As we say goodbye to 2024 and look to 2025, we reflect on a year of incredible progress, milestones, and momentum at Alltrna. Together, we’ve pushed the boundaries of #tRNA therapeutics, driven by our vision to build a better future for patients. #StopCodonDisease #WeAreAlltrna #BiggerLeaps #FlagshipFounded
Alltrna
Biotechnology Research
Cambridge, Massachusetts 7,226 followers
The world’s first transfer RNA (tRNA) platform company. We are unlocking the vast therapeutic potential within #tRNA.
About us
Alltrna is the first transfer RNA (tRNA) platform company, and our mission is to unlock tRNA biology and pioneer tRNA therapeutics to regulate the protein universe and resolve disease. Founded at Flagship Labs in 2018, Alltrna has mapped tRNA biology to systematically design tRNA medicines and encode a completely new, unifying approach to treating both rare and common human diseases driven by shared genetic mutations. Alltrna’s platform combines internal expertise and proprietary machine learning tools to unlock the entire tRNA biology space. We have an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
- Website
-
http://www.alltrna.com
External link for Alltrna
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- Cambridge, Massachusetts
- Type
- Privately Held
- Founded
- 2018
Locations
-
Primary
Get directions
Cambridge, Massachusetts, US
Employees at Alltrna
Updates
-
The Alltrna team spread some holiday cheer with a festive cookie swap! From classic sugar cookies to creative new bakes, our team brought their A-game (and their aprons) to share the sweetness of the season. A big thank you to everyone who participated – and wishing everyone a joyful and delicious holiday season! 🍪🎁✨
-
Science isn’t just serious business at Alltrna—it’s fun, too! Meet Jalyce Heller, a molecular biologist who loves diving into #tRNA complexity and being part of such an engaged, motivated team. 🎥 Watch the full video to learn about her journey and what excites her most about being part of Alltrna (SPOILER: some of it involves cats 😺) #WeAreAlltrna #lablife #tRNAbiology #EmployeeSpotlight #tRNAmedicines
-
Without tRNAs, we wouldn’t have proteins that carry out the functions of life. And when a tRNA can't do its job properly, due to mutations like premature termination codons, the resulting proteins might be incomplete and/or unable to function properly. Alltrna is developing medicines to rescue such proteins and restore function. In this informative interview with David Wild for the In Vivo Podcast, Alltrna CEO Michelle Werner explains how engineered tRNAs could transform the treatment landscape for rare diseases, and the company's journey to the clinic. Listen here on Citeline Commercial: https://lnkd.in/g8AeV4Xg #InVivo #podcast #WomenInBiopharma #tRNAmedicines #tRNA #rarediseases #raredisease #StopCodonDisease #geneticmedicines #programmablemedicines #AI #machinelearning
-
We are excited to share that Shiva Krupa has joined the Alltrna team as VP, Head of Program Management! With deepexpertise in program and portfolio strategy, Shiva is poised to drive our programs from discovery through clinical development. Her extensive background includes leadership roles at Orna Therapeutics, AskBio, and Homology Medicines, where she advanced gene therapy programs across diverse therapeutic areas such as neuromuscular, cardiovascular, and oncology indications. Join us in welcoming Shiva K., to Alltrna! #tRNAmedicines #tRNA #rarediseases #raredisease #StopCodonDisease #geneticmedicines
-
-
🌟 Congratulations to our CEO, Michelle Werner, for being named one of 𝟮𝟬𝟮𝟰’s #𝗙𝗶𝗲𝗿𝗰𝗲𝟱𝟬 by FierceHealth and Fierce Life Sciences! 🌟 At Alltrna, under Michelle’s leadership, we are pioneering a bold approach using engineered tRNA to restore protein function, with the potential to unify the treatment of genetic diseases with the same mutation. It is this kind of visionary science, coupled with Michelle’s steadfast commitment to the rare disease community, that drives us to push boundaries and build a new future for patients. 🙌 Read more here: https://lnkd.in/gBEHQeVe #tRNAmedicines #tRNA #rarediseases #raredisease #StopCodonDisease #geneticmedicines
I am honored to be recognized as one of 𝟮𝟬𝟮𝟰’𝘀 #𝗙𝗶𝗲𝗿𝗰𝗲𝟱𝟬 by FierceHealth and Fierce Life Sciences. As many of you know, I am driven by a deep personal connection to doing better for patients – from my first position in cancer clinical trials to my son's diagnosis of Duchenne muscular dystrophy – I am committed to developing new medicines to improve the treatment of these devastating diseases. At Alltrna, we are pioneering a novel approach using engineered tRNA to restore protein function, with the potential to treat hundreds of genetic diseases with a single medicine. It is ambitious, it is challenging, but it is the kind of innovation that can truly transform lives. I am grateful for the support of the rare disease community, who inspire me daily with their resilience and determination. Together, we are going to keep driving progress and doing better for patients who have been underserved for far too long.
-
-
We are pleased to announce the presentation of the first preclinical data on AP003, our lead development candidate. The engineered tRNA from this drug candidate showed clinically meaningful protein restoration in Stop Codon Disease models of methylmalonic acidemia (MMA) and phenylketonuria (PKU). These data support the potential for a basket approach to developing AP003 to treat genetic liver diseases caused by an Arg-TGA premature termination codon. See the press release for more info: https://lnkd.in/gvP4Hh-Z #NatureConferences #tRNAmedicines #tRNA #rarediseases #raredisease #StopCodonDisease #geneticmedicines
-
Are recent advancements in drug development bringing us closer to new medicines for thousands of rare diseases where there currently are no treatments? Alltrna CEO Michelle Werner will join a Science Magazine hosted webinar with other industry leaders to discuss how technology -- and the work of patients and advocates themselves -- are pushing the field forward. 𝗕𝗿𝗶𝗴𝗵𝘁 𝗯𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝘀: 𝗥𝗲𝗮𝗹 𝘀𝘁𝗼𝗿𝗶𝗲𝘀 𝗼𝗳 𝗯𝗲𝗮𝘁𝗶𝗻𝗴 𝗿𝗮𝗿𝗲 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 📆 Thursday, December 12, 2024 ⏰ 9am PT / 12pm ET / 5pm GMT / 6pm CET 🔗 https://lnkd.in/g4VcPWP6 #tRNAmedicines #tRNA #rarediseases #raredisease #StopCodonDisease #geneticmedicines #patientpower
-
-
Alltrna’s CSO Chris Henderson will be presenting at RNA at the Bench and Bedside IV hosted by Nature Conferences taking place December 9-11 at The Salk Institute in La Jolla, California. This event brings together research leaders to explore the latest advancements in translating RNA and tRNA biology into innovative therapies. We are excited to share more about how Alltrna is developing tRNA medicines to treat Stop Codon Disease. For more info on the conference, visit: https://lnkd.in/eu89e9uJ #NatureConferences #tRNAmedicines #tRNA #rarediseases #raredisease #StopCodonDisease #geneticmedicines
-
-
As we work together to transform medicine, we never forget the power of teamwork, trust, and collaboration. This November, we dedicated an entire month to gratitude—celebrating our incredible team with meaningful moments of appreciation. From Thankful Thursdays featuring a potluck lunch to Thank You cards where we share personal notes of gratitude, we honored what makes Alltrna so special: our united spirit and relentless commitment to patients. Gratitude isn’t just for one month—it’s a value we carry every day. #GratitudeMonth #TeamAlltrna #WeAreAlltrna #Gratitude