Lunaphore (a Bio-Techne brand)’s Post

🧠 A Major Breakthrough in Alzheimer’s Research 🚀 The Allen Institute just released an incredible study that traces the progression of Alzheimer’s at the molecular level—essentially mapping out the disease’s “pathological clock.” This research is a huge step forward in understanding how Alzheimer’s takes hold in the brain, and it brings real hope for earlier detection and better treatments. Some key findings that really stood out: 🔹 Scientists discovered molecular changes that happen years before symptoms start, which could open the door to earlier intervention. 🔹 They were able to pinpoint the exact timing of protein changes, offering a clearer picture of how the disease progresses. 🔹 This could help us develop therapies that target Alzheimer’s at its earliest stages, potentially slowing or even stopping the disease. Check out the full article here: https://lnkd.in/gKHfHAF7 #AlzheimersResearch #Neuroscience #BrainHealth #MedicalBreakthrough #AllenInstitute

Neuroscience Showcase In this free online event, hosted by DDW and sponsored by ApconiX, leading industry figures will outline the areas of opportunity and challenges in the neuroscience drug discovery & development sector. The showcase will include a panel discussion looking at the use of new drug discovery and development technology, concepts and tools in neuroscience, as well what the future looks like for neuroscience therapies. The showcase will also feature product presentations from sponsors that give the audience the opportunity to learn about the latest technologies driving neuroscience drug discovery and development. What you will learn: · Where is the opportunity in the neuroscience market? · How to uncover the best research tools to boost the development of new treatments · How to recognise and tackle barriers in neuroscience research · What are the technologies that can help create efficiencies and get to market faster? · What does the future hold for neuroscience? Thu, Oct 24, 2024 3:00 PM - 4:00 PM BST Register for free now to secure your place! https://lnkd.in/eAV96dhF #Neuroscience #Research #DrugDiscovery

🚀 I'm Excited to share my latest publication in the Journal of Molecular Neuroscience (Q2, IF: 2.8) ! 📚 🔬 Article Title: Understanding Signaling Pathways in Sciatic Nerve Regeneration In this comprehensive review, we delve into the complex process of sciatic nerve regeneration, focusing on the crucial signaling pathways that drive cellular responses essential for regeneration. Key highlights include: 🔸 The pivotal role of MAPK, PI3K/AKT, cAMP, and JAK/STAT pathways in neuronal survival and axonal regrowth. 🔸 Importance of Schwann cell differentiation and myelination facilitated by MAPK. 🔸 The integral part of PI3K/AKT in transcription, translation, and cell survival. 🔸 The regulatory functions of GTP-binding proteins and Notch signaling in early nerve regeneration and muscle fibrosis prevention. Our findings underscore the necessity for further research to bridge existing knowledge gaps and advance therapeutic strategies for sciatic nerve injuries. Special thanks to Saeedeh Zare Jalise for her incredible support and contributions to this project. 🙏 Thank you to my co-authors and collaborators for their invaluable efforts! Link to Article: https://lnkd.in/dK4NsWss #Neuroscience #Research #SciaticNerve #Regeneration #MolecularBiology #ScientificPublication

Exciting News: My Review on Lipid Nanoparticle Delivery for Alzheimer's Therapy! I'm thrilled to announce the publication of my review article, "Lipid nanoparticle mediated small interfering RNA delivery as a potential therapy for Alzheimer's disease," in the European Journal of Neuroscience (Impact Factor: 3.4)! This review dives into the promising potential of using lipid nanoparticles to deliver small interfering RNA (siRNA) as a treatment for Alzheimer's disease. siRNA has the potential to target specific genes involved in the disease process, offering a novel therapeutic approach. In this article, I explore: -The challenges of siRNA delivery to the brain -How lipid nanoparticles can overcome these challenges -The current state of research on siRNA-based therapies for Alzheimer's disease -Future directions for this exciting field A huge thank you to the Federation of European Neuroscience Societies and John Wiley & Sons Ltd for publishing this work. You can access the full article here: [https://lnkd.in/gxuhip6p] #AlzheimersDisease #siRNA #LipidNanoparticles #Neuroscience #Research #ReviewArticle

We are proud to have supported the Edward Smith Laboratory at Boston Children's Hospital in their innovative research exploring the role of Lectin-type oxidized LDL receptor-1 (LOX-1) in cerebral cavernous malformations (CCM), a condition impacting the central nervous system. By leveraging the Olink Proteomics Explore 3072-Plex Panel, our proteomics team contributed critical data on protein expression in urine samples. These findings, published in Frontiers in Neuroscience, advance understanding of LOX-1 as a biomarker and therapeutic target for CCM. Congratulations to the authors on this significant achievement! Read the full paper here: https://lnkd.in/dqRkGydN #Proteomics #Neuroscience #Innovation #CCM #Research

