The Ohio State University College of Engineering

Our Enginuity Podcast "Entrepreneur Tour" continues! In the latest episode, Dean Ayanna Howard chats with alumnus Michael Triplett about his biotech entrepreneurial journey, including past successes and current endeavors. He also offers some sage advice to current Buckeyes. Listen via Apple Podcasts or YouTube: https://lnkd.in/dmKbmX-H

Disposal of food waste is a major contributor to greenhouse gas emissions, as decomposition in landfills releases methane, a potent greenhouse gas, and incineration produces carbon dioxide and other pollutants. So Beenish Saba, a research scientist in the Department of Food, Agricultural & Biological Engineering, is working to harness industrial food processing waste and convert it into valuable platform chemicals through innovative fermentation techniques, including both conventional and electro-fermentation. https://lnkd.in/gbD4a8He

Prof. Tanya Berger-Wolf was a recent guest on Scientific American's fantastic podcast, Science Quickly. The Imageomics Institute director explains how AI and machine learning are being used to change the way we understand—and protect—animals and their ecosystems 🦓 🦋 🐘 🐋 https://lnkd.in/gMJFpJMz It's the second episode of their Friday Fascination miniseries “The New Conservationists" by Rachel Feltman & Ashleigh Papp.

Researchers are shining a light on cancer cells’ energy centers – literally – to damage these power sources and trigger widespread cancer cell death.  In a new study, a team led by Professors Lufang Zhou & Margaret (Xiaoguang) Liu combined strategies to deliver energy-disrupting gene therapy using nanoparticles manufactured to zero in only on cancer cells. Experiments showed the targeted therapy is effective at shrinking glioblastoma brain tumors and aggressive breast cancer tumors in mice.  The research team overcame a significant challenge to break up structures inside these cellular energy centers, called mitochondria, with a technique that induces light-activated electrical currents inside the cell. They named the technology mLumiOpto. “We disrupt the membrane so mitochondria cannot work functionally to produce energy or work as a signaling hub. This causes programmed cell death followed by DNA damage – our investigations showed these two mechanisms are involved and kill the cancer cells,” said Zhou. “This is how the technology works by design.” The study appears in the December issue of the journal Cancer Research. Kai Chen of Liu’s lab and Patrick Ernst of Zhou’s lab were co-first authors of the study. Additional co-authors were Anusua Sarkar, Seulhee Kim, Yingnan Si, Tanvi Varadkar and Matthew Ringel, all of Ohio State. https://lnkd.in/gYfqt_5P

The Association of American Universities (AAU) recently highlighted the Ohio State-led Midwest Semiconductor Network, which supports the onshoring of the advanced semiconductor and microelectronics industry by developing innovative solutions to meet its research and workforce needs. https://lnkd.in/esPD6EuV

👏 Congrats to recipients of the latest round of Center for Medical & Engineering Innovation (CMEI) Pilot Grants: ▪️ Megan Ballinger, PhD (Pulmonary, Critical Care and Sleep Medicine, Internal Medicine) and Aleksander Skardal, PhD (Biomedical Engineering) Project: Validation of a Humanized Fibrotic Lung-on-a-Chip System ▪️ Michelle Nassal, MD, PhD (Emergency Medicine) and Emre Ertin, PhD (Electrical and Computer Engineering) Project: Towards Personalized Intervention Protocols for Cardiopulmonary Resuscitation: Digital Twin Modeling of the Cardio-Pulmonary System in Distress Using Reduced Order Models of Physiology and Generative AI Techniques ▪️ Juliet Varghese, PhD (Biomedical Engineering) and Saurabh Rajpal, MD (Cardiovascular Medicine, Internal Medicine) Project: Developing a Single-Session Cardiopulmonary CPET-CMR Exam at Low-Field MRI CMEI fosters interdisciplinary research through multiple initiatives that engage Ohio State faculty, staff, trainees, students and extramural entities whose focus is to expand innovation and impact at the intersection of medicine and engineering. The CMEI pilot grant program supports collaborations between Ohio State colleges that initiate promising ventures at the medicine-engineering interface. Proposed research involve at least one faculty member from the College of Engineering and one faculty member from one of the Health Sciences Colleges. These collaborations test innovative approaches (ideas, technologies, devices) directed at basic or clinically relevant biomedical research. The program funds $35,000 grants to assist faculty in obtaining preliminary data that will result in a collaborative grant application for the NIH, or another agency or foundation, or lead to an entrepreneurial endpoint such as a patent. More info: https://lnkd.in/gFRXwJpK

Retrieving information from electronic health records (EHRs) efficiently and effectively while in the clinic can be difficult for clinicians. A team of Ohio State Engineering researchers aims to solve this dilemma for clinicians and ultimately improve healthcare outcomes. Led by Computer Science & Engineering Professor Xia Ning, the team has developed a method using machine learning and AI to facilitate quick and accurate information retrieval from EHRs and make search term recommendations to physicians, thus reducing their cognitive load and supporting clinical decision-making. https://lnkd.in/gkHwBm9u EHRs contain extensive collections of patient health information. Clinicians typically retrieve this information through manual browsing or searching; however, given the time constraints they often face, accessing the most important patient information, such as prior findings, symptoms, and lab results from EHRs, could be challenging during patient care in the clinic. There remains a need for improved methods and systems that can accurately and proactively identify the most useful EHR information to clinicians, said Ning, who also holds faculty appointments in the Department of Biomedical Informatics and the College of Pharmacy. “Given a patient’s historical encounters and the search terms clinicians have used, our method is developed to accurately suggest EHR information items to clinicians that are most relevant to developing the diagnoses and treatment plans for the patient,” she said. “By proactively suggesting relevant EHR information, it could reduce clinicians’ time and effort in searching for information manually, which is a tedious process.” Collaborators include former Ohio State postdoc Zhiyun Ren, Bo Peng and Indiana University Prof. Titus Schleyer. A patent (US 12062436) for their work was issued in May 2024.

🏆 Meet our extraordinary, award-winning EcoCAR team! ⤵️

Happy Commencement Day! 🎓 Congratulations to our 530 College of Engineering graduates‼️

A director of engineering at Google in Redmond, Washington, Jayanthi Sampathkumar ’97 MS ’99 MS developed personal resilience and explored her academic passions as an international graduate student from India. “I am eternally thankful for the opportunity to study at The Ohio State University. My four-year experience was life changing and taught me so much. I developed resilience to withstand the cold weather, I learned how to make friends in a new place, and I followed my passions in and out the classroom,” reflects Sampathkumar. In 2021, Sampathkumar established the Google Cloud Data Analytics team in Hyderabad, India. She was promoted to director of engineering for the data analytics teams in India in 2022. Currently she leads a team that builds automation for data security and operational efficiency of Google data centers in Washington. Read her profile: https://lnkd.in/gPipV-_4 #BuckeyeForLife The Ohio State University Alumni Association