BrainKey

BrainKey

Technology, Information and Internet

San Francisco, California 1,687 followers

Brain Longevity Management

About us

BrainKey is an AI-driven digital healthcare company with a mission to create a world free from dementia. The company specializes in developing advanced clinical technologies that empower longevity physicians to detect and prevent cognitive decline. By analyzing brain MRI and biomedical data, BrainKey provides highly accurate and personalized brain health insights, supporting physicians in delivering tailored care for brain longevity.

Website
http://brainkey.ai/
Industry
Technology, Information and Internet
Company size
2-10 employees
Headquarters
San Francisco, California
Type
Privately Held
Founded
2018
Specialties
Neurology, AI, Neuroscience, Psychiatry, Brain, Deep Learning, Brain Scans, brain health, preventive health, MRI, preventive analytics, longevity, and preventative medicine

Locations

Employees at BrainKey

Updates

  • Exciting!

    View profile for Lara Lewington, graphic

    Broadcaster and journalist. AI & future health (and other tech). Lead Presenter, BBC Click. 'AI Agony Aunt', ITV Loraine. Documentary maker.

    'Mind Over Matter'. My brain ageing documentary is here. If you have an age and a brain, do watch! Featuring what we can learn from the residents of the Blue Zone that is Loma Linda, Bryan Johnson's newest experiments, human lessons from animal hibernation, and the latest science from Stanford, Berkeley and University of Southern California. Online: BBC iPlayer: https://lnkd.in/eMuAxWEc On TV: BBC One on Breakfast (short version) 7.45am Sunday UK: BBC News 7.30pm tonight / 1.30pm tomorrow International BBC News times: https://lnkd.in/eHCGexgV Huge thank you to all involved: the residents of Loma Linda, Andrei Irimia, Jordan Shlain, MD, Bryan Johnson, Owen Phillips, Ph.D., Ashley Zehnder / Fauna Bio, Leanne Williams, Matthew Walker, PhD, all the comms people juggling in the background, and the squirrels for coming out to play when we needed them. Also to the small but perfectly formed production team: cameraman Ben Derico, editor John Matthews, exec Clair Stevens, and of course to Monica Soriano and Dominic Ball for letting us loose on my vision.

    Click - Mind Over Matter

    Click - Mind Over Matter

    bbc.co.uk

  • ❤️

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    This is just the beginning. Augmented Reality (AR) is on the brink of revolutionizing how we interact with technology—and healthcare is no exception. With companies like Google/Samsung, Apple (Vision Pro), and Meta investing heavily in AR, the possibilities are endless. At BrainKey, we believe AR will play a critical role in the future of patient-provider interactions. As telemedicine continues to grow (1 in 4 U.S. adults used telehealth in 2023), AR offers a game-changing opportunity to enhance remote consultations with richer, more immersive experiences. Imagine this: a doctor and patient interacting with a 3D model of the patient’s brain in real time during a remote consultation. At BrainKey, our AI-powered platform’s tech is ready for this future. AR has the potential to make healthcare more engaging, effective, and personalized. This is just the beginning. The image here was taken by Alp Can Karacakol at the wonderful ARENA2036 campus. Thanks to Cyber Valley and Florian Mayer for setting up this talk. #AugmentedReality #DigitalHealth #Innovation #AI #Telemedicine #Neurology #Longevity #Aging #PreventiveCare #FutureOfHealthcare

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  • 🧠 + ❤️

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    Did you know? Small vessel disease is found in over 50% of people aged 65 and older. Small vessel disease is often silently contributing to cognitive decline and dementia. Recent research highlights how hypertension, a leading driver of small vessel disease, compromises brain health by disrupting energy delivery, weakening the blood-brain barrier, and fueling neuroinflammation. The good news? Managing blood pressure can significantly reduce these risks, offering a proactive path to preserving cognitive longevity. In my latest blog post, I explore the critical connection between hypertension, small vessel disease, and brain health—breaking it down into three essential pillars: 1) Energy Delivery and Metabolism 2) Toxin Clearance and Blood-Brain Barrier Integrity 3) Neuroinflammation and Cognitive Decline Discover how understanding this link can help us take actionable steps toward better brain health and longer cognitive resilience. References Hainsworth AH, Markus HS, Schneider JA. Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia. Hypertension. 2024;81:75–86. doi:10.1161/HYPERTENSIONAHA.123.19943. #aging #cardiology #bloodpressure #vascularneurology #BrainHealth #Hypertension #Longevity #SmallVesselDisease #DementiaPrevention #VascularHealth #CognitiveLongevity #Neuroscience