🧠 𝐁𝐫𝐚𝐢𝐧 𝐎𝐫𝐠𝐚𝐧𝐨𝐢𝐝𝐬 𝐟𝐨𝐫 𝐍𝐞𝐮𝐫𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 🚀 - 🌱 Tiny Brains, Big Impact: Brain organoids replicate miniature brain structures, offering a revolutionary model for studying complex neurological phenomena in a dish! - 🔍 Disease Insights: These 3D models offer unprecedented insights into diseases like Alzheimer's and autism, helping to unveil the mysteries of the human brain one cell at a time. - 🧬 Genetic Exploration: Organoids facilitate genetic and developmental studies, enabling researchers to manipulate and observe changes with incredible precision, leading to a deeper understanding of human brain development. - 🤝 Collaborative Innovation: A cross-disciplinary marvel, brain organoids bring together biologists, neuroscientists, and bioengineers, propelling breakthroughs in personalized medicine and novel therapies. Dive deeper into the world of brain organoids with a tailor-made review at SciQst to fuel your next discovery: https://www.sciqst.com 🌐 #BrainOrganoids #Neuroscience #MedicalResearch #Innovation #SciQst

Neuroscience Showcase In this free online event, hosted by DDW and co-sponsored by ApconiX and AxoSim, leading industry figures will outline the areas of opportunity and challenges in the neuroscience drug discovery & development sector. The showcase will include a panel discussion looking at the use of new drug discovery and development technology, concepts and tools in neuroscience, as well what the future looks like for neuroscience therapies. The showcase will also feature product presentations from sponsors that give the audience the opportunity to learn about the latest technologies driving neuroscience drug discovery and development. What you will learn: · Where is the opportunity in the neuroscience market? · How to uncover the best research tools to boost the development of new treatments · How to recognise and tackle barriers in neuroscience research · What are the technologies that can help create efficiencies and get to market faster? · What does the future hold for neuroscience? Thu, Oct 24, 2024 3:00 PM - 4:00 PM BST Register for free now to secure your place! https://lnkd.in/eAV96dhF #Neuroscience #Research #DrugDiscovery

We are excited to invite you to the second webinar in the MaxWell Webinar Series, featuring Dr. Matt Kelley from Alexion-AstraZeneca Rare Disease, USA. 🤩 Dr. Matt Kelley will present on the topic "Progressing Neuroscience Drug Discovery through HD-MEAs" and will cover the following topics: 🔵 HD-MEA use cases in drug discovery research featuring ex-vivo and in-vitro preparations. 🔵 A human model of Dravet syndrome, using patient-derived iPSC neurons characterized by HD-MEAs. 🔵 High-throughput spike sorting analysis to assess neuronal responses to ion channel potentiators. 🗓 Tuesday, October 22 🕘 17:00 CEST | 08:00 PDT | 11:00 EDT | 23:00 CST | 00:00 JST Are you interested? Register for free 👉 https://lnkd.in/disYBgqg Make sure to join us live, as no recording will be available afterwards. See you online! #Webinar #Neuroscience #Research #drugdiscovery #iPSC

☑️ *READ ABSTRACT BELOW:* Keywords: Microenvironment; Molecular biology; Neuroscience; Omics; Techniques in neuroscience; Transcriptomics Glioblastoma is a highly aggressive malignant tumor of the central nervous system, but the interaction between glioblastoma and different types of neurons remains unclear. Here, we established a co-culture model in vitro using 3D printed molds with microchannels, in which glioblastoma organoids (GB), dorsal forebrain organoids (DO, mainly composed of excitatory neurons), and ventral forebrain organoids (VO, mainly composed of inhibitory neurons) were assembled. Our results indicate that DO has a greater impact on altered gene expression profiles of GB, resulting in increased invasive potential. GB cells preferentially invaded DO along axons, whereas this phenomenon was not observed in VO. Furthermore, GB cells selectively inhibited neurite outgrowth in DOs and reduced the expression of the vesicular GABA transporter (VGAT), leading to neuronal hyperexcitability. By revealing how glioblastoma interacts with brain cells, our study provides a more comprehensive understanding of this disease. Fan Q, iScience. 2024 Feb 5;27(3):109111. doi: 10.1016/j.isci.2024.109111. PMID: 38390494; PMCID: PMC10882168 #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Discover the story behind the newly launched UCLB spinout Trace Neuroscience, and the inspiring journey behind its new hope for motor neuron disease. Launched with one of the largest biopharma Series A capital investments in recent years, Trace Neuroscience is based on research originating from UCL and Stanford University where both academic teams were unravelling the role of UNC13 in motor neuron disease. The decline in people’s ability to produce this vital protein characterises almost all cases of motor neuron disease. Trace Neuroscience was formed to commercialise the cutting-edge research at UCL and Stanford and to take on the challenge of bringing a treatment through clinical trials. UCLB licensed the intellectual property exclusively from UCL to Trace Neuroscience. Professor Pietro Fratta, MD, PhD, Professor of Cellular and Molecular Neuroscience at University College London (UCL) said: “This large funding round was pivotal for us to rapidly translate this science into a life-changing medicine and advance our lead programme towards the clinic. UNC13A is critical for neurons to communicate amongst each other and with muscles, and is lost in nearly all ALS cases. Being able to re-establish this is groundbreaking.” #ALS #GenomicMedicine #TechTransfer #BioPharm 📖 Read the case study here: https://lnkd.in/ehpPiBsx