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SATURDAY SCIENCE “It has been incredibly hard to manipulate these types of complex plant compounds for the benefit of drug design,” says senior author Ryan Shenvi, PhD, professor at Scripps Research. “The ability to now combine virtual predictions with real-world experimentation marks a turning point in how we design and build molecules.” https://lnkd.in/ekfE_wiS

"Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to explain why. Now, in new research from the Perelman School of Medicine at the University of Pennsylvania, Shelley Berger, PhD, the Daniel S. Och University Professor and Director of Penn’s Epigenetics Institute, and Katherine Alexander, PhD, currently an assistant professor at Cold Spring Harbor Laboratory have found a possible source of this variability in clear cell renal cell carcinoma (ccRCC)—the most common kidney cancer diagnosed in adults. The findings of their study are published this week in Nature Cell Biology." https://lnkd.in/efvsjxEv

“Lissencephaly belongs to a group of disorders we call malformations of cortical development, meaning the normal development and structure of the brain is disrupted,” said Angeliki Louvi, professor of neurosurgery and of neuroscience at Yale School of Medicine (YSM) and co-senior author of the study. “They come about because certain genes that are very important for brain development are affected by rare mutations.” https://lnkd.in/eQSM7JXq

Wishing you a Happy New Year filled with good health, happiness, and continued growth🎉

"Former President Jimmy Carter, who died Sunday, Dec. 29, at age 100, lived for nearly a decade after being treated with a breakthrough cancer drug developed at UCLA Health. The treatment co-developed by Antoni Ribas, MD, PhD(Link opens in new window), a professor of medicine at the David Geffen School of Medicine at UCLA, helped extend President Carter’s life and allowed him to maintain his busy schedule. President Carter, a Nobel Prize winner and lifelong human-rights activist, was able to continue painting, writing books, teaching Sunday school, volunteering with Habitat for Humanity and remaining a prominent public figure well into his 90s. After receiving the 2015 diagnosis of metastatic melanoma — the deadliest and most aggressive form of skin cancer — President Carter was treated with the immunotherapy drug pembrolizumab (Keytruda)(Link opens in new window), a groundbreaking shift in the treatment of melanoma and other malignant cancers." https://lnkd.in/eiYdxSsm

SATURDAY SCIENCE "In this season of short days and long winter nights, it’s easy to feel out of sorts. Those who suffer from seasonal affective disorder, a form of depression that’s closely linked to the circadian rhythms that govern our sleep cycles, know this all too well. But those same rhythms, which are themselves governed by biological clocks, can affect much more than mood and sleep. Sofia Axelrod, a Research Associate in the Laboratory of Genetics headed by Nobel laureate Michael D. Young, explains how our circadian system works, its far-reaching influence—and how to keep it running smoothly." https://lnkd.in/ekZugMHc

"In the final AMA Update episode of 2024, AMA Chief Experience Officer Todd Unger looks back on another year of stories about the work that physicians are doing across the country and how the AMA is fighting to support them." https://lnkd.in/eA54qZFr

#HappyHanukkah🕎 May the Festival of Lights bring you peace and joy✨

“Setting boundaries and focusing on shared connections can go a long way toward diffusing tension,” says Nadine J. Kaslow, PhD, vice chair and professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine and chief psychologist at Grady Health System. “The holidays are an opportunity to foster connection, and with a little preparation and mindfulness, it’s possible to create a positive experience for everyone.” https://lnkd.in/eU8nwgPX

Wishing you a joyful and safe holiday season filled with peace, happiness, and cherished moments. #HappyHolidays!❄️☃️