient liver enzyme increase were common • No severe complications or death reported 📌 Conclusion: TAE proves to be a safe and effective method for reducing the size of HHs. Notably, the lesion enhancement pattern and APS are crucial in predicting TAE's efficacy. Dive into the full paper: https://lnkd.in/gBk9xdHv Shoutout to the researchers behind this study! 👏 What's your experience with TAE for HH? Could these findings change your protocol? Stay ahead in the latest vascular interventions. Join our community for updates: https://lnkd.in/gRwAjsEf #VIR #iRads #Radiology #InterventionalRadiology #HepaticHemangioma #PatientSafety #LiverHealth #Embolization #MedEd #Oncology #Healthcare

Nice article by Greg Slabodkin of BioSpace on the need for proper imaging diagnosis of Alzheimer's disease as more therapies are approved. Check it out at https://lnkd.in/gtskb-5i #SNMMI24 #radiology

Our latest paper "The Paradox of Modern Technology in Standardizing Thermal Liver Ablation: Fostering Uniformity or Diversity?" got published in CardioVascular and Interventional Radiology (CVIR) as part of the IMAGIO_project. The IMAGIO consortium aims to integrate interventional oncology into the standard clinical pathway for cancer treatment in Europe by 2030. Among the main deliverables are to develop a standardized, accessible, and low-complexity high-precision workflow for thermal liver ablation and AI-based algorithms to support patient selection, treatment planning, needle guidance and treatment evaluation. During the CIRSE Congress 2023 in Copenhagen, we organized an international expert focus group discussion to assess the current and future role of modern technology in thermal liver ablation. While advancements in tools and software hold the potential to standardize outcomes and reduce operator-dependent variability, this study revealed that the rapid increase in these technologies also leads to increased workflow variation. To achieve comparable outcomes in thermal liver ablation worldwide, international standardization is needed. Available at: https://lnkd.in/e_G7-D8J Ariadne Lisa van der Velden Faeze Gholamiankhah Gonnie van Erp Pim Hendriks Ronald van Dam Hossein Rahmini Bob Knapen Rodolfo Lanocita Christiaan van der Leij Mark Burgmans And many thanks to all other co-authors! Philips

https://lnkd.in/e_wRt5ZG Article title: Non-Surgical management with Intra-Arterial Concurrent Chemo Radio Therapy (IACCRT) can be a definitive organ preservation treatment for buccal cancer patient Author(s): Andrew Yau-Wah Young; Cheng-Yo Yen; Chil-Hsin Hung Journal: International Journal of Radiology and Radiation Oncology Journal ISSN: 2640-7566 Abstract: Conventional Head and Neck cancer treatment with primary surgical intervention is a relatively suffering manipulation because of causing severe facial deformity, and mastication malfunction, and resulted in a very poor quality of life for the patients afterward. And post-operation adjuvant therapy with combined modality treatment with Concurrent Chemo-Radio Therapy (CCRT) has been recommended approach for H&N cancer for decades too. But it is also relatively more toxic to the patient, and further severely disrupts patients’ quality of life due to systemic side-effects caused by intravenous cytotoxic drug delivery. Intra-arterial infusion chemotherapy is another option for CCRT because of not only a better tumor response documented, and also bonus a better quality of life improvement.   #IACCRT #Headneckcancer #Organpreservation #Patientfriendlycare #Qualityoflife #Humanizetreatmentmodality   #XRayRadiography #Ultrasound #ComputedTomography #NuclearMedicine #Peertechz #PeertechzPublications #MagneticResonanceImagingMRI #PositronEmissionTomographyPET #RadiationOncology #ImagingSciences #BreastImaging #CardiovascularImaging #ChestRadiology #DiagnosticImaging #GastrointestinalImaging #GenitourinaryRadiology #Head #Neck #MusculoskeletalRadiology #NeuroimagingAndHeadAndNeck #NeuroRadiology #PediatricImaging #DiagnosticRadiology #InterventionalRadiology #RadiationPhysics #RadiationBiology #CardiopulmonaryImaging #GastrointestinalImaging #GenitourinaryImaging #MusculoskeletalImaging #Neuroradiology #HeadAndNeckImaging #NuclearMedicineAndMolecularImaging #PediatricImaging #VascularAndInterventionalRadiology #WomensImaging #ExternalBeamIrradiation #Brachytherapy #ParticleRadiationTherapy #IntraoperativeRadiationTherapy #StereotacticRadiosurgery #Radiotherapy #ExperimentalWorkInRadiobiology #TumorBiology #RadiationPhysics #Dosimetry #RadiationTreatmentPlanning

In today's post I discuss the role of second opinions in cancer care and how they are likely to change as interoperability and digitization of radiology and pathology reduce the cost and inconvenience of face to face second opinions.

https://lnkd.in/d9je9BTR Article title: Hyperprogression after immunotherapy in HNC: literature review and our experience Author(s): Nerina Denaro Journal: International Journal of Radiology and Radiation Oncology Journal ISSN: 2640-7566 Abstract: Checkpoint inhibitors demonstrate salutary anticancer effects, including long-term remissions. PD-L1 expression/amplification, high mutational burden, and mismatch repair deficiency correlate with response. Champiat et al for the first time described a small subset of patients that could actually have tumor growth accelerated when given PD1/PDL1-targeting agents .Hyperprogression may be defined as accelerated progression outpaces the expected rate of growth induced by the therapies.Champiat suggests that a subset of patients with disease progression have a course that is more deleterious than they might have had with other therapies, or even in the absence of therapy.   #XRayRadiography #Ultrasound #ComputedTomography #NuclearMedicine #Peertechz #PeertechzPublications #MagneticResonanceImagingMRI #PositronEmissionTomographyPET #RadiationOncology #ImagingSciences #BreastImaging #CardiovascularImaging #ChestRadiology #DiagnosticImaging #GastrointestinalImaging #GenitourinaryRadiology #Head #Neck #MusculoskeletalRadiology #NeuroimagingAndHeadAndNeck #NeuroRadiology #PediatricImaging #DiagnosticRadiology #InterventionalRadiology #RadiationPhysics #RadiationBiology #CardiopulmonaryImaging #GastrointestinalImaging #GenitourinaryImaging #MusculoskeletalImaging #Neuroradiology #HeadAndNeckImaging #NuclearMedicineAndMolecularImaging #PediatricImaging #VascularAndInterventionalRadiology #WomensImaging #ExternalBeamIrradiation #Brachytherapy #ParticleRadiationTherapy #IntraoperativeRadiationTherapy #StereotacticRadiosurgery #Radiotherapy #ExperimentalWorkInRadiobiology #TumorBiology #RadiationPhysics #Dosimetry #RadiationTreatmentPlanning