Proud that we were invited to present among the top companies and KOLs in the fibrosis field at the International Conference on Tissue Repair, Regeneration, and Fibrosis! Geoffrey Teixeira, our SVP Head of Fibrosis, will give a presentation titled: ‘Targeting Claudin-1 as a novel therapeutic approach to reverse organ fibrosis’, where he will discuss our clinical-stage mAb lixudebart (ALE.F02) developed for kidney, liver and lung #fibrosis. The conference is held Oct 22-27 in Heraklion, Greece. Find more information on the conference here: https://lnkd.in/eEW7B6Ra #AlentisTherapeutics #Claudin #CLDN1
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Investigating extracellular vesicles derived from normothermic liver perfusion: in their latest study, David P. Al-Adra at University of Wisconsin-Madison and collaborators isolated extracellular vesicles produced during normothermic ex vivo liver perfusion (NEVLP), a novel liver storage method, to investigate the immunological effects of liver-derived EVs in a physiologically relevant and transplant-relevant model https://lnkd.in/g3u_QDfW They found that EVs produced by the liver during NEVLP contained multiple anti-inflammatory miRNAs and could suppress the immune response in allogeneic mixed lymphocyte reactions in a concentration-dependent manner. An article co-authored by Heather Jennings, STACEY MCMORROW, Peter Chlebeck, Grace Heise, Mia Levitsky, Bret Verhoven, John Kink, Kristin Weinstein and Seungpyo Hong #extracellularvesicles #exosomes #concentration #organtransplantation #liver #Vesiculab
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Neurosurgeon | Complex Spine Surgeon | Professor | Clinical Investigational Device Developer
Cervical arthroplasty has proven benefits and is a critical pillar of the spinal motion preservation program at Loma Linda University Health. Enabling technology in the operating room with Synaptive Medical exoscopes makes this procedure safer, more effective, and more efficient. Centinel Spine NuVasive Orthofix ZimVie
Neuroscientist, Chairman, CEO & Scientific Dir of SBMT, President & Scientific Dir of WBMF, Dir. NCNBE, Dir, BTIP, Co-Founder president and CEO Aramis Therapeutics, Editor of: Nanoneurosurgery, Neurophotonics
Spinal artificial disc placement by Dr. Namath Hussain, MD, MBA in the bioskills lab of 21st annual world congress of Society for Brain Mapping & Therapeutics (SBMT) become a member and participate in our hands on course www.WorldBrainMapping.Org
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📰 New Read: Report on the Cellular Therapies in Non-Malignant Haematology Meeting ➡️ https://lnkd.in/dktY_knm 👥 This joint Educational Meeting took place mid-September in Genova, hosted by the Severe Aplastic Anaemia and Haemoglobinopathies Working Parties of the #EBMT. 💡 Dive into the insightful summary by Matilde Cossutta and Giulia Consiglieri, covering the key takeaways of the event, including: ● Hemoglobinopathies ● Bone marrow failure syndromes ● Innovative therapies and non-transplant treatments #HCT #CellularTherapies #haematology #educationalmeeting #BMT #transplantation
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Developing strategies for extracellular vesicles as future cardiac therapeutics: in this concise review, Laura Guerricchio, Sveva Bollini at Università degli Studi di Genova and Lucio Barile at Istituto Cardiocentro Ticino - EOC Ente Ospedaliero Cantonale discussed the key therapeutic potential of EVs released by human progenitors for cardiovascular disease, focusing on recent strategies to enhance myocardial targeting and optimise administration routes https://lnkd.in/e5dRZcwP They noted that precise functional assessment of EV release and uptake could provide crucial insights, advancing scientific knowledge and accelerating progress in the regenerative field. #extracellularvesicles #exosomes #heartdiseases #drugdelivery #Vesiculab
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This book https://bit.ly/43xTzsH provides the readers with the latest advances and insights in the ever-expanding field of Cardio-Oncology. Editors: Valentina Mercurio, Federico II University, Italy .Pasquale Pagliaro, University of Turin, Torino, Italy and National Institute for Cardiovascular Research (INRC), Italy Claudia Penna, University of Turin, Torino, Italy and National Institute for Cardiovascular Research (INRC), Italy Raffaella Rastaldo, University of Turin, Torino, Italy #cardiooncology #cardiotoxicity #inflammation #vasculartoxicity #systemichypertension #arrhythmias #heartfailure #biomarkers #metabolomics
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Pathologist|Dermatopathologist|Educator|Maturing amateur photographer|Dreamer| Malayali
Cell block of pleural fluid showing Malignant cells(adenocarcinoma lung). Also seen are reactive mesothelial cells, which may be difficult to differentiate morphologically. But IHC for TTF1 will demarcate the adenocarcinoma lung cells.