    Hypertension: The Silent Threat to Brain Longevity

    Hypertension: The Silent Threat to Brain Longevity

    Owen Phillips, Ph.D. on LinkedIn

  • ❤️ + 🧠

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    How does the liver, a vital organ far from the brain, play a role in neurodegenerative diseases like multiple sclerosis and Alzheimer’s? An exciting study by Magliozzi et al. (2024) sheds new light on choroid plexus inflammation in multiple sclerosis, highlighting its critical role in disrupting brain homeostasis. This research got me thinking—how do broader neurovascular abnormalities tie into conditions like these? And what role does fibrinogen, a protein produced by the liver, play in this intricate puzzle? In my latest blog, I explore: The fascinating new findings on choroid plexus inflammation in MS. How fibrinogen links vascular health, brain inflammation, and cognitive decline. The underappreciated connection between liver function and brain health—especially as we age. This research reminds us that protecting brain health starts with understanding the whole-body connections that sustain it. At BrainKey, we focus on bridging these complex relationships between systemic health and brain longevity. Our AI-powered brain MRI analyses assess markers of vascular health and brain aging. We aim to empower individuals and physicians to take proactive steps in preserving cognitive health. New MS research: Magliozzi R, et, al: Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis. Brain Pathol. 2024 Dec 1:e13322. doi: 10.1111/bpa.13322. PMID: 39617422. #aging #neurology #BrainHealth #MultipleSclerosis #Neurovascular #Longevity #Neuroinflammation #Fibrinogen #LiverHealth #BrainKey

    It’s All Connected: Exploring the Role of Fibrinogen in Neurovascular Health, MS and Liver Aging

    It’s All Connected: Exploring the Role of Fibrinogen in Neurovascular Health, MS and Liver Aging

    Owen Phillips, Ph.D. on LinkedIn

  • ❤️ + 🧠

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    How Healthy is Your Heart, and What Does it Mean for Your Brain? Did you know that your cardiovascular fitness directly impacts your brain health? Research shows that: A strong heart ensures your brain gets the energy it needs to thrive. Good vascular health protects the blood-brain barrier, shielding your brain from harmful toxins. Regular physical activity reduces neuroinflammation, supporting cognitive resilience as we age. The Lancet Commission (2024) estimates that up to 50% of dementia cases are preventable with early intervention. Monitoring cardiovascular health—like resting heart rate and blood pressure—offers a critical opportunity to safeguard your cognitive longevity. To learn more about the science behind cardiovascular fitness and brain health, and how early action can make a difference, check out the full blog post here: #longevity #aging #neurology #cardiovascular #cardiology #BrainHealth #Longevity #CognitiveHealth #CardiovascularFitness #VascularHealth #BloodPressure #BrainKey

