Admera Health’s Post

Two of the most common types of molecular tests available on the market currently are: 1) RT-PCR (Reverse Transcription Polymerase Chain Reaction) and 2) RT-LAMP (Loop-mediated isothermal amplification). Both are nucleic acid amplification tests (NAATs), however, LAMP tests are known to have false positive rates as high as 1 in 10 samples due to promiscuous enzymes amplifying the wrong target. Make sure you understand the difference as it can be costly. Reach out to see how we can help! #HLVdtest #HLVdtesting #TissueCulture #PlantTissueCulture #3RBiotech #3RTesting

Upgrading your lab to benchtop automated #DNA/#RNA extraction? Explore the Maxwell® page for all the available kits, application notes and features across our RSC, RSC 48 and FSC models. https://bit.ly/3USs5w8 💧 Obtain purified nucleic acids ready for #NGS and #qPCR workflows. ⏱ Save at least 40 minutes hands-on time per run with load-and-go methods. ⚙ Process 1–16 or 1–48 samples at once. #lifescience #biotech

Structure–activity relationship (SAR) studies are fundamental to drug and agrochemical development, yet only a few synthetic strategies apply to the nitrogen heteroaromatics frequently encountered in small molecule candidates1,2,3. Here we present an alternative approach in which we convert pyrimidine-containing compounds into various other nitrogen heteroaromatics. Transforming pyrimidines into their corresponding N-arylpyrimidinium salts enables cleavage into a three-carbon iminoenamine building block, used for various heterocycle-forming reactions. This deconstruction–reconstruction sequence diversifies the initial pyrimidine core and enables access to various heterocycles, such as azoles4. In effect, this approach allows heterocycle formation on complex molecules, resulting in analogues that would be challenging to obtain by other methods. We anticipate that this deconstruction–reconstruction strategy will extend to other heterocycle classes. https://lnkd.in/guQc_kr3

Identied following high throughput screening using scalable thiol reactivity (STRP), chemical libraries for intrinsic reactivity with cysteine, Azetidinyl oxadiazole, adds to a handful of known electrophiles that selectively reacts with cysteine through a ring opening-based mechanism, capable of covalently engaging cysteine residues broadly across the human proteome. The publication further demonstrates the utility of this reactive group with the discovery of an azetidinyl oxadiazole containing a small molecule that augments the catalytic activity of the deubiquitinase UCHL1 in vitro and in cells by covalently modifying a cysteine distal to its enzymatic active site. https://lnkd.in/g2QYcqP6

https://lnkd.in/dDNZb_rB A palladium-catalyzed cyclization reaction of phenols with trifluoromethyl-containing ortho-bromo-β-chlorostyrenes

Explore the #Illumina PIPseq #singlecell assay and gain an overview of how to explore it with Illumina #bioinformatics tools including DRAGEN, Partek Flow, and Correlation Engine. You will learn the basic steps in tertiary scRNA-Seq analysis. Register at: https://lnkd.in/dmXz5_XV

Explore the #Illumina PIPseq #singlecell assay and gain an overview of how to explore it with Illumina #bioinformatics tools including DRAGEN, Partek Flow, and Correlation Engine. You will learn the basic steps in tertiary scRNA-Seq analysis. Register at: https://lnkd.in/eRbbrkes

Did you know that Monarch butterflies have evolved to be able to eat the poisonous milkweed plant? Learn more about how our Monarch purification kits have evolved here: https://lnkd.in/enHEKzU8

Structure-Activity Relationship (SAR) studies are fundamental to drug and agrochemical development, yet only a few synthetic strategies apply to the nitrogen heteroaromatics frequently encountered in small molecule candidates. Here, Paton et al. present an alternative approach where they convert pyrimidine-containing compounds to various other nitrogen heteroaromatics. Transforming pyrmidines into their corresponding N-arylpyrimidinium salts enables cleavage into a three-carbon iminoenamine building block, used for various heterocycle-forming reactions. This deconstruction-reconstruction sequence diversifies the initial pyrimidine core and enables access to various heterocycles, such as azoles. In fact, this approach allows heterocycle formation on complex molecules, resulting in analogs that would be challenging to obtain by other methods. They anticipate this deconstruction-reconstruction strategy will extend to other heterocycle classes.

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