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LifePearl™ microspheres (Terumo) are polyethylene glycol (PEG) embolization microspheres that can be loaded with chemotherapeutic drugs including doxorubicin, irinotecan, idarubicin and epirubicin¹. Philippe Pereira (SLK-Kliniken GmbH, Heilbronn, Germany) speaks to Interventional News about his experience using LifePearl™ microspheres in his interventional oncology practice. He shares his knowledge on how to achieve the optimal transarterial chemoembolization (TACE) procedure, and how the latest pooled analysis data from hepatocellular carcinoma (HCC) patients reinforce the evidence on efficacy and safety of drug-eluting microspheres (DEM) TACE with LifePearl™ microspheres in patients with HCC. #Terumo #LifePearl #HCC #InterventionOncology #InterventionalRadiology
💡Looking for ways to minimize #TACE's impact on liver function? Reducing the impact of DEM-TACE on Biliary toxicities is one of the main considerations. Explore our latest reported DEM-TACE clinical outcomes👇. Stay tuned for more insights to come🔗: https://lnkd.in/d6Di96Mv #interventionaloncology #livercancer
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NEW from #ASCOGU 2024 | #Sacituzumab govitecan and other ADCs in #prostatecancer 🇺🇸 🎥 Umang Swami, MD, MS, University of Utah School of Medicine, comments on the various #antibodydrugconjugates (ADCs) being investigated for #prostatecancer, including #sacituzumabgovitecan The ADC consists of a trop-2-directed #antibody linked to SN-38, the payload. Dr Swami additionally highlights nectin-4-directed antibodies in #clinical trials💡 Take a look 👉 https://lnkd.in/eGDPnMmR #VJOncology #PCsm
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Could gas plasma technology be an effective #Glioblastoma treatment? 🧠 In today's #JournalClub study, scientists at Leibniz Institute for Plasma Science and Technology (INP Greifswald) e.V. cultured ATCC HaCaT keratinocyte and glioblastoma #CellLines to investigate — learn more at Cancers MDPI: https://okt.to/LzQB2E
Gas Plasma Exposure of Glioblastoma Is Cytotoxic and Immunomodulatory in Patient-Derived GBM Tissue
mdpi.com
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Happy to share that our latest comprehensive review paper on the role of fibroblasts in large-vessel vasculitides (LVV) has been published in Autoimmunity Reviews! In this review we discuss the pivotal role of fibroblasts in giant cell arteritis (GCA) and Takayasu arteritis (TAK) and explore how fibroblasts may contribute to the initiation and progression of inflammatory processes in large-vessel vasculitides. In addition, we discuss potential therapeutic targets and strategies involving fibroblasts to improve treatment outcomes and identified critical questions and future research directions to enhance our understanding of the role of fibroblasts in LVV. Special thanks to first author Shuang Xu and senior author Maria Sandovici for driving this collaborative effort. Janette Burgess Elisabeth Brouwer Niels van der Geest Mieke Boots William Febry Jiemy, PhD https://lnkd.in/eUwDfBau #Vasculitis #Fibroblasts #Autoimmunity #GCA #TAK #UMCG
Current evidence on the role of fibroblasts in large-vessel vasculitides: From pathogenesis to therapeutics
sciencedirect.com
As fibrosis continues to be a complex and pressing issue, it’s great to see Alentis Therapeutics pushing forward with innovative solutions that could redefine therapeutic approaches. Looking forward to hearing more insights from Geoffrey Teixeira’s presentation at the conference!