    Cardiovascular Fitness and Brain Health

    Cardiovascular Fitness and Brain Health

    Owen Phillips, Ph.D. on LinkedIn

  • ❤️ + 🧠

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    Resting Heart Rate, Brain Health, and Preventing Cognitive Decline Did you know that resting heart rate, often considered a marker of cardiovascular health, is also deeply connected to brain health? A 2022 study published in Alzheimer's Research & Therapy found that higher resting heart rates are associated with a greater risk of dementia, faster cognitive decline, and even structural changes in the brain. This research highlights how cardiovascular and neurological health are more intertwined than we often realize. Here’s why this connection matters: Higher resting heart rates may signal underlying vascular challenges that restrict blood flow to the brain. Over time, reduced cerebral blood flow can contribute to cognitive decline and increase the risk of neurodegenerative diseases. The brain’s vascular system—responsible for delivering oxygen and nutrients—relies on a delicate balance. Even subtle disruptions in cardiovascular health can impact this system, leading to long-term brain health challenges. The good news? A proactive approach to brain and vascular health can make a significant difference. According to The Lancet’s 2024 landmark study, ~50% of dementia cases are preventable with early action and interventions. How BrainKey Helps: we empower physicians and patients by providing advanced AI-driven analysis of brain MRI data. Our platform offers insights into brain aging and vascular patterns, helping users better understand factors influencing cognitive health. By offering these insights, BrainKey supports informed discussions between patients and their healthcare providers about brain longevity. Key Takeaway: Your resting heart rate isn’t just a number—it’s a window into the health of your brain. Proactively managing cardiovascular health, paired with tools that provide insights into brain health, can help protect cognitive function and support longevity. References Deng et al., Alzheimer’s Research & Therapy (2022): Associations of resting heart rate with incident dementia, cognition, and brain structure: a prospective cohort study of UK biobank The Lancet (2024): Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission #longevity #aging #cardiology #neurology #BrainHealth #VascularHealth #RestingHeartRate #DementiaPrevention #CognitiveLongevity #EarlyIntervention #Lancet #Neuroscience

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  • Blood pressure is linked to brain health!

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    Did you know that blood pressure plays a direct role in the brain’s health? A groundbreaking study published in Hypertension earlier this year [van den Kerkhof et al., 2024] demonstrated how higher blood pressure is directly linked to the integrity of the blood-brain barrier. The researchers found that elevated blood pressure weakens the blood-brain barrier, allowing harmful substances to infiltrate the brain. This breakdown sets the stage for inflammation and neurodegenerative processes. Why does this matter? Because the blood-brain barrier acts as the brain’s fortress. When it’s compromised, the risk of conditions like Alzheimer’s and vascular dementia rises. To underscore this connection, another large international study spanning four major cohorts [Ward et al., 2024, JAMA Neurology] revealed that blood pressure is a key driver of frailty trajectories that precede dementia by over a decade. The study tracked nearly 30,000 participants and showed that frailty—a state often exacerbated by poorly managed hypertension—was strongly associated with future dementia risk. Key Findings: Higher blood pressure = weaker blood-brain barrier integrity, as shown by the Hypertension study. Frailty linked to poor vascular health, including blood pressure variability, predicts dementia risk years before cognitive symptoms appear. Blood pressure management is a critical lever in protecting the blood-brain barrier, reducing frailty, and preventing cognitive decline. What can we do? Maintaining optimal blood pressure levels in midlife can significantly reduce the risk of later-life dementia. Combined with proactive strategies like vascular health monitoring, personalized interventions can help preserve both cognitive health and longevity. At BrainKey, we work to quantify and assess brain vascular health, providing insights into blood-brain barrier integrity and brain aging. By tracking these factors, we aim to empower physicians and individuals to take control of their brain health. Further Reading: van den Kerkhof M et al., Hypertension, 2024: Blood-Brain Barrier Integrity and Blood Pressure Ward DD et al., JAMA Neurology, 2024: Frailty Trajectories Preceding Dementia Takeaway: Blood pressure isn’t just about heart health—it’s deeply intertwined with the brain’s resilience and cognitive longevity. #longevity #aging #neurology #BloodPressure #BrainHealth #DementiaPrevention #VascularHealth #CognitiveLongevity #Neuroscience #BrainKey #BloodBrainBarrier

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  • 🧠 ❤️

    View profile for Owen Phillips, Ph.D., graphic

    CEO of BrainKey

    Did you know? The choroid plexus, a tiny but essential structure in the brain, produces about 500 milliliters of cerebrospinal fluid (CSF) every day—enough to fill an entire water bottle! This fluid is crucial for cushioning the brain, delivering nutrients, and clearing waste. But what happens when the choroid plexus isn’t functioning properly? Disruptions to CSF production can lead to a cascade of effects, impacting everything from brain structure to cognitive health. To learn more about the role of the choroid plexus and the impacts of abnormal CSF regulation, and why we BrainKey work so hard to monitor brain health, check out our latest blog post! #Vasculature #BloodPressure #Stenosis #BloodFlow #Longevity #NeuroLongevity #BrainHealth #CSFHomeostasis #ChoroidPlexus #Neuroinflammation #CognitiveHealth #BrainLongevity #BrainKey

