Cyagen’s Post

From May 12th to 15th, 2025, the 3rd Electronic Conference on Biomedicines will take place. I am honored to chair Session S4: Immune System, Tumor Immunology, and Autoimmune Disease. https://lnkd.in/dEV-94ej Biomedicines MDPI #immunesystem #autoimmunity #rheumatoidarthritis #tumorimmunology #conference #research #immunology #immunomics

A glimpse into the world of PBMCs! After a successful isolation using density gradient centrifugation method, visualizing these cells under the microscope is a crucial step in ensuring a successful isolation and confirms the viability of the pbmc population for downstream applications. The journey from blood sample to this beautiful image is a reminder of the power of scientific techniques and the incredible complexity of our bodies, and how even the tiniest cells can play a critical role in health and disease. This image shows viable PBMCs, ready to be used for further experimentation, contributing to advancements in immunology, cell therapy and countless other research areas. #PBMCIsolation #Hemacytometer #Immunology #Research #Microscopy #Labwork

🎉 Exciting News! 🎉 I'm thrilled to share that our latest research paper, "Acid ceramidase expression reduces IFN𝛄 secretion by mouse CD4+ T cells and is crucial for maintaining B-cell numbers in mice," has been published in Frontiers in Immunology! 🔍 Key Findings: In our study, we discovered that ceramide was accumulated in our induced Ac-KO mice. This, in turn, led to 1) an increased IFN𝛄 secretion by CD4+ T cells without changing the production of the cytokine itself and 2) a reduction in mature B cells, plasma blasts, and plasma cells. 💡 Why This Matters: These findings are crucial as they shed light on the role of acid ceramidase in immune regulation, potentially opening new therapeutic pathways for immune-related diseases. This research could have significant implications for immune responses in viral infections and autoimmune conditions. 📖 Check out the full paper here: https://lnkd.in/daj33G8Z Big thanks to my supervisor Niklas Beyersdorf, co-authors: Claudia Hollmann Rehan haider Zaidi Dominik Wigger Fabian Schumacher, and everyone who supported this research! #Research #Immunology #Science #AcidCeramidase #TCells #BCells #ImmuneSystem #AcademicPublishing #ProudMoment

Meet Dr. Nan Zhang, an immunologist in Wistar’s Immunology, Microenvironment and Metastasis Program. As a researcher, Zhang studies the role of immune cells called macrophages in tumor growth and metastasis in the abdominal cavity and ovaries. He compares immunology to a “battlefield” where different types of cells act as soldiers with different weapons and abilities to fight cancer and other diseases. Zhang says he’s always looking for new approaches or ways to look at a problem from different angles. “Being creative is how you find solutions in science,” he says. Learn more about Zhang’s research here. https://lnkd.in/grGtC5Ci #Immunology #CancerResearch #Immunotherapy #BiomedicalResearch #WistarScience #MeetTheScientist

🚀 New Discoveries in Immune System Regulation with FIDA Technology Our users from Research Complex at Harwell published 2 groundbreaking studies, which advance our understanding of molecular mechanisms driving immune regulation: 1️⃣ Autoantigen TRIM21 (Ro52) assembles pro-inflammatory immune complexes following lytic cell death https://lnkd.in/dpPK38KQ This explores how TRIM21 forms immune complexes after cell death, offering critical insights into autoimmunity and inflammation. 2️⃣ The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures https://lnkd.in/dpKTgDBm In this article, our users uncovered the structural mechanisms behind SYK activation, a key player in immune signaling pathways, paving the way for therapeutic innovations. 🔍 Have you noticed how the FIDA platform enabled precise, in-solution measurements for vastly different biological questions? From immune complex formation to allosteric kinase activation, from translational research to structural biology. Actually, if you dig deeper, you will notice that FIDA's applications range goes further than immunology, covering the areas of neurology, LLPS, oncology and more. Access our publications base to explore: https://lnkd.in/drbaYYww 💡 Why FIDA? With its ability to measure affinity, kinetics, and aggregation, FIDA provides researchers with unparalleled insights into molecular behavior in complex systems. 🧪 Dive into the findings through the links above, and let’s celebrate how innovative tools like FIDA empower breakthroughs in science!

📃 AI-Health Research Machine learning-based new classification for immune infiltration of gliomas. New machine learning model classifies glioma immune subtypes, revealing insights into tumor microenvironment and immunotherapy potential. 🧠💉 https://lnkd.in/d676udze

What can you do with CyTOF® in your research? ✨ Study immune populations in bone marrow and the impact of their interaction with myeloma cells on tumor growth and survival ✨ Understand cell features that cause myeloma by identifying signaling pathways that can be targeted with therapies for improved outcomes and minimal toxicities ✨ Monitor disease progression and response to therapy in serial patient samples ✨ Stratify serial patient samples by disease-resistant cell populations and cell signaling pathways that predict the risk of relapse Explore cell populations and biological systems with unprecedented depth: https://lnkd.in/gk3jX_bt

🌟 Exciting Breakthrough inGlioblastoma Research!🌟 I'm thrilled to share a groundbreaking study that sheds new light on the complex interactions within the glioblastoma (GBM) microenvironment. Researchers have discovered that tumor cell-derived spermidine (SPD) plays a crucial role in promoting a pro-tumorigenic immune environment by inhibiting CD8+ T cells. This finding is a significant step forward in understanding how GBM tumors evade the immune system. 🔬 Key Highlights: Spermidine's Role: Elevated levels of spermidine in the GBM microenvironment contribute to tumor aggressiveness by reducing the frequency and cytotoxic function of CD8+ T cells. Immune Suppression: The GBM microenvironment is rich in immunosuppressive factors, making it challenging for cytotoxic T lymphocytes to function effectively. Therapeutic Potential: Knocking down ornithine decarboxylase, the enzyme responsible for spermidine synthesis, can reduce tumor aggressiveness, suggesting a potential therapeutic target for GBM treatment. 💡 Why This Matters: This discovery opens new avenues for developing targeted therapies that could improve the prognosis for GBM patients. By focusing on the metabolic pathways that cancer cells exploit, we can design more effective treatments that enhance the immune system's ability to fight cancer. 🔗 Read More: For those interested in the detailed findings, I highly recommend diving into the full study to explore the intricate mechanisms at play. Let's continue to support and celebrate the incredible advancements in cancer research. Together, we can make a difference! #CancerResearch #Glioblastoma #Immunotherapy #MedicalBreakthrough #StemCellTherapy #Oncology #HealthcareInnovation #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratoryMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology

CART cells in autoimmune disease: "Here we apply a combination of single cell RNA sequencing and T/B cell repertoire analysis to perform an in-depth characterization of molecular changes in the immune-signature upon CD19 CAR T cell-mediated depletion of B cells in SLE patients. The resulting datasets do not only confirm a selective CAR T cell-mediated reset of the B cell response, but simultaneously reveal consequent changes in the transcriptional signature of monocyte and T cell subsets that respond with a profound reduction in type 1 interferon signaling." #Immunology #Autoimmunity #CARTcells #Immunotherapy https://lnkd.in/d7jZbn9p