Aladdin Scientific’s Post

☀️ Location Matters: The Role of Spatial Biology in Understanding Cells ☀️ What a cell does depends not just on the genes it expresses or the proteins it produces, but also on its location within an organ or tissue. But many molecular experiments analyze cells in bulk, or even break down tissue samples into individual cells, which strips away information about where a given cell was within its original tissue, who its cellular neighbors were, what signals it received from those neighbors, and how those spatial relationships might influence its functions. Scientists are working on powerful "spatial -omics" techniques that collect in-depth molecular profiles from individual cells while retaining detailed information about each cell's original location. By studying single cells in ways that capture their native environment, these methods are revealing more than ever before about how cells work and the mechanisms of disease. For more info: https://lnkd.in/gSwRgX9u Broad Institute of MIT and Harvard #SpatialBiology #SpatialOmics #SingleCell #CellBiology #MolecularBiology #TissueMicroenvironment #BiomedicalResearch #CellularMicroenvironment #Genomics #Proteomics #Transcriptomics #SystemsBiology #SpatialTranscriptomics #DiseaseMechanisms #InnovativeResearch

Join us tomorrow for this webinar on using image-based spectral cell sorting and single-cell multiomics to gain new insights about immune biology. Register for the webinar: https://lnkd.in/gzxQTkM8 #epigenomics #transcriptomics #spectralflowcytometry #ATACseq #singlecellmultiomics #BDRhapsody #BDBiosciences Moen Sen, Ph.D. Hye-Won Song

Paper Alert! Excited to see our review article on 1D cell migration published in Frontiers in Cell and Developmental Biology. Our understanding of cell migration has immensely profited from studying cells move in one-dimensional confinements, such as on microfabricated lanes. In our article we review 1D migration assays, reflect on the advantages of such platforms and discuss popular biophysical models of cell migration. We highlight the unique opportunity of reproducible and standardised 1D assays to validate theory based on statistical measures from large data of trajectories and discuss the potential of experimental settings embedding controlled perturbations to probe response in migratory behaviour.   Find out more here: https://lnkd.in/gP7dWW_q

📢 Exciting Milestone in Structural and Molecular Biology! 📢 As 2024 comes to a close, we celebrate 30 years of extraordinary advancements in the field of structural and molecular biology, as highlighted in the recent article published by Nature Structural & Molecular Biology. 🎉 Over the past three decades, these disciplines have profoundly shaped our understanding of life at the molecular level, enabling breakthroughs in drug design, genome editing, and the elucidation of complex biological mechanisms. Today's research continues to transform our insights into disease pathways and biotechnological applications, charting a promising path for future discoveries. As we look forward, one wonders: what revolutionary developments will the next 30 years bring? For a comprehensive reflection, explore the article [here](https://lnkd.in/epF8umAH). Published on December 12, 2024. #StructuralBiology #MolecularBiology #ScientificAdvancement #NaturePublishing 2024-12-12T00:00:00.000Z

Contextualize tissue microenvironments with multiomics workflows, including targeted proteins, using the neofleX. This benchtop mass spectrometer provides no compromise on quality and provides more insight per pixel. Register here for this LabCast, which will cover the utility of spatial biology for disease-based research: https://lnkd.in/gmSKpDEP #maldiimaging #hiplex #spatialbiology #bruker

If you want to know more what your #proteins #lipids #peptides and cohorts are doing and want to understand the #interactions have a look at #Bruker labcast.

Missed the live session? Don’t worry - our webinar on demand is available! Watch Now: https://ow.ly/z2su50Uhmh0 Explore MolBoolean, an innovative method for analyzing protein interactions directly in cells and tissues. Learn how this groundbreaking technique provides unparalleled insights into free and interacting protein fractions, redefining molecular biology research. Featuring insights from leading expert Professor Ola Söderberg. #MolBoolean #webinar #proteininteractions #proximityligation

🔬🌟 Exciting news! We've launched new products: mRNA & LNPs Fluorescent labelled! 🚀 Discover how these innovative tools can enhance your research in molecular biology. 💡 mRNA Fluorescent ➡ https://bit.ly/3IHe5y9 LNPs Fluorescent & Double Fluorescent ➡ https://bit.ly/3vjzKJJ Learn more about fluorescent labeling and its importance in our latest article: "mRNA and LNPs: A Guide to Fluorescent Labeling to Enhance Research." 📝 Dive into the world of mRNA and LNPs, understand the techniques, factors to consider, best practices, applications, and future perspectives. 💬 Ready to elevate your research game? Head over to our website and check out the full article now: https://bit.ly/4ciG1pI Don't miss out on the latest advancements in molecular biology! 🌐🔍 #mRNA #LNPs #FluorescentLabeling #MolecularBiology #Research 🧬🔬

🔬🧬 𝐂𝐚𝐩𝐭𝐮𝐫𝐢𝐧𝐠 𝐅𝐢𝐛𝐫𝐨𝐛𝐥𝐚𝐬𝐭𝐬 𝐢𝐧 𝐌𝐨𝐭𝐢𝐨𝐧: 𝐀 𝐋𝐢𝐯𝐞-𝐂𝐞𝐥𝐥 𝐈𝐦𝐚𝐠𝐢𝐧𝐠 𝐒𝐭𝐮𝐝𝐲 🧫📸 ✅✅ Researchers utilized live-cell imaging to observe fibroblasts in motion, demonstrating a distinctive "front wheel drive" mechanism to navigate through a protein matrix. 🧫 This matrix was designed to replicate the 3-D environment found within the human body, providing valuable insights into cellular movement and interactions within complex tissue structures. 🧠 The cutting-edge live-cell imaging technique allows us to study cellular movement and behavior in real-time, offering insights into how cells interact within their natural environment. ✨ This research is a big step forward in understanding fibroblast mobility, which plays a crucial role in tissue repair and development. 🧬❗ 𝗙𝗼𝗹𝗹𝗼𝘄 👉Muhammet Furkan Bolakar and 𝗮𝗰𝘁𝗶𝘃𝗮𝘁𝗲 𝘁𝗵𝗲 𝗯𝗲𝗹𝗹𝗹 🔔 for more exciting updates on cell biology, science, and research. #Cell #Biology #LiveCellImaging #Fibroblast #Movement #Proteinweb #Research #Innovation #Cellularbehavior #Scientificdiscovery #NIDCRresearch #NIH #Molecularbiology #FibroblastDynamics #LiveCellImaging #Cellmotility #3DCellCulture #TissueRepair #CellBiologyResearch #Proteinmatrix #Cellularmovement

My desire is to inform and stimulate the discussion about the improper use of the word "Exosomes". Scientific literature (PubMed) discusses of exosomes only of human and animal origin. Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They are mediators of near and long-distance intercellular communication in health and disease and affect various aspects of cell biology. Unfortunately, the name Exoxome is used improperly by also associating it with the plant world. It is more correct to talk about of Plant Nanovesicles and not of Exosomes. Plant nanovesicles are nanometer in size and are carriers of molecules essential to life including proteins, bioactives, lipids, and nucleic acids.