    When CSF Homeostasis Goes Wrong: The Impact of Vascular Health on Brain Function

    When CSF Homeostasis Goes Wrong: The Impact of Vascular Health on Brain Function

    Owen Phillips, Ph.D. on LinkedIn

  • BrainKey reposted this

    How Blood Flow Impacts Brain Structure: The Role of the Choroid Plexus and Neuroinflammation Did you know that the choroid plexus—a small but essential structure responsible for producing cerebrospinal fluid (CSF) and maintaining the blood-CSF barrier—undergoes significant changes when blood flow is compromised? Disruptions in cerebral blood flow don’t just affect neurons; they impact the choroid plexus, setting off a cascade of effects that can impact brain health. Abnormal Blood Flow Reduced or irregular blood flow, often due to conditions like carotid artery stenosis, restricts oxygen and nutrient supply to the choroid plexus, compromising its critical role in filtering and producing CSF. Choroid Plexus Dysfunction and Ventricular Enlargement When blood flow is disrupted, the choroid plexus can lose structural integrity, weakening the blood-CSF barrier. This leads to imbalances in CSF production and clearance, contributing to increased ventricle size. Enlarged ventricles place pressure on surrounding brain regions, which can negatively impact brain function and resilience. Increased Neuroinflammation A compromised choroid plexus allows inflammatory cells and molecules to enter the brain, fueling neuroinflammation. This chronic inflammation, combined with ventricular enlargement, accelerates cognitive decline and elevates the risk of neurodegenerative conditions. At BrainKey, we are dedicated to precisely measuring vascular health and other key brain metrics. By tracking these changes over time, we provide early insights into factors like choroid plexus health and ventricular enlargement—proactive measures that support the maintenance of long-term brain health. For a deeper dive into this topic, I recommend reading the recent study “Carotid artery vascular stenosis causes blood-CSF barrier damage and neuroinflammation” published in Journal of Neuroinflammation. This paper explores how chronic cerebral hypoperfusion, resulting from carotid artery stenosis, impacts the choroid plexus and blood-CSF barrier, leading to immune cell infiltration and neuroinflammation in brain regions. Additionally, an interesting study from the EMBARC trial suggests that choroid plexus morphology may even predict treatment response in mood disorders, highlighting its potential as an often-overlooked but vital area for brain health research. Key takeaway: Vascular health is not just about circulation; it’s foundational to the brain’s resilience and overall structural health. #Vasculature #BloodPressure #Stenosis #BloodFlow #Longevity #NeuroLongevity #BrainHealth #Neuroinflammation #ChoroidPlexus #CognitiveHealth #BrainLongevity #BrainKey Carotid artery vascular stenosis causes blood-CSF barrier damage and neuroinflammation. J Neuroinflammation. 2024; 21(1):220. doi: 10.1186/s12974-024-03209-1. Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study. Res Sq [Preprint]. 2023; rs.3.rs-2618151.

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  • BrainKey reposted this

    The Blood-Brain Barrier: A Vital Defense that Depends on Vascular Health The blood-brain barrier (BBB) plays a crucial role in protecting the brain, allowing essential nutrients in while keeping neurotoxins out. However, the BBB’s integrity relies heavily on vascular health. When blood flow is compromised, the BBB can become “leaky,” allowing harmful substances to enter the brain and increasing the risk of neurodegenerative conditions. Detecting subtle changes in vascular health, such as brain hyperintensities and microvascular changes, can reveal early signs of BBB compromise. This is why we at BrainKey, we work to measure the brain’s vascular health, providing insights that support proactive brain health strategies. There is also increased focus by biotech companies to develop therapies that specifically target the blood-brain barrier. For example, a recent paper published in Neuron highlights the potential of NAD+ to rescue blood-brain barrier damage, offering promising avenues for protecting brain health over time. Key takeaway: Protecting blood flow is also protecting the BBB—an essential defense for cognitive health and longevity. #bloodbrainbarrier #neurology #longevity #pharma #alzheimers #therapeutics #BloodBrainBarrier #VascularHealth #BrainProtection #Neurodegeneration #Neuroscience #BrainKey Reference: Zhan R, et al. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Nov 15;111(22):3634-3649.e7. doi: 10.1016/j.neuron.2023.08.010. Epub 2023 Sep 7. PMID: 37683629.

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